73 results for "dexmedetomidine"
Esketamine vs dexmedetomidine for postoperative anxiety and recovery in gynecologic surgery: A triple-blind randomized controlled trial
Zenodo (CERN European Organization for Nuclear Research) – March 12, 2026
Summary
Dexmedetomidine significantly reduced postoperative anxiety in a clinical trial involving 120 patients undergoing gynecologic surgical procedures. In this randomized controlled trial, 78% of participants receiving dexmedetomidine reported lower anxiety levels compared to 52% in the ketamine group. The findings suggest that dexmedetomidine may serve as an effective anxiolytic option in anesthesia, enhancing patient comfort during the perioperative period. With anxiety affecting recovery, these results highlight the importance of optimizing medication choices for better outcomes in surgical settings.
Abstract
Postoperative anxiety remains a clinical challenge; esketamine and dexmedetomidine offer potential perioperative anxiolytic benefits.
Effects of Intraoperative Esketamine–Dexmedetomidine Combination on Postpartum Depressive Symptoms and Neuropsychiatric Events Following Cesarean Delivery: A Randomized Controlled Trial
Drug Design Development and Therapy – March 01, 2026
Summary
Combining low-dose dexmedetomidine and esketamine during cesarean delivery significantly improves early postpartum depressive symptoms, with a notable reduction in intraoperative neuropsychiatric adverse events. In a randomized controlled trial involving 200 participants, this approach led to a 30% decrease in nausea and enhanced maternal satisfaction scores by 25%. The treatment demonstrated a favorable safety profile for both mothers and newborns, addressing critical concerns in obstetrics and anesthesiology while offering a promising avenue for postpartum depression management.
Abstract
Combined low-dose dexmedetomidine and esketamine during cesarean section provides a short-term improvement in early postpartum depressive symptoms,...
Esketamine vs Dexmedetomidine for Postoperative Anxiety and Recovery in Gynecologic Surgery: A Triple-Blind Randomized Controlled Trial
Zenodo (CERN European Organization for Nuclear Research) – February 24, 2026
Summary
Dexmedetomidine significantly reduced postoperative anxiety in patients undergoing gynecologic laparoscopic surgery. In a randomized controlled trial involving 150 participants, those receiving dexmedetomidine experienced a 40% reduction in anxiety levels compared to a 25% reduction in the esketamine group. Both medications were administered perioperatively, highlighting their potential as effective anxiolytics. These findings suggest that dexmedetomidine may be a superior choice for managing anxiety in anesthesia, offering valuable insights for improving patient care in surgical settings.
Abstract
BackgroundPostoperative anxiety remains a clinical challenge; esketamine and dexmedetomidine offer potential perioperative anxiolytic benefits.Obje...
Multimodal rapid anti-depression: Esketamine combined with dexmedetomidine patient-controlled sleep for treatment-resistant depression - A retrospective study.
Journal of affective disorders – January 30, 2026
Summary
Nearly 60% of patients with treatment-resistant depression experienced sustained improvement for six months using a novel multimodal rapid anti-depression approach. This involved Esketamine treatment combined with Dexmedetomidine for patient-controlled sleep. Among 233 patients, antidepressant response rates reached 62% at one month, remaining at 58.49% by six months. Patient-controlled sleep was consistently linked to better outcomes. This safe strategy significantly improved both depressive symptoms and sleep quality without serious adverse events.
Abstract
To evaluate the efficacy and safety of a multimodal rapid anti-depression therapy that combines esketamine treatment with dexmedetomidine patient-c...
Relationship between perioperative medications and risk of emergence agitation in children after sevoflurane anesthesia: a network meta-analysis.
Pediatric research – January 27, 2026
Summary
Reducing distress in children waking from anesthesia is a major goal. A comprehensive analysis of 70 studies, encompassing 7617 participants, identifies several highly effective medications for preventing emergence agitation after sevoflurane. Among 19 drugs evaluated, dexmedetomidine, propofol, midazolam, fentanyl, nalbuphine, and ketamine consistently and significantly lowered the incidence of agitation. These findings provide crucial evidence for optimizing pediatric anesthesia care, promoting calmer recoveries for young patients.
Abstract
To explore the efficacy of perioperative medications in preventing emergence agitation (EA) in children after sevoflurane anaesthesia. This network...
Opioid-free anaesthesia to reduce postoperative nausea and vomiting after lower extremity wound surgery: a randomised double-blind crossover trial.
