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Psychedelic therapy for body dysmorphic disorder

Shevaugn Johnson, Chris Letheby

Journal of Psychedelic Studies June 23, 2022 Peer reviewed DOI: 10.1556/2054.2022.00200 via OpenAlex

Summary

Psychedelic-assisted psychotherapy may be a promising treatment for body dysmorphic disorder (BDD), which involves intense preoccupations with appearance. Current treatments are often ineffective, leading to high rates of non-response and relapse. Preliminary evidence indicates that psychedelics could be safe and potentially effective for conditions similar to BDD. Therefore, a phase 2a study is recommended to evaluate the safety and feasibility of this approach in treating BDD.

Study at a glance

Design opinion piece
Key finding Investigating psychedelic-assisted psychotherapy for BDD could offer a new treatment avenue due to high rates of non-response and relapse with existing therapies.

Abstract

Abstract In this opinion piece we propose the investigation of psychedelic-assisted psychotherapy for the treatment of body dysmorphic disorder (BDD). BDD is a psychiatric disorder characterised by appearance-based preoccupations and accompanying compulsions. While safe and effective treatments for BDD exist, non-response and relapse rates remain high. Therefore, there is a need to investigate promising new treatment options for this highly debilitating condition. Preliminary evidence suggests safety, feasibility, and potential efficacy of psychedelic treatments in disorders that share similar psychopathological mechanisms with BDD. Drawing on this evidence, as well as on relevant qualitative reports and theoretical proposals, we argue that it would be worthwhile to conduct a phase 2a study aimed at assessing the safety and feasibility of psychedelic-assisted psychotherapy in BDD. We also offer some suggestions for how future research ought to proceed.

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