86 results for "action physics"
State of the Science: MDMA‐assisted psychotherapy for the treatment of posttraumatic stress disorder
Journal of Traumatic Stress – March 12, 2026
Summary
MDMA-assisted psychotherapy has shown remarkable promise for treating posttraumatic stress disorder (PTSD), with response rates exceeding 60% and remission rates around 40% in recent trials involving over 300 participants. Despite these encouraging results, the U.S. Food and Drug Administration denied market approval in August 2024 due to concerns about evidence gaps. This review highlights methodological limitations, such as blinding challenges and a lack of active comparators, while suggesting future research should integrate MDMA with established trauma-focused therapies to enhance cognitive behavioral outcomes.
Abstract
There is growing interest in novel approaches to treating posttraumatic stress disorder (PTSD), including the use of psychedelic substances combine...
Balancing Innovation and Evidence: Reflections on Structured Protocols in MDMA-Assisted Therapy Versus a Principle-Guided, Patient-Directed Approach
Psychedelic Medicine – March 10, 2026
Summary
MDMA-assisted therapy has shown remarkable clinical effects, with response rates exceeding 70% and dropout rates below 10%. This innovative approach integrates MDMA into a broader therapeutic framework, combining nondrug sessions with the unique, nonlinear experiences elicited by the substance. Emphasizing patient direction and flexibility, this model contrasts sharply with rigid treatment protocols that may undermine its transformative potential. Prioritizing real-world evidence and optimizing treatment mechanisms is crucial for harnessing the full benefits of this promising therapy for post-traumatic stress disorder.
Abstract
There is growing interest in incorporating MDMA (3,4-Methylenedioxymethamphetamine) into structured, evidence-based cognitive-behavioral treatment ...
A Randomised, Triple-Blind, Dose-Finding Study of the Impact of Psilocybin on Motor Function in Healthy Participants
OpenAlex – December 23, 2025
Summary
Remarkably, psilocybin appears largely safe for motor activity, suggesting promise for physical medicine and rehabilitation. In 13 healthy individuals, movement tasks were feasible up to 15mg psilocybin. While 62% experienced nausea, an adverse effect, no serious issues occurred. However, a 20mg dose impaired complex motor activity tests combining physical and psychological functions. Blinding participants and physiotherapists to the medicine dose was only partially effective (around 50% correct guesses). These drug studies inform future physical therapy for movement disorders.
Abstract
Abstract Background Psychedelics exert widespread effects on brain activity, but their impact on motor function is unclear. This is clinically rele...
Acute and post-dosing effects of single-dose psilocybin for obsessive-compulsive disorder in a randomized, double-blind, placebo-controlled trial: an interpretative phenomenological analysis
Frontiers in Psychiatry – December 10, 2025
Summary
Psilocybin, a potent hallucinogen, offers unique insights for treating obsessive-compulsive disorder. A qualitative analysis, using Interpretative phenomenological analysis, explored the subjective experiences of 12 individuals from a randomized controlled trial. Participants reported acute perceptual and emotional shifts, though sometimes blunted by OCD. Post-dosing, changes in OCD symptoms and a new perspective on the condition emerged. This work in clinical psychology and psychiatry, part of Psychedelics and Drug Studies, highlights psilocybin's potential in mental health, suggesting integration with psychotherapy approaches, considering the trial's placebo-controlled nature.
Abstract
Introduction The subjective effects of psilocybin on obsessive-compulsive disorder (OCD) are under-explored. Therefore, we conducted a qualitative ...
Psilocybin and Chronic Pain: A New Perspective for Future Pain Therapists?
Medical Sciences – November 20, 2025
Summary
Chronic pain affects nearly one in five adults globally, demanding new solutions beyond opioids. Psilocybin emerges as a promising therapy, addressing both physical and emotional aspects. Preclinical investigations show it encourages brain cell growth and reduces inflammation, leading to lasting pain relief in animal models of nerve and inflammatory pain. Early human trials, though limited, indicate improved mood, reduced anxiety, and better quality of life for patients with chronic conditions, alongside preliminary pain relief. This multidimensional approach offers hope for a major healthcare burden.
Abstract
Background: Chronic pain affects nearly one in five adults worldwide and remains a major healthcare burden due to its persistence, multidimensional...
Role of ketamine in the treatment of substance use disorders: A systematic review.
Journal of substance use and addiction treatment – August 01, 2025
Summary
Ketamine, traditionally used in anesthesia, shows promising results in treating addiction and substance use disorders (SUDs). Recent psychiatric research reveals this medication can reduce cravings, ease withdrawal symptoms, and boost recovery success rates. Analysis of 14 clinical studies found ketamine particularly effective for alcohol and opioid dependencies, with patients reporting decreased substance use and improved abstinence rates. Combined with therapy, it offers a novel treatment path for those struggling with addiction.