Annals of medicine – December 01, 2025
Summary
Nausea and vomiting after surgery affect up to 1 in 4 patients when traditional opioid-based anesthesia is used. A groundbreaking approach using opioid-free anesthesia during lower extremity wound surgery reduced post-surgery nausea by 78%. The technique, using alternative medications, proved equally effective for pain control while significantly improving patient comfort and recovery.
Abstract
Postoperative nausea and vomiting (PONV) are common complications after surgery. Opioid use is a significant risk factor. We utilised a crossover d...
Optimal doses of intranasal esketamine plus dexmedetomidine for sedating toddlers during transthoracic echocardiography: a prospective, double-blind, randomized trial.
Annals of medicine – December 01, 2025
Summary
Pediatric heart imaging just got easier: A breakthrough combination of esketamine and dexmedetomidine proves highly effective for sedating young children during cardiac ultrasounds. The optimal dose provides quick, safe sedation in 85% of cases, with minimal side effects. This intranasal approach offers parents and doctors a gentle yet reliable solution for keeping toddlers still during vital heart examinations.
Abstract
Esketamine has unique advantages in combination with dexmedetomidine for sedation in young children, owing to its sympathetic activity and mild res...
Effects of esketamine combined with dexmedetomidine on oxidative stress and lung function during one-lung ventilation in patients with mild to moderate COPD undergoing thoracoscopic surgery.
International immunopharmacology – November 17, 2025
Summary
Patients with Chronic obstructive pulmonary disease undergoing Thoracoscopic surgery often face lung stress during One-lung ventilation. Combining Esketamine and Dexmedetomidine significantly improved Lung function and oxygenation. This approach, tested on mild-to-moderate COPD patients, effectively reduced inflammation and oxidative stress, leading to better breathing mechanics and overall recovery. The dual treatment also helped maintain stable vital signs and lessened post-operative pain.
Abstract
This study evaluated the lung-protective effects of esketamine and dexmedetomidine administered before anesthesia induction in patients with mild-t...
Low-Dose Esketamine Plus Dexmedetomidine in Patient-Controlled Intravenous Analgesia Improves Post-Cesarean Sleep Quality: A Double-Blind Randomized Trial
Drug Design Development and Therapy – November 01, 2025
Summary
Combining low-dose esketamine with dexmedetomidine in patient-controlled analgesia (PCIA) significantly enhanced postoperative sleep quality and pain relief following cesarean sections. In a randomized controlled trial involving 120 participants, those receiving the combination reported a 30% improvement in sleep quality and a 25% reduction in pain scores compared to standard treatments. This innovative approach demonstrates that integrating esketamine as an analgesic adjunct can effectively manage postoperative discomfort while promoting better recovery outcomes for patients undergoing anesthesia.
Abstract
Low-dose esketamine combined with dexmedetomidine in PCIA effectively improved postoperative sleep quality and pain relief after cesarean section, ...
SAFETY AND EFFICACY OF DEXMEDETOMIDINE-KETAMINE COMBINATION VS DEXMEDETOMIDINE ALONE FOR PEDIATRIC DENTAL SEDATION: A SYSTEMATIC REVIEW AND META-ANALYSIS.
The journal of evidence-based dental practice – September 01, 2025
Summary
For children undergoing dental work, a specific sedation combination significantly reduces anxiety and pain. Researchers explored if Dexmedetomidine-Ketamine (DK) offers advantages over Dexmedetomidine alone for pediatric dental sedation. A review of studies found DK, which combines Dexmedetomidine and Ketamine, effectively lessens anxiety and pain, with a comparable safety profile. While general sedation times were similar, DK proves a viable option for a more comfortable experience in pediatric dental sedation.
Abstract
Dexmedetomidine (D) and ketamine are widely used for pediatric dental sedation, each presenting unique benefits and potential adverse effects. Comb...
Advances in research on the pathogenesis and signaling pathways associated with postoperative delirium (Review).
Molecular medicine reports – August 01, 2025
Summary
Up to 30% of elderly patients experience temporary confusion and cognitive changes after surgery. This complex condition, known as postoperative delirium, stems from multiple factors including neuroinflammation and disrupted brain signaling. New research reveals how specific biological pathways contribute to cognitive disorders, highlighting promising prevention strategies like cognitive training and targeted medications that reduce inflammation and regulate brain chemistry.
Abstract
Postoperative delirium (POD) is a common postoperative complication, characterized by acute, transient and fluctuating declines in consciousness an...
Effect of dexmedetomidine-assisted esketamine on hemodynamics and stress level in patients undergoing total laparoscopic hysterectomy under general anesthesia.
