The central role of the Thalamus in psychosis, lessons from neurodegenerative diseases and psychedelics.
Transl Psychiatry December 13, 2023 DOI: 10.1038/s41398-023-02691-0
Summary
The brain's Thalamus, a vital sensory relay, appears central to how psychosis develops. It proposes that when this region, which filters sensory information, malfunctions, it contributes directly to psychotic symptoms. Insights from neurodegenerative diseases and the effects of psychedelics reveal consistent disruptions in thalamic function. This impairment leads to the brain misinterpreting reality. Pinpointing the Thalamus's role offers promising new avenues for developing effective therapies.
Abstract
The central role of the Thalamus in psychosis, lessons from neurodegenerative diseases and psychedelics.