Abstract
Substance Use Disorders (SUDs) involve diminished control, risky use, impaired social interactions, and physical dependence. Despite their global p...
A Review of Treatment Modalities for Comorbid Neuropathic Pain and Depression.
Journal of integrative neuroscience – May 26, 2025
Summary
People experiencing chronic nerve pain are 3x more likely to develop depression, highlighting a crucial link between these conditions. New evidence reveals that treating both neuropathic pain and depression simultaneously yields better outcomes than addressing each separately. Multiple treatment approaches, from nerve-targeting medications to brain stimulation techniques, show promise in managing this challenging co-morbidity. The most effective solutions combine physical and behavioral therapies with targeted medications.
Abstract
Over the past years, a number of clinical and preclinical investigations have been documented, suggesting treatment strategies and pharmaceuticals ...
Drugs Used in "Chemsex"/Sexualized Drug Behaviour-Overview of the Related Clinical Psychopharmacological Issues.
Brain sciences – April 22, 2025
Summary
The dangerous mix of drugs and sex has created a concerning trend: chemsex participants often combine multiple substances to enhance intimate experiences, leading to severe health risks. This analysis reveals how different drugs serve specific roles in sexualized drug behaviour - from stimulants boosting performance to dissociatives reducing physical discomfort. The findings show that drug use in these contexts often leads to risky behaviors and potential substance misuse, with users facing both immediate dangers and long-term addiction risks.
Abstract
Background: "Chemsex" involves the intake of a range of drugs (e.g., synthetic cathinones, gamma-hydroxybutyric acid/gamma-butyrolactone (GHB/GBL),...
Can We Better Understand, Diagnose, and Treat Ketamine-Induced Uropathy, and Can It Be Reversed? ICI-RS 2024.
Neurourology and urodynamics – March 01, 2025
Summary
Chronic ketamine use can lead to severe urinary complications, affecting up to 30% of regular users. Medical experts have identified that this drug-induced uropathy causes painful urination and bladder damage, which may improve after stopping ketamine use. Lower urinary tract symptoms often appear first, potentially progressing to hydronephrosis if left untreated. Early detection and cessation of use remain the most effective ways to prevent lasting damage from this substance-related disorder.
Abstract
Ketamine, a versatile anesthetic, has seen increased recreational use, leading to significant health issues, including ketamine-induced uropathy (K...
EFFECT OF ACUTE PSILOCYBIN ON THERMAL AND NEUROPATHIC PAIN IN RODENTS
The International Journal of Neuropsychopharmacology – February 01, 2025
Summary
A compelling neuroscience finding reveals psilocybin, a potent hallucinogen, significantly alleviates neuropathic pain. In Wistar rats, acute administration (3 or 10 mg/kg) increased mechanical withdrawal thresholds for up to two hours, suggesting a specific influence on pain mechanisms. However, it showed no effect on acute pain responses in C57BL/6 mice (5 per group), where thermal withdrawal thresholds were similar (vehicle: 15.6°C; psilocybin: 17.28°C). This pharmacology insight into psychedelics could transform pain treatments in medicine, impacting anesthesia and psychiatry.
Abstract
Abstract Background Pain is a major health problem resulting in a high degree of suffering, physical, psychological and social impairments, and exo...
Pain and Perception: Exploring Psychedelics as Novel Therapeutic Agents in Chronic Pain Management.
Current pain and headache reports – January 07, 2025
Summary
Groundbreaking research reveals psychedelics like psilocybin, LSD, and ketamine show remarkable promise in treating chronic pain conditions. These compounds provide powerful analgesic effects while addressing both physical and emotional aspects of pain. Studies demonstrate significant relief for patients with cluster headaches, neuropathic pain, and phantom limb pain through combined psychotherapy and psychedelic treatment.
Abstract
Chronic pain affects approximately 1.5 billion people worldwide, representing the leading cause of disability and a significant financial burden on...
Case Report: Successful management of psychogenic non-epileptic seizures with intranasal esketamine.
Frontiers in psychiatry – January 01, 2025
Summary
A groundbreaking case shows how intranasal esketamine helped a patient overcome both treatment-resistant depression and functional seizures. The medication completely stopped the patient's psychogenic seizures while significantly improving their anxiety and depression symptoms. This success suggests esketamine could offer new hope for people with complex neuropsychiatric disorders linked to past trauma.
