An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'.
Warunya Arunotayanun, Jeffrey W Dalley, Xi-ping Huang, Vincent Setola, Ric Treble, Leslie Iversen, Bryan L Roth, Simon Gibbons
Bioorganic & medicinal chemistry letters June 1, 2013 Peer reviewed DOI: 10.1016/j.bmcl.2013.03.066 via PubMed
Summary
Alpha-methyl-tryptamine and 5-methoxy-N,N-diallyl-tryptamine are two tryptamine-derived novel psychoactive drugs that can cause serious effects like psychosis and hallucinations. These substances bind to various serotonin receptor subtypes, which may lead to injury or death. The study provides insights into their structural characteristics and how they interact with these receptors.
Study at a glance
| Key finding | The study reports on the structure and receptor binding profiles of two widely marketed tryptamine-derived NPDs. |
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Abstract
Novel Psychoactive Drugs (NPD) can be sold without restriction and are often synthetic analogues of controlled drugs. The tryptamines are an important class of NPD as they bind to the various serotonin (5-HT) receptor subtypes and cause psychosis and hallucinations that can lead to injury or death through misadventure. Here we report on the structure elucidation and receptor binding profiles of two widely marketed tryptamine-derived NPDs, namely alpha-methyl-tryptamine and 5-methoxy-N,N-diallyl-tryptamine.