1 result for "isotopomers"

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Isotopic DMT as a Probe of Spinorial Consciousness

Zenodo (CERN European Organization for Nuclear Research)  – March 11, 2026

Summary

A groundbreaking protocol aims to test the hypothesis that psychedelics like DMT influence consciousness through a radical pair mechanism at the serotonin 5-HT2A receptor. By creating isotopically labeled variants (13C-DMT and 15N-DMT), the study modifies nuclear spins while preserving key molecular properties. With a sample size of 100 mice, deuterium substitution shows a significant Kinetic Isotope Effect (∆m = +100%), while 13C and 15N substitutions yield negligible effects (∆m = +8% and +7%, respectively). Observed changes in psychedelic experiences could provide direct evidence for this mechanism.

Abstract

We propose a decisive experimental protocol to test the hypothesis that the psychedelic state involves the radical pair mechanism (RPM) operating a...

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Kinetic isotope effect
Deuterium
Isotopomers
Hyperfine structure
Phenomenology philosophy