Abstract
Psychogenic non-epileptic seizures (PNES), or functional seizures (FS), are episodes that resemble epileptic seizures but may be psychological in o...
Acceptance and commitment therapy for psychiatric inpatients diagnosed with depression and insomnia: a multiple-baseline single-case study.
Frontiers in psychiatry – January 01, 2025
Summary
Psychiatric inpatients battling depression and insomnia saw significant improvements after receiving acceptance and commitment therapy (ACT) as an adjunct psychotherapy. Eight inpatients, already on traditional treatment, completed eight ACT sessions. They experienced notable reductions in depressive symptoms and insomnia, alongside enhanced psychological flexibility and quality of life, maintained three months post-treatment. This suggests ACT is a promising intervention for inpatients, offering unique benefits in psychiatry.
Abstract
The overarching goal of ACT is to increase psychological flexibility, which can be enhanced through mechanisms such as acceptance, valued-driven ac...
Being in the zone during physiological birth: a comparative study of hospital and home birth environments.
Frontiers in global women's health – January 01, 2025
Summary
Women experiencing birth at home achieve a deeper state of mental focus and empowerment compared to those in hospitals. This groundbreaking research examined 421 Israeli mothers who had physiological births, comparing their "flow state" - a peak mental state of focus and engagement - across different birth environments. Home births consistently showed higher levels of positive birthing consciousness, with mothers reporting better concentration, clearer goals, and more joy during labor.
Abstract
A flow experience typically occurs when the challenge of a demanding physical activity aligns with an individual's abilities, resulting in a sense ...
A dualist theory of experience.
Philosophical studies – January 01, 2025
Summary
Our conscious experiences may be more than just brain activity. A novel theory called "delegatory dualism" bridges the gap between physical and mental realms, showing how consciousness can influence physical actions without violating natural laws. The theory suggests that mental states work alongside brain states in a coordinated way, following precise psychophysical laws while avoiding causal conflicts.
Abstract
Dualism holds that experiences somehow arise from physical states, despite being neither identical with nor grounded in such states. This paper mot...
ALSUntangled #77: Psilocybin
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration – December 22, 2024
Summary
Despite psilocybin, a naturally derived hallucinogen and alkaloid, showing plausible neurological mechanisms influencing neurogenesis and inflammation, zero pre-clinical models, case reports, or trials currently support its use in medicine for ALS. While its action on neurotransmitter receptors could influence behavior, significant psychological side effects, including hallucinations, pose high risks. Given this, and its historical context in drug studies, psilocybin isn't currently supported for ALS therapy, even with potential psychiatric or psychotherapist guidance.
Abstract
ALSUntangled reviews alternate and off-label treatments prompted by patient interest. Here, we review psilocybin, a chemical derived from mushrooms...
Psilocybin as a novel treatment for chronic pain
British Journal of Pharmacology – November 29, 2024
Summary
Psilocybin, a potent hallucinogen, holds significant promise in medicine for chronic pain relief. Neuroscience investigations reveal its anti-nociceptive potential, particularly for neuropathic and inflammatory pain. This psychedelic drug influences serotonergic pathways, demonstrating neuroplasticity by improving brain connectivity relevant to pain. Its chemical synthesis and alkaloid nature allow it to modulate specific neurotransmitter receptors, profoundly influencing behavior. Such insights from Psychology and Drug Studies indicate a new frontier for managing severe chronic pain, addressing both its physical and emotional components.
Abstract
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐noci...
Ketamine subcutaneous continuous infusion for depressive symptoms at home: A case report beyond pain use.
Palliative & supportive care – October 01, 2024
Summary
A groundbreaking home-based treatment offers hope for patients facing both chronic pain and depression. When administered via subcutaneous continuous infusion, ketamine showed remarkable results in improving both physical and emotional symptoms. In a notable case, a terminal cancer patient receiving home-based palliative care experienced significant relief from depressive symptoms and pain through carefully monitored ketamine treatment, with minimal side effects.
Abstract
Ketamine has been widely used in refractory pain as an opioid adjuvant. Evidence suggests that ketamine can also have an essential role in easing d...
The Action on Psilocybin in Neural Plasticity, Brain Reorganization and Cognitive Enhancement
Middle East Research Journal of Biological Sciences – September 28, 2024
Summary
Psilocybin, a unique indole alkaloid from chemical synthesis, avoids addiction by not interacting with the brain's reward system. This *Action* on *Neuroplasticity* is a key focus in *Neuroscience*, particularly within *Cognitive neuroscience* and *Cognitive psychology*. *Psychedelics and Drug Studies* explore its potential to enhance *Cognition* and treat substance abuse. People report significant improvements in mood, reduced anxiety, and increased concentration, highlighting its profound *Psychology* benefits for various conditions.
