Big Five personality and the psychedelic experience: An initial report
Petri J. Kajonius, David Sjöström, Emma Claesdotter-knutsson
Journal of Psychedelic Studies November 24, 2025 Peer reviewed DOI: 10.1556/2054.2025.00414
Summary
Many users of psychedelics report a positive and lasting impact on their quality of life. In a study of 400 participants, those with higher openness in personality experienced more mystical and positive effects, while those with higher neuroticism reported more challenges and negative effects. Most participants viewed their psychedelic experiences as among the most meaningful in their lives. The study highlights the importance of considering individual personality differences in future research.
Study at a glance
| Sample size | 400 |
|---|---|
| Population | users of psychedelics |
| Key finding | Higher openness in personality is associated with enhanced mystical and positive experiences from psychedelics, whereas higher neuroticism is linked to increased challenges and negative reports. |
Abstract
Abstract A surge in societal and scientific discussion surrounds psychedelic research. One surprising fact keeps standing out: Many users report the psychedelic experience as a positive and lasting impact on their quality of life. The present study aimed to explore the quality and consequences of the most impacting psychedelic experience, with the user's Big Five personality in focus. This experienced sample ( N = 400) rated how challenging and mystical the experience was and the extent of positive and negative lasting life effects, together with the Big Five (IPIP-NEO-30). Interestingly, the results showed that most ranked it as among the most meaningful experiences in life, and that personality trait openness related to enhanced mystical and positive experiences, while neuroticism related to increased challenging and negative reports. We discuss limitations like the self-selected sample and the use of brief instruments. We conclude and recommend that individual differences in personality deserve continued consideration and should be measured and controlled for in future studies.