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Effectiveness of an online mindfulness-based stress-reduction intervention to reduce anxiety in breast cancer survivors: a randomized-controlled trial.

Ana Ferrigno Guajardo, Misael Salazar-Alejo, Fernanda Mesa-Chavez, Javier Gutierrez-Ornelas, Alejandra Platas, Haydee Verduzco-Aguirre, Cynthia Villarreal-Garza

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer June 24, 2025 DOI: 10.1007/s00520-025-09681-6

Summary

A remarkable finding shows online mindfulness can dramatically reduce anxiety for breast cancer survivors. An 8-week online program significantly lowered anxiety, depression, fatigue, and insomnia in participants. This accessible mindfulness intervention improved psychological well-being during survivorship, offering a positive path to better health.

Abstract

This study evaluated the efficacy of an online mindfulness-based stress reduction (MBSR) intervention in reducing anxiety among breast cancer (BC) survivors, leveraging the potential advantages of digital delivery to enhance psychosocial care for this population. In this randomized controlled trial, 68 BC survivors with elevated anxiety levels were assigned to either an 8-week online MBSR intervention (n = 33) or a waitlist control group (n = 35). Anxiety (GAD-7), depression (PHQ-9), fatigue (FACIT-F), insomnia (ISI), cancer-related worry (CWS), vasomotor symptoms (MENQOL), and mindful awareness (MAAS) were assessed at baseline, post-intervention, and at 5- and 8-months follow-up. Compared to the control group, MBSR participants showed significant reductions in anxiety (mean difference -4.13 points, 95CI -6.79 to -1.46, p = 0.003), depression (mean score difference -6.03, p 0.05). MBSR participants also demonstrated increased mindful awareness (mean difference + 1.00, p = 0.004) that persisted through follow-up. The proportion of participants with clinically significant anxiety decreased from 96% pre-intervention to 38% at 8-months follow-up in the MBSR group, compared to relatively stable rates (88% to 87%) in the control group. Online MBSR is a potentially effective intervention for reducing anxiety and improving psychological well-being in BC survivors. This accessible format may help overcome barriers to psychosocial care for cancer survivors. NCT05837169.

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