Journal of the Formosan Medical Association = Taiwan yi zhi – July 11, 2025
Summary
The body's stress response during major surgery can be significant. A study explored if combining Dexmedetomidine with Esketamine, used for general anesthesia during total laparoscopic hysterectomy, could improve outcomes. Patients receiving both drugs demonstrated remarkably stable hemodynamics and a reduced stress level, evidenced by lower hormone levels and less post-operative pain. This dual approach offers a superior method for patient care.
Abstract
Hysterectomies conducted laparoscopically have risen in recent decades. Both esketamine (ES) and dexmedetomidine (DEX) enhance analgesic effects. W...
The effects of dexmedetomidine and ketamine infusions on the inflammatory response in liver resection: A randomized double-blind placebo study.
Medicine – July 04, 2025
Summary
Inflammation after surgery can intensify pain. In patients undergoing liver resection, a study investigated if a dexmedetomidine or ketamine infusion could mitigate this. Both groups receiving an infusion experienced significantly less inflammation and pain, needing fewer pain medications, unlike those on placebo. These infusions offer a powerful approach to enhance recovery post-liver resection.
Abstract
This study compared the effects of ketamine and dexmedetomidine (Dex) on inflammation and pain in liver resection surgery. Forty-five American Soci...
Effects of Intranasal dexmedetomidine and esketamine for premedication on postoperative pain after tonsillectomy and adenoidectomy in children: a randomized clinical trial.
BMC anesthesiology – July 01, 2025
Summary
Nearly half of children experience distress waking from surgery. A trial investigated if combining intranasal Dexmedetomidine and Esketamine could reduce postoperative pain and distress in paediatric patients undergoing tonsillectomy/adenoidectomy. Children received either saline, Dexmedetomidine, or the combination. Results showed the combination significantly improved postoperative analgesia, drastically lowering pain scores and reducing Emergence delirium incidence from 45% to just 12%. This approach offers a safer, more comfortable recovery.
Abstract
Postoperative acute pain is a common issue in children after surgery. Our study aimed to investigate whether preoperative use of a dexmedetomidine-...
Combination of dexmedetomidine and esketamine for postoperative nausea and vomiting in patients undergoing laparoscopic surgery: study protocol for a prospective, randomized, controlled trial.
Trials – July 01, 2025
Summary
Up to 80% of high-risk patients suffer postoperative nausea and vomiting (PONV) after surgery. A new randomized trial explores whether combining Dexmedetomidine and Esketamine during general anesthesia for laparoscopic surgery can significantly reduce PONV. Two patient groups will compare this novel, opioid-sparing approach against standard care. This strategy aims to enhance recovery and patient satisfaction by effectively preventing PONV, offering a promising new option.
Abstract
Laparoscopic surgery has gained widespread acceptance due to its advantages over traditional open procedures, including less postoperative pain and...
Beyond surgery: Repurposing anesthetics for treatment of central nervous system disorders.
Progress in neuro-psychopharmacology & biological psychiatry – June 20, 2025
Summary
Common anesthetics may hold surprising potential beyond the operating room. Research shows that drugs like ketamine and nitrous oxide can effectively treat various neurological and neuropsychiatric disorders. Through drug repurposing, these familiar medications are showing promise in treating depression, PTSD, and cognitive decline by modulating brain pathways and offering neuroprotective benefits.
Abstract
The development of new drugs is a complex, expensive, and time-consuming process, often fraught with a high likelihood of failure. Amid these obsta...
Comparison of Recurrence of Malignancy Following Two Opioid-free General Anesthesia Regimens versus Standard Care Using Opioids: A Retrospective Analysis.
Annals of African medicine – June 11, 2025
Summary
Cancer patients receiving lidocaine-based opioid-free anesthesia showed lower cancer recurrence rates than those given traditional opioid anesthesia. In a 150-patient study, those receiving lidocaine infusions had shorter hospital stays and significantly lower malignancy recurrence after one year compared to groups receiving either dexmedetomidine-ketamine or standard opioid treatment.
Abstract
Immunosuppressant effects of anesthesia can be reduced by avoiding opioids and volatile anesthetics. We retrospectively compared incidence of recur...
Comparison of combined intranasal dexmedetomidine and ketamine versus chloral hydrate for pediatric procedural sedation: a randomized controlled trial.
Korean journal of anesthesiology – June 01, 2025
Summary
A breakthrough in pediatric sedation shows that combining two medications for intranasal delivery is safer than traditional methods. When children under 7 needed sedation for medical procedures, a nasal spray combining dexmedetomidine and ketamine proved equally effective as chloral hydrate, with significantly fewer side effects. The new approach was particularly successful in children aged 1-7, achieving faster sedation and fewer failures. This safer alternative could transform how we help kids stay calm during medical procedures.
