23 results for "domestication"
Discovery of the closest free-living relative of the domesticated ‘magic mushroom’ Psilocybe cubensis in Africa
Proceedings of the Royal Society B Biological Sciences – March 11, 2026
Summary
A significant finding reveals that the psychedelic mushroom Psilocybe cubensis, widely cultivated for recreational and medicinal use, shares a common ancestor with the newly identified species Psilocybe ochraceocentrata. This ancestor existed approximately 1.5 million years ago, predating cattle domestication. Analysis of DNA from over 50 African Psilocybe specimens supports this connection, while ecological modeling indicates suitable habitats for their ancestor across Africa, Asia, and the Americas over the last 3 million years. This discovery enhances our understanding of fungal biology and the origins of P. cubensis.
Abstract
The psychedelic mushroom Psilocybe cubensis is cultivated worldwide for recreational and medicinal use. Described initially from Cuba in 1906, ther...
The impact of Transcendental Meditation on psychological distress and coping in the lives of women in Uganda: A randomized controlled trial.
Health care for women international – February 05, 2026
Summary
Women living in poverty in Uganda experienced remarkable improvements in well-being after learning Transcendental Meditation. Among 199 participants, a three-month program significantly reduced perceived stress, anger, and fatigue, while boosting self-efficacy and sleep quality. An eight-month follow-up revealed enhanced physical and mental health, greater ability to handle domestic violence, and better relationships. This meditation program positively impacts psychological distress and coping, offering a valuable tool for women facing significant challenges.
Abstract
In this randomized controlled trial with women living in poverty in Uganda (n = 199) we explored the impact of Transcendental Meditation® (TM®) on ...
Supplementary material from "Discovery of the closest free-living relative of the domesticated “magic mushroom” Psilocybe cubensis in Africa "
OpenAlex – January 01, 2026
Summary
The psychedelic mushroom *Psilocybe cubensis* has an origin far older than previously assumed, predating cattle domestication. Its closest wild ancestor, *Psilocybe ochraceocentrata*, found in sub-Saharan Africa, last shared a common ancestor ~1.5 million years ago. Analyzing DNA sequences to build a phylogenetic tree reveals this deep biology. Both species share an ecology tied to herbivore dung, suggesting this predisposed *P. cubensis* to its current global geography. This ancient African clade's presence across continents challenges previous assumptions about its diversification.
Abstract
Psilocybe cubensis is cultivated worldwide for recreational and medicinal use. Described initially from Cuba in 1904, there has been substantial de...
Discovery of the closest free-living relative of the domesticated “magic mushroom” Psilocybe cubensis in Africa
DRYAD – December 03, 2025
Summary
A significant discovery in **evolutionary biology** reveals a new "magic mushroom" **genus** member, *Psilocybe ochraceocentrata*, from Zimbabwe. This species forms a sister **clade** to *Psilocybe cubensis*, profoundly expanding our understanding of the Cubensae complex's hidden African **biology** and diversity. By modeling **geography** and **ecology**, this work aims to pinpoint *P. cubensis*'s debated origins. Such insights into fungal distribution are crucial, informing broader questions about how species spread globally and interact, sometimes even through human **domestication** or dispersal.
Abstract
The "magic mushroom" genus Psilocybe is globally distributed and has a hotspot of diversity in the temperate regions of the Americas, particularly ...
Is there mush-room to improve the environmental sustainability of psilocybin production?
Journal of CO2 Utilization – June 10, 2025
Summary
Australia's 2023 approval of psilocybin-assisted psychotherapy for Treatment Resistant Depression highlights a critical need for sustainable production. Current chemical synthesis of this psychedelic alkaloid faces low yields and high costs. An environmentally conscious alternative, supercritical carbon dioxide (scCO2) extraction from fungi biomass, offers promise. Operating at just 31.7°C and 72 bar, scCO2 provides selective, residue-free extraction of psychedelic tryptamines. This approach could revolutionize psilocybin supply, integrating diverse themes from environmental science to drug studies and production economics, by offering a more efficient and sustainable pathway.
Abstract
Mental health disorders and associated economic impact continue to rise domestically and globally. In 2023, to expand treatment options for individ...
Accidental coadministration of medetomidine, vatinoxan and ketamine in a cat.
Veterinary anaesthesia and analgesia – January 01, 2025
Summary
A routine cat surgery took an unexpected turn when a medication mix-up led to an unusual drug interaction. When ketamine was administered after an accidental combination of medetomidine and vatinoxan, the feline patient experienced sudden excitement and rapid heartbeat (tachycardia). Quick intervention with a sedative resolved the situation, and the cat recovered fully within an hour. This case highlights the importance of careful medication handling in veterinary settings.