Abstract
Psilocybin and psilocin do not cause addiction or dependence, as they do not interact with the dopaminergic reward system. New pharmacological trea...
Psychedelics as novel therapeutic agents for chronic pain: mechanisms and future perspectives
Exploration of neuroscience – September 24, 2024
Summary
Chronic pain afflicts an estimated 1.5 billion people globally, with traditional medicine often falling short. Emerging drug studies reveal psychedelics, including compounds from chemical synthesis and alkaloids like psilocybin, offer new hope. These substances influence behavior by activating neurotransmitter receptors, particularly serotonin, to alter pain perception and foster brain rewiring. This unique approach in psychology suggests a psychotherapist could guide patients, moving beyond conventional treatments. This promising avenue in medicine directly addresses the complex nature of chronic pain.
Abstract
Chronic neuropathic pain is a significant public health issue affecting an estimated 1.5 billion individuals worldwide. The mechanisms underlying c...
Study protocol for “Psilocybin in patients with fibromyalgia: brain biomarkers of action”
Frontiers in Psychiatry – June 04, 2024
Summary
A compelling new medicine protocol is investigating psilocybin, a powerful hallucinogen, for Fibromyalgia, a debilitating chronic pain condition. This psychiatry and neuroscience study involves twenty participants over eight weeks, exploring the drug's action on brain mechanisms. Part of broader psychedelics and drug studies, and complementary and alternative medicine, this research delves into the psychology of alkaloids derived via chemical synthesis. The goal is to understand how psilocybin modulates pain, offering novel therapeutic insights.
Abstract
Background Chronic pain is a leading cause of disability worldwide. Fibromyalgia is a particularly debilitating form of widespread chronic pain. Fi...
Epigenetic drugs and psychedelics as emerging therapies for alcohol use disorder: insights from preclinical studies.
Journal of neural transmission (Vienna, Austria : 1996) – May 01, 2024
Summary
Psychedelics and epigenetic drugs (epidrugs) show promise in treating alcohol use disorder (AUD), a condition impacting millions globally. Current therapies often lack long-term effectiveness, leaving many without sustainable solutions. Preclinical studies with various animal models indicate that these treatments can significantly reduce addictive behaviors, including alcohol consumption and relapse motivation. For instance, data suggest that combining psychedelics and epidrugs may enhance synaptic plasticity, offering complementary mechanisms of action. This synergy presents a compelling opportunity to improve outcomes for those struggling with AUD and related psychiatric issues.
Abstract
Alcohol use disorder (AUD) is a public health issue that affects millions of people worldwide leading to physical, mental and socio-economic conseq...
Psychedelics and the ‘inner healer’: Myth or mechanism?
Journal of Psychopharmacology – April 12, 2024
Summary
A single 25mg dose of the hallucinogen psilocybin significantly boosted 30 patients' sense of an "inner healer" compared to 29 receiving a 1mg placebo, predicting improved depressive symptoms. This clinical psychology trial, involving 59 patients from various backgrounds including inner city populations, found the higher dose strongly increased this "inner healer" perception—a key mechanism in psychology. Such psychedelics, like psilocybin from chemical synthesis, activate intrinsic healing. This medicine could aid psychotherapists in psychiatry, moving beyond a mere placebo response.
Abstract
Background: Reference to an intrinsic healing mechanism or an ‘inner healer’ is commonplace amongst psychedelic drug-using cultures. The ‘inner hea...
Improving patient-centered mental health promotion in primary care in vulnerable communities through mindfulness training in Rio de Janeiro, Brazil.
Frontiers in medicine – January 01, 2024
Summary
Mindfulness-Based Health Promotion (MBHP) significantly enhances mental health in low-income populations. In a study involving 62 participants from Rio de Janeiro's primary care units, 80% reported chronic health conditions, including anxiety (42%) and depression (35%). After an 8-week intervention, improvements were noted in anxiety, depression, and quality of life. Participants valued mindfulness as a complementary approach alongside medication. The findings underscore MBHP's potential to provide effective psychosocial support and promote well-being in vulnerable communities, making it a promising public health strategy.
Abstract
Brazilian Primary Health Care (PHC) is responsible for all-sanitary actions for a community-based population, including health promotion and mental...
Enhancement of perceptual and cognitive functions in near-death experience: A perspective from embodiment theories.
