Treatment of Chronic Fatigue Syndrome (CFS) in Post-SARS-CoV-2 Infection through combined outpatient Neuromodulation Therapy with Repetitive Transcranial Magnetic Stimulation (rTMS) and Ketamine IV Therapy - A Case Series
Chiara Rolle, Mario H W Scheib, Anja Frank, Isabella Russ
preprint DOI: 10.31219/osf.io/qzgc9 1 citation
Summary
Four patients with post-COVID syndrome and chronic fatigue syndrome were treated with a combination of low-frequency repetitive transcranial magnetic stimulation and ketamine intravenous infusion over two to three weeks. Three patients experienced significant improvement. The authors indicate further research is needed.
Study at a glance
| Design | case series |
|---|---|
| Sample size | 4 |
| Population | patients with post-COVID syndrome and chronic fatigue syndrome |
| Key finding | Three of four patients with post-COVID syndrome and chronic fatigue syndrome experienced significant improvement after treatment with low-frequency rTMS and ketamine IV infusion. |
Abstract
The most reported symptom of post-COVID syndrome is pronounced fatigue (Malik et al., 2021; Venkatesan, 2021). In this case series, we present the treatment of four patients suffering from Post-COVID syndrome after more than 3 months since infection, presented diagnostically within the framework of chronic fatigue syndrome (CFS). They were treated with a combination of Low-frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) and ketamine intravenous (IV) infusion therapy for a period of 2 to 3 weeks. Three patients experienced significant improvement. Given the promising results further research is indicated.