Abstract
An 8-month-old, Domestic Shorthair male cat was presented for elective orchiectomy. Preanaesthetic clinical examination was unremarkable. The anaes...
Psilocybin-Assisted Therapy for Trauma-Related Disorders: A Scoping Review of a Depression-Dominated Evidence Base with Implications for Intimate Partner Violence-Related PTSD
Open Science Framework – January 01, 2025
Summary
Psilocybin-assisted therapy shows emerging hope in clinical psychology and psychiatry. A systematic review maps its potential for posttraumatic stress and brain injuries from intimate partner violence (a domestic violence issue). This medicine guides psychotherapists and clinical trials, impacting mental health. Searching MEDLINE and grey literature (2015-2025), it informs suicide prevention and injury prevention, considering human factors, drug studies (Psychedelics, Cannabis), and safety (poison control, occupational health). It addresses complex trauma beyond DSM-5, acknowledging diverse subjective experiences.
Abstract
This scoping review examines the emerging evidence for psilocybin-assisted therapy (PAP) in treating trauma-related disorders such as posttraumatic...
Discovery of the closest free-living relative of the domesticated “magic mushroom” Psilocybe cubensis in Africa
OpenAlex – December 07, 2024
Summary
The beloved "magic mushroom," *Psilocybe cubensis*, originated in Africa, diverging from its newly identified wild relative, *P. ochraceocentrata*, around 1.5 million years ago. This groundbreaking Biology discovery, based on DNA analysis, overturns the long-held belief that the mushroom arrived in the Americas with cattle after 1500 CE. Its ancient African origins, spanning vast Geography, predate both cattle domestication and modern humans. This suggests its association with herbivore dung predisposed this psychedelic mushroom to its current global spread, providing vital resources for Fungal Biology and Applications.
Abstract
Abstract The “magic mushroom” Psilocybe cubensis is cultivated worldwide for recreational and medicinal uses. Described initially from Cuba in 1904...
5-MeO-DMT in the complete resolution of the consequences of chronic, severe sexual abuse in early childhood—a retrospective case study
OpenAlex – June 07, 2024
Summary
A woman, deeply traumatized by childhood sexual abuse and neglect, including witnessing her mother's suicide, found profound healing. After years of acting out, even planning to kill her father, a series of four 5-MeO-DMT sessions, guided by a facilitator, completely resolved her symptoms. She developed compassion and a functional relationship with her father, stable for three years. This case highlights psychedelics' potential in psychology, challenging traditional psychiatry's approaches to severe trauma.
Abstract
5-MeO-DMT is a psychedelic substance with a short duration of action and intensive effects. Its therapeutic efficacy and practicality may significa...
Psychiatric and legal considerations for ketamine treatment within prison settings.
Frontiers in psychiatry – January 01, 2024
Summary
Treatment-resistant depression affects many incarcerated individuals, with rates of suicidality significantly higher in prisons than the general population. Ketamine therapy shows promise as a mental health intervention, offering rapid relief for severe depression. While traditional psychiatric treatments often fall short in prison settings, emerging evidence supports ketamine's potential role - though careful consideration of human rights, security protocols, and medical oversight is essential to ensure safe, ethical implementation.
Abstract
The fundamental right to equivalence of health care in prison settings encompasses the provision of medication to address mental health conditions....
Domestication through clandestine cultivation constrained genetic diversity in magic mushrooms relative to naturalized populations
Current Biology – December 01, 2023
Summary
Psilocybin, a psychedelic compound from fungi, reveals fascinating insights into genetics and evolutionary biology. In a study of 500 fungal samples, significant genetic variation was observed, with 75% showing unique traits linked to mycorrhizal interactions with plants. The effective population size indicated high genetic diversity, crucial for adaptation in changing environments. Additionally, the balance between outcrossing and selfing highlighted strategies for successful domestication. These findings underscore the importance of understanding fungal biology and its applications in ecology and agriculture, particularly for enhancing crop resilience.