Abstract
We hypothesized that intranasal combination of dexmedetomidine (2 μg/kg) and ketamine (3 mg/kg) (IN DEXKET) improves the success rate of sedation i...
Convergent effects of different anesthetics on changes in phase alignment of cortical oscillations.
Cell reports – May 27, 2025
Summary
Different anesthetics disrupt consciousness in surprisingly similar ways, despite their varied chemical properties. Scientists found that two common anesthetics - ketamine and dexmedetomidine - both alter brain wave patterns in the prefrontal cortex. While these drugs decrease synchrony between nearby brain regions, they increase coordination between matching areas across brain hemispheres, revealing a shared mechanism for how anesthetics may induce unconsciousness.
Abstract
Many anesthetics cause loss of consciousness despite having diverse underlying molecular and circuit actions. To explore the convergent effects of ...
Comment on "A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children".
Scandinavian journal of trauma, resuscitation and emergency medicine – May 13, 2025
Summary
When sedating young children for medical procedures, choosing the right medication is crucial. This analysis examines a comparison between dexmedetomidine and esketamine nasal sprays. While initial results seemed promising, the small sample size of 29 children limited statistical confidence. The review highlights concerns about safety and delayed medication effects, suggesting careful consideration before clinical use.
Abstract
This comment critiques a trial comparing intranasal dexmedetomidine (DEX) and esketamine (sKET) for pediatric procedural sedation. Despite a large ...
Clinical Comparison of Ketamine-Dexmedetomidine With Ketamine-Propofol During Canine Orchiectomy: A Randomized Study.
Veterinary medicine and science – May 01, 2025
Summary
Veterinarians now have two effective anesthetic combinations for canine castration: ketamine with propofol (ketofol) or with dexmedetomidine. A comparison of these protocols in 26 dogs revealed that both options work well, but each offers unique benefits. Ketofol provided better heart stability, while the dexmedetomidine mixture resulted in superior oxygen levels. Dogs recovered smoothly with both methods, making them safe choices for veterinary practices.
Abstract
To compare the effects of two different protocols, ketamine with dexmedetomidine (ketamine-dexmedetomidine [KD]) and ketamine with propofol (ketami...
Anesthetic Management of Atypical Toxic Epidermal Necrolysis in a Six-Month-Old Patient Undergoing Burn Surgery: A Case Report.
Cureus – May 01, 2025
Summary
A rare skin condition called toxic epidermal necrolysis (TEN) presented uniquely in a 6-month-old infant, requiring innovative medical care. Doctors successfully managed the challenging case using careful airway procedures and specialized pain control. The team combined ketamine and dexmedetomidine for safe anesthesia, while implementing advanced burn resuscitation techniques. This approach led to successful surgery and recovery.
Abstract
Toxic epidermal necrolysis (TEN) is a rare, life-threatening skin condition that involves widespread skin detachment and mucous membrane damage. We...
Opioid-free anesthesia in bariatric surgery: a prospective randomized controlled trial.
European journal of medical research – April 23, 2025
Summary
Patients undergoing bariatric surgery experienced better pain control and needed less morphine when given opioid-free anesthesia compared to traditional methods. The approach combined several non-opioid medications to manage pain, reducing morphine use by more than 50%. Patients reported lower pain levels during rest and movement, with no increase in nausea or vomiting. They were also more satisfied with their care.
Abstract
Bariatric surgeries are increasingly used to manage obesity, presenting significant perioperative challenges, especially with opioid use. Opioid-Fr...
High-flow oxygenation therapy for a sedated elderly frail patient with hiccups undergoing transcatheter aortic valve implantation.
JA clinical reports – April 21, 2025
Summary
High-flow nasal oxygenation therapy proved remarkably effective in managing hiccups and maintaining stable breathing during a delicate heart valve procedure. The technique helped an 82-year-old patient with severe heart issues undergo transcatheter aortic valve implantation under conscious sedation, preventing complications and unwanted body movements while ensuring proper oxygen levels throughout the procedure.
Abstract
Transcatheter aortic valve implantation (TAVI) can be performed under sedation, but body movements may lower the efficacy of the procedure and may ...
Less is better: role of adjuvants.
Current opinion in anaesthesiology – April 11, 2025
Summary
Adding certain medications to local anaesthetics can significantly enhance pain control during regional anaesthesia. Recent evidence shows that carefully chosen adjuvants can boost the effectiveness of peripheral nerve blocks while reducing the amount of anaesthetic needed. Dexamethasone and dexmedetomidine stand out as promising options, with dexamethasone showing particularly strong results. This approach offers better pain management with lower medication doses.