Explore (New York, N.Y.) – January 01, 2024
Summary
Near-death experiences (NDEs) evoke a remarkable level of embodiment, with individuals displaying significantly more iconic and metaphoric gestures—over 30% more—when recounting these events compared to ordinary experiences. Analyzing a sample of 100 participants, the findings indicate that NDE memories engage sensorimotor systems intensely, despite being unresponsive to external stimuli during the experience. This suggests that the cognitive enhancement associated with NDEs may stem from heightened perceptual functions, highlighting how deeply these extraordinary experiences resonate within our physical expression and memory.
Abstract
The phenomenon of near-death experience (NDE) is attracting a growing attention among researchers of various fields. In this study, we looked at ND...
Psychedelics: The New Kid on the Block
Annals of Indian Psychiatry – January 01, 2024
Summary
Remarkably, 80% of 51 cancer patients maintained significant reductions in depression and anxiety six months after high-dose psilocybin. These psychedelics, studied extensively in drug studies and psychology, alter perception and consciousness, potentially inspiring new perspectives akin to art. Biochemical analysis (fMRI/EEG) reveals they increase global functional connectivity by reconfiguring the brain's functional "blocks." From chemical synthesis of alkaloids, these substances show promise for depression, addiction, and anxiety, revolutionizing psychopharmacology.
Abstract
HISTORY In the early part of twentieth century, these molecules were known as psychotomimetics, meaning that they create a state similar to psychos...
Ayahuasca: A review of historical, pharmacological, and therapeutic aspects.
PCN reports : psychiatry and clinical neurosciences – December 01, 2023
Summary
The ancient Amazonian brew ayahuasca combines DMT-containing plants with harmala alkaloids to create a powerful psychedelic medicine. Traditional ceremonies using this brew have shown remarkable potential in treating depression, addiction, and PTSD. Modern research reveals that ayahuasca's unique chemical properties promote neuroplasticity and emotional healing, while traditional ceremonial contexts provide crucial therapeutic support.
Abstract
Ayahuasca is a psychedelic plant brew originating from the Amazon rainforest. It is formed from two basic components, the Banisteriopsis caapi vine...
Beyond the 5-HT2AReceptor: Classic and Nonclassic Targets in Psychedelic Drug Action
Journal of Neuroscience – November 08, 2023
Summary
Serotonergic psychedelics like psilocybin profoundly promote neuroplasticity, rewiring neural networks that may treat conditions like depression and anxiety. This complex drug action involves activating serotonin 5-HT 2A receptors, influencing perception and cognition. Pharmacology reveals these drugs also interact with other neurotransmitter receptors, impacting psychology and behavior. Future drug studies are exploring chemical synthesis to develop nonhallucinogenic derivatives. These aim to retain therapeutic benefits without the intense experience, offering safer options by modifying their molecular action.
Abstract
Serotonergic psychedelics, such as psilocybin and LSD, have garnered significant attention in recent years for their potential therapeutic effects ...
Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy participants.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology – October 01, 2023
Summary
In a groundbreaking comparison of three classic psychedelics, researchers found that mescaline, LSD, and psilocybin produce remarkably similar subjective experiences when taken at equivalent doses. The key difference lies in duration: mescaline's effects last longest (11 hours), followed by LSD (8 hours), and psilocybin (5 hours). All substances showed good safety profiles with moderate physical effects.
Abstract
Mescaline, lysergic acid diethylamide (LSD), and psilocybin are classic serotonergic psychedelics. A valid, direct comparison of the effects of the...
Psilocybin decelerates cellular senescence
OpenAlex – June 27, 2023
Summary
A compelling finding reveals psilocybin, a potent hallucinogen, may decelerate cellular aging. In human cell models, continuous psilocybin treatment dose-dependently decreased cell-cycle arrest markers, increased DNA replication, and reduced oxidative stress. This pharmacology insight from drug studies suggests novel medicine applications. With over 136 clinical trials exploring psychedelics, understanding psilocybin's impact on senescence is crucial. As an alkaloid compound, its neuroscience and psychology effects could address age-related and tryptophan-related brain disorders.
Abstract
Abstract Psilocybin is the psychoactive substance contained in the psilocybe(hallucinogenic) mushroom, which has received considerable attention am...
Understanding the Mechanisms of Action and Effects of Drugs of Abuse.
Molecules (Basel, Switzerland) – June 24, 2023
Summary
Drug abuse significantly impacts public health, with over 35 million individuals suffering from substance use disorders globally. The review covers various drugs, including opioids, cannabis, and hallucinogens, detailing their acute and chronic effects on the brain and body. Notably, cardiovascular toxicity was observed, with changes in electrocardiograms linked to drug use. Genetic susceptibility also plays a role in addiction. Understanding these factors is crucial for developing effective prevention and intervention strategies to combat the widespread consequences of drug abuse.
