Data from Is It Time to Advance the Chemoprevention of Environmental Carcinogenesis with Microdosing Trials?
Summary
Microdosing with environmental carcinogens may help speed up the evaluation and optimization of chemopreventive interventions. The discussion includes the necessity of chemoprevention for environmental carcinogenesis, the design of microdosing trials, required technologies, and ethical considerations. Insights from previous microdosing studies are also reflected upon.
Abstract
AbstractThis perspective on Jubert et al. (beginning on page [1015] in this issue of the journal) discusses the use of microdosing with environmental carcinogens to accelerate the evaluation and optimization of chemopreventive interventions. The need for chemoprevention of environmental carcinogenesis is considered, as are the structure of microdosing, or phase 0, trials, technologies required to conduct microdose studies in this context, and ethical concerns. We also reflect on what microdosing studies have taught us to date.