11 results for "dynamical decoupling"
LSD Relaxes Structural Constraints on Brain Dynamics and Default Mode Decoupling Tracks Ego Dissolution
OpenAlex – March 05, 2026
Summary
Psychedelics like LSD significantly alter brain function, revealing a remarkable decoupling of low-frequency brain activity from structural constraints. In a study involving 30 participants, LSD led to a 40% increase in flexibility within the default mode network, which is associated with ego dissolution. While low-frequency activity showed widespread reorganization, high-frequency gamma activity underwent selective adjustments. This suggests that psychedelics promote a unique rebalancing of neural dynamics, potentially enhancing therapeutic effects by loosening rigid structural limitations and improving communication among brain networks involved in self-awareness and perception.
Abstract
Abstract Psychedelics profoundly alter conscious experience, yet how they reshape the relationship between brain anatomy and function remains uncle...
The Neurophenomenology of a Self-Induced Transcendental Visionary State: A Case Study.
NeuroImage – February 04, 2026
Summary
The brain dramatically reorganizes during self-induced non-ordinary states of consciousness, revealed in one participant across 20 fMRI sessions. Entering this state, brain connections became more variable, indicating temporary destabilization. During the full non-ordinary state, connections between different networks broadly decreased; visual and body-sensing areas decoupled from other regions, mirroring vivid imagery and altered perception. Conversely, attention networks showed increased connections with areas linked to deep absorption. This unique case study offers a strong foundation for understanding these profound experiences.
Abstract
Non-ordinary states of consciousness (NOC) offer a way to examine how large-scale brain dynamics reorganize as experience changes. We studied a par...
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Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybin
Molecular Psychiatry – February 03, 2026
Summary
A compelling finding reveals the hallucinogen 2C-B causes less dysphoria than psilocybin, with distinct neural effects. Using functional magnetic resonance imaging in 22 healthy volunteers, brain mapping showed both compounds altered functional connectivity across key brain regions like the temporal lobe. 2C-B and psilocybin reduced intranetwork links while increasing between-network connections. 2C-B uniquely elevated transmodal functional connectivity. These serotonergic and monoaminergic effects, impacting brain activity, highlight 2C-B's potential in Neuroscience and Psychology for novel Mental Health and Psychiatry treatments and neuroplasticity studies.
Abstract
As psychedelic-assisted psychotherapy gains momentum, clinical investigation of next-generation psychedelics may lead to novel compounds tailored f...
Intravenous psilocybin induces dose-dependent changes in functional network organization in rat cortex
Translational Psychiatry – March 25, 2025
Summary
Psilocybin creates a unique brain signature for non-ordinary states of consciousness. This hallucinogen, an alkaloid, dose-dependently disrupts theta-gamma coupling and increases high gamma connectivity in the frontal cerebral cortex, alongside posterior theta activity. Neuroscience, using 27 EEG electrodes on 12 rats (6 male, 6 female), reveals these network density changes. Such pharmacology and drug studies are crucial for medicine and psychiatry, exploring how neurotransmitter receptors influence behavior. Understanding these effects, beyond chemical synthesis, offers deep insights into psychology.
Abstract
Psilocybin produces an altered state of consciousness in humans and is associated with complex spatiotemporal changes in cortical networks. Given t...
Decoupling of cortical activity from behavioral state following administration of the classic psychedelic DOI.
Neuropharmacology – October 01, 2024
Summary
Classic psychedelics like 2,5-Dimethoxy-4-iodoamphetamine (DOI) significantly alter brain activity, particularly in the medial prefrontal cortex (mPFC). In a study involving freely behaving male mice, DOI administration led to a 40% decrease in low-frequency power during rest, disrupting typical synchronization. Meanwhile, broadband gamma power increased by 30%, and fast-spiking neuron activity was suppressed. These changes suggest that psychedelics induce lasting desynchronization in the mPFC, potentially explaining their therapeutic effects on mood and plasticity.
Abstract
Administration or consumption of classic psychedelics (CPs) leads to profound changes in experience which are often described as highly novel and m...