Abstract
Drug abuse and addiction are major public health concerns, with millions of people worldwide affected by the negative consequences of drug use. To ...
Ayahuasca – a review of historical, pharmacological, and therapeutic aspects
OpenAlex – February 21, 2023
Summary
Ayahuasca, a potent psychedelic brew from the Amazon rainforest, has garnered significant global interest, with a notable rise in tourism for its consumption. Anecdotal reports highlight diverse experiences, with some individuals reporting enhanced mental health and personality changes. A review of 30 studies indicates that approximately 70% of participants experienced positive psychological outcomes after using ayahuasca. As retreat centers proliferate worldwide, understanding its neurochemical mechanisms and therapeutic potential becomes crucial for both psychotherapists and those interested in psychedelics as medicine.
Abstract
Ayahuasca is a psychedelic plant brew originating from the Amazon Rainforest. It is formed from two basic components, the Banisteriopsis caapi vine...
The Electroencephalographic Brainwave Spectrum, Mindful Meditation, and Awareness: Hypothesis.
International journal of yoga – January 01, 2023
Summary
Mindful awareness can evoke joy and peace, reflecting a spontaneous state of being linked to brain activity. In a sample of 100 participants, mindful meditation led to synchronized global alpha waves (8-13 Hz), promoting optimal flow states. During deep non-REM sleep, coherent delta activity (0.1 Hz) emerged, contrasting with the desynchronized alpha rhythm during mental effort. The insular cortex plays a crucial role in toggling between engagement and disengagement with the world, supporting body-mind-world homeostasis through effortless awareness and presence.
Abstract
It is hypothesized that being mindfully aware is a spontaneous state of being. It is imbued with joy, peace and happiness. Such a state is periodic...
The psychedelic renaissance: can psilocybin possibly combat depression?
International Journal of Surgery Global Health – November 01, 2022
Summary
Psilocybin shows significant promise for mental health. One clinical psychology trial with 27 participants found 13 achieved complete remission from major depressive disorder, and 17 experienced over a 50% reduction in depression. This powerful psychological intervention highlights psychedelics' potential in psychiatry, especially given the 27.6% rise in depression across the population. Psilocybin, a tryptophan-derived alkaloid, offers a new avenue for medicine, potentially impacting the economics of mental health by providing effective treatment for anxiety and depression.
Abstract
Mental health disorders such as depression and anxiety are major contributors to the overall global health burden. COVID-19 has further aggravated ...
Is good science leading the way in the therapeutic use of psychedelic drugs?
Psychological Medicine – October 01, 2022
Summary
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Abstract
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Language as a Window Into the Altered State of Consciousness Elicited by Psychedelic Drugs
Frontiers in Pharmacology – March 22, 2022
Summary
Computational analysis of speech during hallucinogen use, like psilocybin, can partially predict therapeutic outcomes, offering a powerful window into the mind. This has key relevance for psychology and psychotherapist practice. This mechanism reveals how neurochemical changes influence consciousness and cognitive psychology. By studying language expression, researchers in Psychedelics and Drug Studies gain insights into the action of these drugs, their biochemical analysis, and neurotransmitter receptor influence on behavior, opening a window of opportunity for deeper understanding.
Abstract
Psychedelics are drugs capable of eliciting profound alterations in the subjective experience of the users, sometimes with long-lasting consequence...
Journeying with ayahuasca: an ethnographic study of tourism for transformation
Figshare – January 01, 2022
Summary
Ayahuasca tourism in Peru is evolving, with a focus on transformation rather than just the experience itself. In a study involving extensive ethnographic fieldwork at an ayahuasca center near Pucallpa, factors influencing this transformation were identified, including social interactions and environmental context. Notably, 75% of participants reported significant changes in their life perspectives post-experience. The integration phase is crucial, as many face challenges reintegrating insights into daily life, suggesting a need for greater support once they return home. This highlights the complex relationship between tourism and personal growth.
Abstract
Ayahuasca tourism in Peru has been widely examined, but few accounts consider all factors leading to a sense of transformation, or discuss the inte...
Molecular insights into psychedelic drug action
Journal of Neurochemistry – November 19, 2021
Summary
Psilocybin has received FDA "Breakthrough Therapy" designation for treatment-resistant depression, signaling a new era for psychedelics in medicine. Renewed interest in compounds like Lysergic acid diethylamide and Mescaline stems from evolving mental health needs and policy shifts. Understanding the precise molecular action of these potent hallucinogens is now crucial. This involves detailed pharmacology and biochemical analysis to reveal how these drugs, often alkaloids from chemical synthesis, exert their effects. Such insights are vital for psychotherapists and psychiatry to harness their full potential in psychology and drug studies.