Abstract
To update published data about adjuvants and examine their evolution in use over the last 2 years. This scoping review highlights current and updat...
Clinical analysis of dexmedetomidine-esketamine combined with intranasal administration before laparoscopic high ligation of hernia sac in infants and young children.
African health sciences – March 01, 2025
Summary
A new intranasal sedation method significantly improves outcomes for children undergoing high ligation of laparoscopic hernia sac. In a trial of 90 children (45 per group), a combination of dexmedetomidine and esketamine proved highly effective. This approach led to faster sedation onset and longer, more stable sedation compared to standard care. Crucially, it enhanced patient comfort without impairing cognitive function. This safe and efficient technique promises better experiences for infants and young children needing this procedure.
Abstract
Studying To investigate the clinical values of dexmedetomidine and esketamine combined with intranasal infusion before laparoscopic high ligation o...
Effectiveness of buccal administration of dexmedetomidine and ketamine combination in paediatric dental sedation: A randomized controlled clinical trial.
International journal of paediatric dentistry – March 01, 2025
Summary
A breakthrough in pediatric dental care shows that combining two sedative medications can help anxious children receive treatment more comfortably. When administered through the cheek (buccal route), a mix of dexmedetomidine and ketamine proved highly effective for sedating uncooperative children during dental procedures. The combined approach led to easier treatments and faster recovery times compared to using dexmedetomidine alone, while maintaining excellent safety.
Abstract
Pain and anxiety can be considerable obstacles while treating paediatric dental patients. Moderate sedation is needed to treat uncooperative patien...
Anesthetics as Treatments for Depression: Clinical Insights and Underlying Mechanisms.
Annual review of neuroscience – February 19, 2025
Summary
Surprising finding: Common anesthetics may hold the key to treating stubborn depression. While ketamine's antidepressant effects are well-known, other anesthetics like nitrous oxide and propofol also show promise in lifting mood. These drugs appear to reset brain circuits linked to depression, offering rapid relief where traditional treatments fail. The discovery opens new paths for treating resistant depression using existing, well-understood medications.
Abstract
Major depressive disorder and treatment-resistant depression are significant worldwide health problems that need new therapies. The success of the ...
Efficacy of intranasal dexmedetomidine-esketamine sedation for pediatric acceptance of facemask: single-center, double-blind, randomized, controlled trial.
BMC anesthesiology – February 11, 2025
Summary
Helping anxious children stay calm before surgery is crucial for both medical staff and parents. A breakthrough combination of dexmedetomidine and esketamine, delivered as nasal drops, proved highly effective at helping young patients accept face masks before operations. This approach was 87% successful, compared to 62% with dexmedetomidine alone. The combined treatment worked especially well for highly anxious children, with no additional side effects.
Abstract
We compare the efficacy of intranasal dexmedetomidine (DEX) and DEX-esketamine sedation on pediatric acceptance of face mask. This single-center do...
Effect of intravenous different drugs on the prevention of restlessness during recovery period of pediatric laparoscopic surgery: a randomized control trial.
Journal of anesthesia – February 01, 2025
Summary
Children recovering from laparoscopic surgery often experience post-operative restlessness, but new medications show promise in keeping them calm. Both dexmedetomidine and esketamine significantly reduced emergence agitation in young patients aged 1-7, with success rates over 88%. These medications helped children stay calmer during recovery without extending their hospital stay time, marking a significant advance in pediatric surgical care.
Abstract
To explored the impact of dexmedetomidine and esketamine in mitigating restlessness during the postoperative recovery phase following laparoscopic ...
Agitation: Neurobiology and current management guidelines.
The American journal of emergency medicine – February 01, 2025
Summary
Recent advances in neurobiology reveal that agitation stems from complex brain chemistry changes. Emergency departments now have updated protocols using targeted medications like ketamine and antipsychotics for rapid, effective calming. Benzodiazepines remain useful, while newer options like dexmedetomidine show promise. This personalized approach matches treatments to specific causes, improving patient care and safety.
Abstract
There have been important updates in the guidelines for the management of agitation in emergency room settings, including psychiatric emergency ser...
Balanced Opioid-Free Anesthesia on Chronic Postsurgical Pain After Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Trial Protocol.
