Exploring the importance of bodyset for the psychedelic experience and beyond
Malin Vedøy Uthaug, Giancarlo Allocca, Martha Havenith, Attila Szabo, Fernando Rosas, Johannes G. Ramaekers
Journal of Psychedelic Studies September 8, 2025 Peer reviewed DOI: 10.1556/2054.2025.00418
Summary
The paper introduces the concept of 'bodyset', which refers to the physical state of the body and brain, as an important factor in preparing for psychedelic experiences and therapy. It highlights that while mindset and setting are well recognized, the role of the body has been underexplored. The authors call for more comprehensive multidisciplinary research to understand how bodyset influences therapeutic outcomes in mental health disorders.
Study at a glance
| Key finding | Considering the body's physical state, or bodyset, alongside psychological and environmental factors may enhance understanding of psychedelic effects and therapeutic potential. |
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Abstract
AbstractBackgroundResearch has shown that psychedelics may have therapeutic potential in treating mental disorders like depression and anxiety. However, the mechanisms and actions underlying their effects are still not fully understood. Similarly, while the significance of mindset and setting in shaping psychedelic experiences and therapeutic outcomes is well established, information about the influence of the body is comparatively scarce.AimThis paper introduces the concept of bodyset, defined as the state of the body, including both the body and brain. We suggest it as a vital element in preparing for psychedelic experiences and beyond, broadening the traditional ‘set and setting’ framework.MethodsThrough an extensive literature review, we demonstrate the likely importance of the body in wellbeing, peak performance and peak experiences.ResultsComprehensive multidisciplinary research, particularly focusing on various biomarkers, is needed to elucidate the potential role of bodyset in the psychedelic experience and therapy outcomes, and to guide future treatment approaches for mental health disorders.ConclusionOur exploration of the bodyset concept emphasizes the importance of considering not only psychological and environmental factors (mindset & setting), but also the physical state of the body in preparation for psychedelic experiences and psychedelic therapy. This holistic perspective may enhance our comprehension of their effects, therapeutic potential and inform the application of other treatment modalities, such as breathwork, in mental health care.