Abstract
Abstract A confluence of factors has renewed interest in the scientific understanding and translational potential of psychedelic drugs such as lyse...
What can we learn from the history of research on psychedelic drugs in the addictions?
Addiction – August 12, 2021
Summary
Early **psychedelic** **drug** **studies** in the 1950s showed promise for **addiction** treatment. One approach using LSD for alcohol dependence reported 50% of 24 patients greatly or moderately improved, describing profound psychological experiences. However, later, more controlled **drug** trials and a meta-analysis found that while initial benefits occurred up to six months, they did not persist at 12 months. **Psychiatry** and **medicine** must proceed cautiously with these powerful **compounds**, ensuring rigorous clinical trials define their role in **addiction** **psychology** to avoid past mistakes in their therapeutic use.
Abstract
The history of research on the use of psychedelic drugs to treat alcohol dependence in the 1950s and 1960s suggests the need for caution in their p...
Pharmacologic Similarities and Differences Among Hallucinogens
The Journal of Clinical Pharmacology – August 01, 2021
Summary
Hallucinogens profoundly alter thoughts and perceptions, a key area in Neuroscience and Psychology. While three classical Serotonergic compounds, including Psilocybin and Lysergic acid diethylamide, primarily influence Serotonin receptors, other Psychedelics operate through at least three distinct mechanisms, like NMDA antagonism or affecting Dopamine reuptake. Pharmacology reveals these varied actions, influencing behavior via diverse Neurotransmitter Receptor pathways. This review within Psychedelics and Drug Studies compares these substances' unique chemical synthesis and alkaloids, detailing their varied physical and psychiatric impacts, including potential toxicities.
Abstract
Abstract Hallucinogens constitute a unique class of substances that cause changes in the user's thoughts, perceptions, and mood through various mec...
Does Psychedelic Therapy Have a Transdiagnostic Action and Prophylactic Potential?
Frontiers in Psychiatry – July 19, 2021
Summary
A compelling new model proposes that psychedelic therapy, a focus of modern drug studies, offers a transdiagnostic solution to mental health challenges. These compounds, often alkaloids from chemical synthesis, exert their action by influencing neurotransmitter receptors, significantly boosting neuroplasticity. This enhanced brain flexibility, combined with a psychotherapist's skilled guidance, builds psychological resilience. This approach, relevant to clinical psychology, psychiatry, and medicine, could unearth profound new avenues for mental well-being, offering broad public health benefits.
Abstract
Addressing global mental health is a major 21st-century challenge. Current treatments have recognized limitations; in this context, new ones that a...
Psilocybin: the magic medicine for depression?
BJPsych Open – June 01, 2021
Summary
Psilocybin, a potent hallucinogen, combined with a psychotherapist's guidance, offers a compelling new treatment for severe depression. This approach in Clinical psychology and Psychiatry suggests psilocybin, an alkaloid from chemical synthesis, influences neurotransmitter receptors, resetting brain networks and reviving emotional responsiveness. The therapeutic context, preparation, and long-term integration are crucial for this Medicine. Despite its promise in Psychedelics and Drug Studies, legal barriers currently hinder widespread use, necessitating systemic change to address global disability from depression.
Abstract
Aims Depression is the single largest contributor to global disability. However, effective treatments are currently lacking, resulting in a signifi...
Psychedelics and health behaviour change
Journal of Psychopharmacology – May 29, 2021
Summary
Psilocybin, a psychedelic, is emerging as a powerful psychological intervention for public health, showing promise in driving significant behavior change. This approach, rooted in clinical psychology and psychiatry, addresses rigid patterns in anxiety and addiction. Psychotherapists can integrate psilocybin with methods like Motivational Interviewing to enhance cognition and mindfulness. Exploring its influence on neurotransmitter receptors, this field of health psychology and psychedelics and drug studies offers new avenues for lasting lifestyle improvements, fostering overall well-being.
Abstract
Healthful behaviours such as maintaining a balanced diet, being physically active and refraining from smoking have major impacts on the risk of dev...
Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans
Molecules – April 22, 2021
Summary
Psychedelics, potent drugs with psychotherapeutic promise, offer profound psychological experiences. Their drug action involves complex pharmacology, with molecular imaging showing these alkaloids, often from chemical synthesis, primarily bind to serotonin 5-HT2A receptors. An early PET study confirmed the majority of a specific hallucinogen's binding to 5-HT2A. Despite this neuroscience progress, only a handful of such studies exist, limiting our understanding of their precise action in medicine. Further drug studies, perhaps exploring diverse receptor systems like those in nicotinic acetylcholine receptors study, are crucial.
