Autophagy activation is involved in 3,4-methylenedioxymethamphetamine ('ecstasy')--induced neurotoxicity in cultured cortical neurons.
PLoS One December 31, 2014 Peer reviewed DOI: 10.1371/journal.pone.0116565 via PubMed Central
Summary
Autophagy activation plays a role in the neurotoxicity caused by 3,4-methylenedioxymethamphetamine, commonly known as 'ecstasy', in cultured cortical neurons. This suggests that autophagy may be a significant factor in the harmful effects of this substance on brain cells.
Study at a glance
| Population | cultured cortical neurons |
|---|---|
| Key finding | Autophagy activation is involved in ecstasy-induced neurotoxicity. |
Abstract
Autophagy activation is involved in 3,4-methylenedioxymethamphetamine ('ecstasy')--induced neurotoxicity in cultured cortical neurons.