Synthesis, absolute configuration and in vitro cytotoxicity of deschloroketamine enantiomers: rediscovered and abused dissociative anaesthetic
Bronislav Jurásek, František Králík, Silvie Rimpelová, Jan Čejka, Vladimı́r Setnička, Tomáš Ruml, Martin Kuchař, Michal Kohout
New Journal of Chemistry January 1, 2018 DOI: 10.1039/c8nj03107j via OpenAlex
Summary
The dissociative drug deschloroketamine was synthesized, and the absolute configuration of its enantiomers was determined. The in vitro cytotoxicity of each enantiomer was tested across nine different cell lines, providing data on their relative toxicities.
Study at a glance
| Characteristics | In vitro study Peer reviewed |
|---|---|
| Population | Nine different cell lines |
| Keywords | Dissociative Enantiomer Absolute configuration Cytotoxicity In vitro |
| Citations | 15 |
| Key finding | The absolute configuration of deschloroketamine enantiomers was elucidated, and their in vitro cytotoxicity was determined across nine cell lines. |
Abstract
Deschloroketamine has been synthesized, the absolute configuration of enantiomers elucidated and the in vitro cytotoxicity of the enantiomers determined using nine different cell lines.