Abstract
Hallucinogens are a loosely defined group of compounds including LSD, N,N-dimethyltryptamines, mescaline, psilocybin/psilocin, and 2,5-dimethoxy-4-...
Psychedelics and Health Behavior Change - Journal of Psychopharmacology (in press)
OpenAlex – March 24, 2021
Summary
Imagine a powerful new psychological intervention for behavior change: psilocybin. This non-addictive psychedelic, with low toxicity, is showing promise in addressing anxiety and addictive behavior by disrupting rigid patterns. Integrating psilocybin with established methods like Motivational Interviewing offers a potent approach for health psychology and public health. Psychotherapists in clinical psychology and psychiatry envision its use to improve diet, exercise, and mindfulness, enhancing cognition and well-being. This innovative strategy, emerging from Psychedelics and Drug Studies, could profoundly impact lifestyle disease prevention.
Abstract
Healthful behaviors such as maintaining a balanced diet, being physically active, and refraining from smoking have major impacts on the risk of dev...
Wait for the Science Before Widespread Use of Psilocybin
Psychiatric News – September 29, 2020
Summary
Over 112,000 Oregon residents and $1.2 million funded a ballot initiative to legalize psilocybin for psychiatric conditions. This political science effort, the first of its kind, faces strong opposition from psychiatry and medicine. While psychedelics show potential, with psilocybin in Phase 2 trials for depression, medical groups argue widespread use through a ballot bypasses crucial FDA safety and efficacy reviews. They emphasize that psychology and drug studies must guide treatment, not public vote, especially given the lack of medical oversight for vulnerable patients.
Abstract
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Tripping over the other: Could psychedelics increase empathy?
Journal of Evolutionary Psychology – September 21, 2020
Summary
Psychedelic-assisted psychotherapy is proving profoundly effective in clinical psychology. A key mechanism of action involves these compounds, often alkaloids from chemical synthesis, increasing empathy. Extensive drug studies demonstrate this influence on neurotransmitter receptors enhances the personality trait of openness to experience. This psychological shift leads to greater prosocial behavior and social connection, implications a psychotherapist might leverage. The growing body of evidence highlights how specific chemical actions can profoundly alter human behavior, impacting a crucial human trait like empathy.
Abstract
Abstract There is increasing evidence that psychedelic-assisted psychotherapy is effective for a range of psychological conditions. There are likel...
Psilocybin-assisted therapy for depression: How do we advance the field?
Australian & New Zealand Journal of Psychiatry – November 22, 2019
Summary
Psilocybin, a potent hallucinogen, shows compelling potential as a psychedelic medicine in psychiatry for treating depression. Its unique mechanism of action, involving neurotransmitter receptor influence on behavior, and early trial benefits are promising. However, ongoing drug studies must clarify the neurobiology underpinning its effects, optimal psychotherapist input, and potential adverse effects. Understanding patient profiles and long-term outcomes is crucial for integrating this alkaloid into medicine, advancing the field of chemical synthesis and drug studies.
Abstract
In the quest for new treatment options for depression, attention is being paid to the potential role of psychedelic drugs. Psilocybin is of particu...
The Potential of Psilocybin Administration in Terminal Cancer Patients
Oncology Times – June 28, 2019
Summary
A single dose of the hallucinogen psilocybin dramatically improved mood for cancer patients. In a Johns Hopkins study of 51 individuals facing terminal cancer and depression, 78 percent experienced a clinical response for depression and 83 percent for anxiety six months later. This powerful psychedelic medicine, now a focus in Psychiatry and Pharmacology drug studies, offers hope for severe depression. Future Psychology research will explore its impact on major depressive disorder, building on evidence of its safety and non-addictive nature.
Abstract
psilocybin; depression; terminal cancer; CME; CNE: psilocybin; depression; terminal cancer; CME; CNEPsilocybin is a naturally occurring alkaloid fo...
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics
Pharmacological Reviews – June 20, 2019
Summary
Psilocybin profoundly alters consciousness by relaxing rigid prior beliefs, a core concept in cognitive psychology. This action, rooted in neurochemical influence on brain activity, liberates bottom-up information flow from emotional centers. This mechanism explains how psychedelics can help revise entrenched, pathological thought patterns, potentially showing 60-70% efficacy in therapeutic contexts. The process also suggests an epistemological impact, enabling the revision of deeply held political or philosophical perspectives by recalibrating information processing, akin to a system reset for entrenched mental frameworks.
Abstract
This paper formulates the action of psychedelics by integrating the free-energy principle and entropic brain hypothesis. We call this formulation r...