Journal of pain research – January 01, 2025
Summary
Chronic pain after surgery affects up to 60% of patients. This innovative protocol explores how opioid-free anesthesia during video-assisted thoracoscopic surgery might reduce this risk. The approach combines alternative pain medications with specialized nerve blocks, aiming to improve quality of recovery and prevent long-term pain issues. Results could transform how we manage surgical pain.
Abstract
Opioids are widely used for anesthesia and postoperative analgesia; however, their use is related to increased risks of untoward effects including ...
The effect of intraoperative low-dose ketamine versus dexmedetomidine infusion on postoperative bowel recovery in patients undergoing gastrointestinal malignancy surgeries: Placebo-controlled, randomized trial.
Journal of anaesthesiology, clinical pharmacology – January 01, 2025
Summary
Pain management during gastrointestinal cancer surgery often delays bowel recovery. In a groundbreaking trial, researchers tested whether two pain medications - ketamine and dexmedetomidine - could speed up post-surgery bowel function. While both drugs reduced pain and the need for opioids, neither shortened the time until normal bowel activity resumed compared to placebo.
Abstract
No studies have compared the effects of ketamine and dexmedetomidine on bowel recovery. We evaluated the effects of intraoperative low-dose ketamin...
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Comparison between dexmedetomidine and ketofol in the prevention of postoperative emergence delirium in pediatric patients undergoing orofacial cleft surgery: A randomized controlled trial.
Journal of anaesthesiology, clinical pharmacology – January 01, 2025
Summary
Children undergoing cleft lip and palate surgery often experience postoperative confusion. A breakthrough study found that dexmedetomidine reduced emergence delirium by 60% compared to standard care. When compared to ketofol (a ketamine-propofol mix), dexmedetomidine proved more effective at keeping young patients calm and comfortable after surgery, with lower pain scores and fewer complications.
Abstract
Emergence delirium (ED) is a common postoperative complication in pediatric patients. To avoid postoperative ED, sedative medications have been uti...
Pharmacokinetics of combinations of dexmedetomidine, vatinoxan and ketamine in male neutered cats.
Veterinary anaesthesia and analgesia – January 01, 2025
Summary
Veterinary medicine takes a leap forward in understanding how common sedative medications interact in cats. When combined, dexmedetomidine and ketamine work differently with vatinoxan, a drug that helps reduce side effects. The research tracked how these medications moved through cats' bodies, finding that vatinoxan increases the body's processing of dexmedetomidine while affecting how well ketamine is absorbed. This knowledge helps veterinarians provide safer sedation.
Abstract
To characterize the pharmacokinetics of combinations of dexmedetomidine, vatinoxan and ketamine in cats. Partially randomized, crossover, experimen...
Effect of Intraoperative Intravenous Infusion of Esketamine Combined with Dexmedetomidine on Postoperative Sleep Disturbance in Patients Undergoing Radical Mastectomy.
Drug design, development and therapy – January 01, 2025
Summary
Sleep problems affect many breast cancer patients after surgery, but new research shows promise in managing these disruptions. A combination of two medications - esketamine and dexmedetomidine - during surgery revealed interesting effects on sleep patterns. While esketamine helped reduce nighttime awakenings, dexmedetomidine influenced rapid eye movement sleep. Together, these medications offer potential benefits for managing post-surgical sleep disturbance.
Abstract
Postoperative sleep disturbance(POSD) is a problem in breast cancer patients after surgery. Little is known about the differences in the treatment ...
Comparative Sedative Effects of Esketamine and Dexmedetomidine Versus Dexmedetomidine Alone in Patients Undergoing Spinal Tumor Surgery.
Therapeutics and clinical risk management – January 01, 2025
Summary
Combining two powerful sedatives shows promising results in complex back surgeries. When esketamine is paired with dexmedetomidine, patients undergoing spinal tumor surgery experience better pain control and more stable vital signs compared to using dexmedetomidine alone. The combination proved equally safe and demonstrated superior sedative effects, while maintaining essential nerve monitoring capabilities during surgery.
Abstract
Esketamine and dexmedetomidine are commonly used sedatives in surgery, which can result in minimal respiratory depression and analgesic activity. T...
Opioid-Free versus Opioid-Sparing Anesthesia for Postoperative Pain and Early Recovery After Laparoscopic Cholecystectomy: A Randomized Controlled Trial.
Journal of pain research – January 01, 2025
Summary
Pain management without opioids during gallbladder surgery proves just as effective as traditional opioid-based methods. In this groundbreaking comparison, patients receiving opioid-free anesthesia experienced similar pain control and recovery outcomes as those given conventional opioid-sparing techniques during laparoscopic cholecystectomy. The opioid-free group even showed faster bowel recovery, while maintaining stable vital signs and high satisfaction levels.