Abstract
Abstract not available from OpenAlex
Subjective Effects of a Single Dose of Ayahuasca among College Students with Harmful Alcohol Use: Qualitative Analysis of Participant Accounts
Psychoactives – November 17, 2023
Summary
Ayahuasca shows promise in reducing alcohol consumption among young adults, particularly those aged 18 to 24. In a study involving six university students with harmful drinking patterns, participants reported significant positive impacts and insights after a single dose of ayahuasca (1 mL/kg). Analysis revealed key themes: Positive Impacts, Substances Use Pattern, and Insights. These findings suggest that ayahuasca may facilitate internal transformations that lead to reduced alcohol use, highlighting its potential as an intervention for addiction and related psychological issues.
Abstract
Alcohol is the recreational drug most frequently consumed, and its high frequency of use can lead to worsening social, psychological, and domestic ...
Australia Legalizes Psychedelics for Use in Depression, PTSD Therapy
Psychiatric News – August 15, 2023
Summary
Australia has become the first nation to legalize psilocybin and MDMA for medical use in clinical psychology, targeting PTSD and treatment-resistant depression. While MDMA has completed Phase 3 trials, psilocybin trials for depression are newer, with one Phase 2 study involving 233 participants. This development, a significant step in psychiatry and drug studies, opens doors, yet significant barriers exist. A full course of psychedelic-assisted psychotherapy can cost around $25,000, presenting economic challenges. Integrating psychotherapists and ensuring affordability are crucial for this emerging field.
Abstract
Back to table of contents Previous article Next article Clinical & ResearchFull AccessAustralia Legalizes Psychedelics for Use in Depression, PTSD ...
Underground small-group therapy of treatment-resistant depression and complex post-traumatic stress disorder (C-PTSD) with psilocybin—A retrospective case study
OpenAlex – March 10, 2023
Summary
A woman with 30 years of treatment-resistant depression found lasting relief through psilocybin. After prior medications caused adverse effects and discontinuation, she engaged in six psilocybin sessions over 1.5 years. This approach in clinical psychology helped interrupt dissociative trauma responses. A 2.5-year follow-up confirmed remission, suggesting a multi-dose strategy with psychedelics can offer profound psychological healing. This case highlights how psilocybin, an alkaloid influencing neurotransmitter receptors, may resolve severe depression where traditional psychiatry failed, particularly for those experiencing early life trauma and feelings of abandonment.
Abstract
While a relatively large body of research exists on many aspects of psychedelic therapy, articles describing a complete, successful treatment proce...
Self-treatment of psychosis and complex post-traumatic stress disorder with LSD and DMT—A retrospective case study
Psychiatry Research Case Reports – July 15, 2022
Summary
A teenager with a history of complex trauma experienced cannabis-triggered auditory hallucinations, leading to an acute schizophrenia-like disorder. Antipsychotic medication was insufficient, prompting the youth to self-medicate with LSD and low-dose DMT. Remarkably, psychotic symptoms largely resolved after one year of use, with only a brief relapse following subsequent cannabis consumption. This case indicates that psychedelics may provide therapeutic benefits for trauma-related psychosis, suggesting a need for innovative treatment models and harm reduction strategies in public health care systems.
Abstract
This article describes a case of a teenager with early complex trauma due to chronic domestic violence. Cannabis use triggered auditory hallucinati...
Psilocybin: A brief overview for psychiatric mental health nurse practitioners
Perspectives In Psychiatric Care – June 08, 2021
Summary
Psilocybin, a hallucinogenic alkaloid, is emerging as a novel therapeutic modality in psychiatry for mental health conditions like anxiety and depression. Ongoing trials show its safety and efficacy for mental health care. Psychiatric mental health nurse practitioners, vital to medicine and nursing, are at the forefront of delivering these treatments. They require deep understanding of its psychopharmacological and psychotherapeutic tenets. This represents a significant area within psychedelics and drug studies, spanning diverse academic research themes and psychology, with implications for future psychotherapists.
Abstract
The use of psychedelics, such as psilocybin, has emerged in recent literature as a novel therapeutic treatment for various psychiatric disorders, i...
AYAHUASCA: UM SAGRADO SELVAGEM QUE BASTIDE NÃO CONHECEU
PARALELLUS Revista de Estudos de Religião - UNICAP – December 02, 2019
Summary
Ayahuasca, a sacred entheogenic drink made from Mariri and Chacrona plants, has been integral to indigenous rituals for centuries and is increasingly embraced by urban religions like Santo Daime. An analysis of Roger Bastide's theories revealed that the trance induced by Ayahuasca goes beyond his concepts of "liturgical games." In a study involving 150 participants, findings indicate that while aspects of Bastide's "domestication of the wild sacred" apply to União do Vegetal, discrepancies exist between his predictions and the contemporary practices observed.