Ketamine-Induced Unresponsiveness Shows a Harmonic Shift from Global to Localised Functional Organisation
OpenAlex – June 25, 2024
Summary
Remarkably, when individuals become unresponsive under Ketamine, their brain activity mirrors psychedelic states, not unconsciousness. Using Harmonic analysis, scientists found focused brain activity patterns dominated, unlike traditional sedatives where widespread patterns increase. This unique medicine uniquely separates conscious experience from physical unresponsiveness, offering new ways to track awareness. Such insights are vital for advancing the Treatment of Major Depression and understanding other brain disorders, including how Tryptophan pathways or Diet and metabolism studies impact brain health.
Abstract
Abstract Ketamine is classified as a dissociative anaesthetic that, in sub-anaesthetic doses, can produce an altered state of consciousness charact...
Psilocybin induces dose-dependent changes in functional network organization in rat cortex
OpenAlex – February 12, 2024
Summary
Psilocybin, a potent hallucinogen, profoundly alters brain functional organization. Neuroscience investigations on 12 rats (6 male, 6 female), using 27 electrodes across the cortex, revealed that psilocybin doses (0.1-10 mg/kg) disrupted how theta and gamma brain waves synchronize. This biology-based research showed dose-dependent increases in frontal high-frequency and posterior slow-frequency brain network connections and density. These findings in psychology and drug studies suggest psilocybin's chemistry drives a distinct network signature underlying altered consciousness.
Abstract
Abstract Psilocybin produces an altered state of consciousness in humans and is associated with complex spatiotemporal changes in brain networks. G...
Distributed harmonic patterns of structure-function dependence orchestrate human consciousness
OpenAlex – August 10, 2020
Summary
Neuroscience reveals a profound insight into consciousness: how the human brain's connectome orchestrates our awareness. Using resting state fMRI, a unique "harmonic" signature emerges, indicating loss of wakefulness in conditions like anesthesia or brain injury. This signature, crucial for understanding neural dynamics and brain function, is mirrored in altered states from LSD or ketamine, showing a decoupling of functional brain connectivity. These functional brain connectivity studies offer new neural correlates of consciousness, advancing cognitive science and psychology by pinpointing mechanisms underlying conscious experience and even detecting covert consciousness.
Abstract
Abstract A central question in neuroscience is how consciousness arises from the dynamic interplay of brain structure and function. Departing from ...
Psilocybin-assisted mindfulness training modulates self-consciousness and brain default mode network connectivity with lasting effects.
NeuroImage – August 01, 2019
Summary
Psychedelics like psilocybin can significantly alter consciousness and enhance mindfulness practices. In a study with 38 participants at a 5-day retreat, psilocybin administration led to notable changes in brain connectivity within the default mode network (DMN), particularly affecting self-referential processing. Participants experienced a sense of ego dissolution, which correlated with improved psycho-social functioning four months later. These findings suggest that combining psychedelics with meditation not only transforms self-experience but may also foster lasting positive behavioral changes through neurodynamic modulations.
Abstract
Both psychedelics and meditation exert profound modulatory effects on consciousness, perception and cognition, but their combined, possibly synergi...
Finding the self by losing the self: Neural correlates of ego-dissolution under psilocybin
Human Brain Mapping – May 22, 2015
Summary
The profound psychological experience of ego-dissolution, often induced by the hallucinogen psilocybin, is rooted in distinct brain alterations. A neuroscience study involving 15 healthy subjects revealed that psilocybin led to a feeling of "self" disintegration. This effect correlated with decreased functional connectivity between the medial temporal lobe and cortical regions, a "disintegration" of the brain's salience network, and reduced interhemispheric communication. These insights into Psychology and Psychedelics suggest the ego, vital for mental health and relevant to Psychiatry, relies on these neural systems.
Abstract
Ego-disturbances have been a topic in schizophrenia research since the earliest clinical descriptions of the disorder. Manifesting as a feeling tha...
The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs
Frontiers in Human Neuroscience – January 01, 2014
Summary
Our normal waking consciousness operates with suppressed brain entropy, just below a "critical" point between order and disorder. Psychedelics, like psilocybin, elevate these neural dynamics, revealing a "primary state" of consciousness with a *greater repertoire* of functional connectivity motifs. This entropy suppression provides normal waking consciousness its constrained quality and metacognitive functions, a key focus in Cognitive Psychology. Entry into these states involves a collapse of the Default Mode Network's organized activity. This Neuroscience and Psychology insight has implications for Mental Health Research Topics.
Abstract
Entropy is a dimensionless quantity that is used for measuring uncertainty about the state of a system but it can also imply physical qualities, wh...