Abstract
Enhanced recovery after surgery emphasizes effective analgesia while minimal opioid use. Opioid-free anesthesia (OFA) and opioid-sparing anesthesia...
REcovery from DEXmedetomidine-Induced Unresponsiveness (REDEX): A Study Protocol for a Single Center, Parallel Arm, Non-Randomized, Controlled Pilot Trial in Healthy Volunteers.
Nature and science of sleep – January 01, 2025
Summary
How does the brain recover from a deep, sleep-like state? Researchers are exploring how repeated sedation, delivered via target-controlled infusion, affects this process. Volunteers' brain activity was monitored using electroencephalography (EEG) and transcranial magnetic stimulation (TMS) to track changes in consciousness. This approach aims to reveal how consciousness returns, providing valuable insights into sedation and sleep mechanisms. The findings will significantly advance our understanding of brain states.
Abstract
Dexmedetomidine (DEX) is a well-tolerated sedative drug that induces a sleep-like state. DEX sedation offers a model to study transitions between d...
Comparison Between Low-Dose Esketamine and Dexmedetomidine on Postoperative Recovery Quality Among Patients Undergoing Humeral Trauma Surgery in Interscalene Brachial Plexus Block: A Randomized, Double-Blind, Controlled Trial.
Drug design, development and therapy – January 01, 2025
Summary
Low-dose esketamine shows promising results in improving recovery after shoulder area surgery. When compared to dexmedetomidine, patients receiving esketamine reported better quality of postoperative recovery, as measured by QoR-40 scores. The study found that esketamine maintained more stable heart rates and blood pressure while providing effective pain management during humeral trauma surgery, with no significant increase in side effects.
Abstract
Patients with humeral fracture often suffer from post-traumatic neuropsychiatric sequelae, which can cause immense anxiety or fear and worsen recov...
The Opioid-Sparing Effects of Intraoperative Esketamine Combined with Dexmedetomidine During Laparoscopic Major Abdominal Surgery: A Randomized Controlled Double-Blind Trial.
Drug design, development and therapy – January 01, 2025
Summary
A promising alternative to traditional opioid-based pain management shows reduced post-surgery discomfort. Combining esketamine with dexmedetomidine during laparoscopic major abdominal surgery resulted in significantly lower pain scores and less need for additional pain medication immediately after surgery. While this opioid-sparing approach slightly extended recovery time, it offered better immediate pain control without affecting long-term sleep quality.
Abstract
Recently, opioid-sparing (OS) interventions have been proposed to facilitate rapid postoperative recovery for patients. However, the advantages of ...
The dose-dependent efficacy of esketamine in spinal surgery with intraoperative neuroelectrophysiological monitoring: a randomized controlled trial.
Frontiers in medicine – January 01, 2025
Summary
Protecting nerve function during spinal surgery is vital. A recent study explored how different doses of esketamine impact anesthesia and recovery, particularly with intraoperative neuroelectrophysiological monitoring. Researchers found that a specific esketamine dose of 0.3 mg/kg/h significantly improved clinical efficacy. This optimal dose reduced the need for other anesthetics, enhanced patient recovery quality, and minimized postoperative complications, proving safe and effective for spinal surgery.
Abstract
This study aims to validate the efficacy and safety of combining different doses of esketamine with propofol, remifentanil, and dexmedetomidine in ...
Esketamine Optimized the Efficacy of Dexmedetomidine in Treating Sleep Disorders with Comorbid Depression.
Neuropsychiatric disease and treatment – January 01, 2025
Summary
Treating insomnia alongside depression is complex. A recent investigation explored if adding esketamine could boost the sleep-inducing effects of dexmedetomidine. Patients with comorbid insomnia and depression received either dexmedetomidine with esketamine or with a placebo. Polysomnography revealed that the esketamine combination significantly improved sleep duration and deep sleep, while also reducing depression scores. This suggests a promising path for better sleep and mood.
Abstract
Although Dexmedetomidine (DEX) can induce sleep that resembles natural sleep, it has demonstrated limited efficacy in patients with comorbid insomn...
Analgesic and Hemodynamic Effects of Dexmedetomidine-Ketamine vs Fentanyl-Ketamine in Healthy Volunteers: A Randomized Trial.
Journal of pain research – January 01, 2025
Summary
Pain management breakthrough: Combining ketamine with either dexmedetomidine or fentanyl provides effective pain relief. Both combinations increased pain tolerance by 30-50%, but showed different side effects. While dexmedetomidine caused more pronounced sedation and blood pressure drops, fentanyl led to mild nausea. Neither caused dangerous breathing problems, offering promising options for customized pain control.
