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Historians on Drugs: Toward an Empirical Historiography of Global Psychedelic Cultures

Joseph Christian Greer

South Atlantic Quarterly April 1, 2025 Peer reviewed DOI: 10.1215/00382876-11626593 via OpenAlex

Summary

The article discusses two competing approaches in the study of psychedelics: 'pharmacological Calvinism,' which views users as degenerate, and the entheogenic school, which overemphasizes their cultural significance. Both perspectives hinder serious research. An empirical approach is suggested as a more balanced alternative, focusing on detailed analysis of primary sources and recognizing the diverse meanings of psychedelics in human history without claiming they are the sole key to cultural traditions.

Study at a glance

Key finding The empirical approach is proposed as a corrective to the biases of both dominant schools of thought regarding psychedelics.

Abstract

Scholarship on the global history of psychedelics is divided into two rival approaches. This article analyzes these approaches, emphasizing the way in which ideological biases on both sides have stymied serious research on the use of psychedelic substances across space and time, before introducing the empirical approach as an alternative. The most prevalent view, “pharmacological Calvinism,” essentializes mind-altering drugs and their users as degenerate or antisocial. This reductive approach has defined the intellectual mainstream across academic disciplines to the present. In contrast to pharmacological Calvinism, the entheogenic school offers a maximalist interpretation of psychedelics’ impact on human culture and cognition, presenting consciousness-expanding drugs as the “secret key” behind the world's religious traditions, mythology, and folklore. This article proposes that the empirical approach offers a corrective to the overstatements of both schools, as it is defined by comparatively granular research that draws from a deep understanding of primary sources placed in conversation with the intellectual apparatuses of the secondary literature. Distinctly uninterested in unveiling psychedelics as the “key” to any tradition, this approach interprets the multiplicity of meanings and values associated with powerful psychotropics, alongside other modes of ecstasy and transpersonal relationality, as an integral dimension of the human story.

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