3 results for "grading engineering"
Efficacy of 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy for posttraumatic stress disorder: A systematic review and meta-analysis of clinical and functional outcomes
European Neuropsychopharmacology – March 12, 2026
Summary
MDMA-assisted therapy shows promise for reducing PTSD symptoms, with a notable effect size of -1.19 across nine trials involving 298 participants. Additionally, it may alleviate dissociative symptoms (effect size -0.37) and enhance overall functioning (effect size -0.83). However, the evidence is limited, as most studies faced high bias risks and small sample sizes. Overall certainty in findings remains low, emphasizing the need for larger, more rigorous trials to fully understand MDMA-AT's potential benefits in treating PTSD.
Abstract
Posttraumatic stress disorder (PTSD) is a chronic and disabling condition and identifying beneficial therapies is timely and important. We aimed to...
CNSC-36. PSILOCYBIN INDUCES SUSTAINED GLIOMA GROWTH THROUGH SEROTONERGIC AND TRKB PATHWAYS
Neuro-Oncology – November 01, 2025
Summary
Psilocybin, a psychedelic gaining interest for cancer patients, significantly boosted aggressive brain tumor growth. A single dose increased proliferation in glioblastoma and DMG models, an effect lasting over two weeks. Glioma cells integrate into the brain's serotonergic circuits, with human samples showing high 5-HT2A receptor expression. Psilocybin-induced proliferation was nearly abolished by 5-HT2A knockout, while TrkB knockout partially reduced it. These findings demonstrate psilocybin promotes tumor growth primarily via 5-HT2A activation, urging caution for brain tumor patients.
Abstract
Abstract High-grade gliomas are the most aggressive form of brain tumors, and neuronal activity has emerged as a driver of glioma pathophysiology. ...
Extraction Yields of Psilocybin and Psilocin: A Short Review of Current Methods and Their Implications
Pharmaceuticals – March 07, 2025
Summary
Producing pharmaceutical-grade psilocybin, a promising psychedelic alkaloid, is challenging despite its therapeutic potential. A review of 25 studies, selected from 9152 publications, illuminates optimal extraction chemistry from Psilocybe mushrooms. Ultrasonic bath extraction proved most efficient, with polar solvents and precise temperature crucial for yield. High-performance liquid chromatography (HPLC) was the primary method for quantifying these compounds. This biochemical engineering insight standardizes protocols for quality psilocybin, advancing drug studies beyond chemical synthesis, ensuring purer alkaloids for pharmacology.
Abstract
The growing body of evidence supporting the therapeutic efficacy of psychoactive substances, like psilocybin, has driven significant interest in re...