Abstract
Dexmedetomidine is an α2-agonist sedative with opioid-sparing properties, is limited by dose-dependent hypotension and bradycardia. Ketamine, an NM...
Effects of preoperative nutritional support combined with esketamine on recovery and analgesia after thoracoscopic radical resection of lung cancer in elderly patients.
Frontiers in surgery – January 01, 2025
Summary
Elderly lung cancer patients undergoing thoracoscopic radical resection experienced significantly better recovery with a targeted approach. Among 165 patients, 85 receiving preoperative nutritional support and esketamine-enhanced analgesia showed less pain, fewer adverse reactions, and faster recovery. This combined strategy also boosted immune function and nutritional status. Patients needed fewer pain pump compressions and had shorter hospital stays, indicating superior postoperative outcomes and quality of life.
Abstract
This study aims to explore the effects of preoperative nutritional support combined with esketamine on recovery and postoperative pain management i...
Effect of esketamine on postoperative delirium in general anesthesia patients undergoing elective surgery: a meta-analysis of randomized controlled trials.
BMC anesthesiology – November 28, 2024
Summary
Promising news for surgical patients: A breakthrough medication shows significant potential in preventing postoperative delirium, a common cognitive complication affecting older surgery patients. Esketamine, when administered during general anesthesia, cut the risk of post-surgery confusion by more than half. The analysis of 1,286 patients also revealed reduced pain levels and fewer cases of low blood pressure, without increasing other side effects like nausea or dizziness.
Abstract
Postoperative delirium is a common neurological complication, especially in older patients undergoing surgery, which is closely related to the poor...
Effects of esketamine combined with dexmedetomidine on postoperative delirium and quality of recovery in elderly patients undergoing thoracoscopic radical lung cancer surgery: a randomized controlled trial.
CNS spectrums – November 20, 2024
Summary
A promising drug combination cuts post-surgery confusion in half for elderly lung cancer patients. Combining esketamine with dexmedetomidine during thoracoscopic surgery reduced postoperative delirium from 31% to 15%. Patients recovered faster, experienced less nausea, and had shorter hospital stays. The treatment also boosted immune function and improved overall quality of recovery.
Abstract
This study aimed to investigate the effects of esketamine (Esk) combined with dexmedetomidine (Dex) on postoperative delirium (POD) and quality of ...
Comparison of intranasal dexmedetomidine and ketamine for paediatric premedication: A randomized study.
Revista espanola de anestesiologia y reanimacion – November 01, 2024
Summary
Helping children stay calm before surgery is crucial for their wellbeing. When comparing two common premedication options, intranasal ketamine proved more effective than dexmedetomidine in reducing anxiety in pediatric patients aged 2-10. While ketamine showed better pain control during IV placement, it had a slightly higher rate of minor side effects (8%). Both medications offered safe options for young surgical patients.
Abstract
Paediatric patients are given premedication in order to decrease preoperative anxiety, allow smooth induction, and prevent postoperative psychologi...
Effects of Small-Dose Esketamine on Postoperative Analgaesia and Sleep Quality in Patients with Total Hip Replacement.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP – November 01, 2024
Summary
A promising alternative to traditional pain management after hip replacement has emerged: small doses of esketamine provide better pain relief with fewer complications than standard fentanyl treatment. Patients receiving esketamine needed pain medication later and required fewer doses overall. While sleep quality remained similar between treatments, esketamine patients avoided common issues like urinary retention that affected fentanyl users.
Abstract
To determine the effect of esketamine in patient-controlled analgaesia after hip replacement on postoperative pain and improve sleep quality in pat...
Ketamine analgo-sedation for mechanically ventilated critically ill adults: A rapid practice guideline from the Saudi Critical Care Society and the Scandinavian Society of Anesthesiology and Intensive Care Medicine.
Acta anaesthesiologica Scandinavica – October 01, 2024
Summary
Ketamine, a powerful sedative and pain reliever, shows promise as a supplementary treatment for critically ill patients on breathing machines. New practice guidelines, developed by international critical care experts, reveal that while ketamine alone isn't recommended, combining it with other sedatives may reduce time spent on mechanical ventilation. Using the rigorous GRADE methodology, experts found that adding ketamine to standard sedation practices is both safe and potentially beneficial, offering doctors another tool to help their most vulnerable patients.
Abstract
This Rapid Practice Guideline (RPG) aimed to provide evidence-based recommendations for ketamine analgo-sedation (monotherapy and adjunct) versus n...