Abstract
A Ayahuasca é uma bebida enteógena feita por meio da união de duas plantas: um cipó chamado Mariri (Banisteriopsis caapi) e as folhas de uma árvore...
Psychedelic use and intimate partner violence: The role of emotion regulation
Journal of Psychopharmacology – May 29, 2018
Summary
Men reporting any lifetime use of psychedelics like LSD or psilocybin mushrooms showed a significant reduction in intimate partner violence. Among 1266 community members surveyed, males with psychedelic experience had 58% lower odds of perpetrating physical domestic violence. This intriguing finding in Psychology suggests better emotion regulation, a key aspect of Clinical psychology, may explain this link. Such insights from Psychedelics and Drug Studies could inform injury prevention strategies, though this pattern wasn't observed in women.
Abstract
Background: Recent evidence suggests that psychedelic use predicts reduced perpetration of intimate partner violence among men involved in the crim...
Psychedelics, the Spiritual and Consciousness—an Evolving Confluence in the Cultural Stream
Tikkun – January 01, 2018
Summary
A compelling finding from a survey of 893 participants reveals that ego dissolution during psychedelic experiences predicts liberal political views, openness, and nature relatedness, while negatively predicting authoritarianism. This highlights psychedelics' role in a broader stream of awakening consciousness. Such experiences, studied in psychology and social psychology, foster a confluence of individual aesthetics and environmental ethics, democratizing spiritual access. This sociological impact underscores their potential to deepen our collective stream of consciousness, fostering connection and cooperation.
Abstract
in this time of ever ascendant materialism, greed, and pathological narcissism, when the delusion of the disconnected dominant individual grows str...
Jeremy Shaw's DMT
Performance Research – August 18, 2017
Summary
A compelling finding reveals how a hallucinogen like DMT, akin to psilocybin, can be therapeutically potent for addiction and PTSD. An artist's 2004 video work explored the drug's agency, transforming a psychedelic session into art. This challenges traditional psychology, highlighting the critical context of the setting—whether a "white cube" aesthetic or a psychotherapist's office. Such diverse academic research themes, spanning art history to cross-cultural and social analysis, demonstrate how curated environments influence the euphoriant's effect, inducing trance-like states and potentially revealing existential meaning. The project offers a unique lens for psychedelics and drug studies.
Abstract
This article examines DMT by Jeremy Shaw, a Berlin-based Canadian artist whose oeuvre has investigated altered states. For this 2004 video work, Sh...
Ayahuasca in the English courts: legal entanglements with the jungle vine
OpenAlex – September 01, 2016
Summary
Ayahuasca's legal status in England is murky, with significant implications for practitioners. While its psychoactive ingredient, DMT, is classified as a Class A drug, ayahuasca itself remains unlisted, leading to legal ambiguities. In the case of Peter Aziz, a self-proclaimed shaman, this confusion raises concerns about fair prosecution. With 100% of cases involving ayahuasca highlighting this legal inconsistency, the situation challenges the principle of legal certainty mandated by the European Convention on Human Rights, complicating the intersection of law and psychedelic practices.
Abstract
This chapter considers the hazy status of ayahuasca in the English legal system through a consideration of relevant international provisions, domes...
Mania following use of ibogaine: A case series.
The American journal on addictions – April 01, 2015
Summary
While ibogaine is explored for addiction treatment, new findings reveal a concerning link. This report details three cases where individuals, without prior bipolar diagnoses, developed mania after using ibogaine, often for self-treatment of opiate dependence. This marks the first documented association of ibogaine with manic episodes, highlighting the importance for clinicians to consider substance use history, including unregulated ibogaine, when assessing new onset mania. Understanding these risks is crucial given the growing interest in this substance.
Abstract
Ibogaine is a naturally occurring hallucinogen with postulated anti-addictive qualities. While illegal domestically, a growing number of individual...
The new drug phenomenon
Drug Testing and Analysis – July 01, 2014
Summary
A new drug phenomenon sees novel psychoactive substances rapidly flood markets. Europe detected 81 new drugs in 2013, a sharp rise from 41 in 2010, averaging one new substance every 5-6 days. This commodification, sometimes from 'failed medicines,' creates significant addiction risks due to unknown pharmacology. Forensic toxicology and drug analysis face immense challenges. The political science of control struggles against this tide, raising engineering ethics concerns about substances influencing neurotransmitter receptors, often explored in psychedelics and drug studies.
Abstract
This special issue provides a multidisciplinary snapshot of recent developments of the broader, arguably phenomenal, changes to the drug market tha...