Lysergic Acid Diethylamide: Review and Collaborative Study
Journal of AOAC INTERNATIONAL November 1, 1968 Peer reviewed DOI: 10.1093/jaoac/51.6.1318
Summary
A collaborative study involving 11 collaborators evaluated a method for identifying and determining lysergic acid diethylamide (LSD) using three samples. The method showed a recovery rate of 98.0% when using the Sandoz LSD-25 reference standard and 96.5% with the Ergonovine Maleate USP Reference Standard. This presumptive test is deemed valuable for rapid preliminary examination and is recommended for official adoption.
Study at a glance
| Sample size | 11 |
|---|---|
| Population | collaborators working on LSD identification methods |
| Key finding | The assay method for LSD identification achieved recovery rates of 98.0% and 96.5%, supporting its recommendation for official adoption. |
Abstract
Abstract A method for identification and determination of lysergic acid diethylamide (LSD) was studied collaboratively by 11 collaborators on three samples prepared by the Associate Referee. The presumptive test is a valuable tool for rapid preliminary examination. Racemization of the LSD adds further to its identification by paper chromatography. Assay recovery, based on Sandoz LSD-25 reference standard, was 98.0%. Recovery by the same assay, but based on Ergonovine Maleate USP Reference Standard, was 96.5%. The method is recommended for adoption as official, first action.