Psychedelics: preclinical insights provide directions for future research
Ryan H. Gumpper, Bryan L. Roth
Neuropsychopharmacology January 1, 2024 DOI: 10.1038/s41386-023-01567-7 via Springer Nature
Summary
Psychedelics show promise as treatments for neuropsychiatric disorders, though their clinical potential is not fully understood. This review explores current knowledge of their basic biology, pharmacology, and structural biology, highlighting both established facts and unanswered questions as these compounds gain popularity in therapeutic and recreational settings.
Study at a glance
| Characteristics | Review Peer reviewed |
|---|---|
| Key finding | The review examines current understanding of psychedelics' biology, pharmacology, and structural biology, identifying knowns and unknowns in the field. |
Abstract
Recently, psychedelics have emerged as promising therapeutics for numerous neuropsychiatric disorders. While their potential in the clinic has yet to be fully elucidated, understanding their molecular and biological mechanisms is imperative as these compounds are becoming widely used both in therapeutic and recreational contexts. This review examines the current understanding of basic biology, pharmacology, and structural biology in an attempt to reveal both the knowns and unknowns within the field.