9 results for "leverage statistics"
State of the Science: MDMA‐assisted psychotherapy for the treatment of posttraumatic stress disorder
Journal of Traumatic Stress – March 12, 2026
Summary
MDMA-assisted psychotherapy has shown remarkable promise for treating posttraumatic stress disorder (PTSD), with response rates exceeding 60% and remission rates around 40% in recent trials involving over 300 participants. Despite these encouraging results, the U.S. Food and Drug Administration denied market approval in August 2024 due to concerns about evidence gaps. This review highlights methodological limitations, such as blinding challenges and a lack of active comparators, while suggesting future research should integrate MDMA with established trauma-focused therapies to enhance cognitive behavioral outcomes.
Abstract
There is growing interest in novel approaches to treating posttraumatic stress disorder (PTSD), including the use of psychedelic substances combine...
Dissecting Cardiovascular Responses to a Fixed-Interval Volitional Sighing Protocol Using a Mixed Modeling Approach.
Psychophysiology – January 01, 2026
Summary
Sighing can act like a cardiovascular stress test, revealing early health changes. In 250 healthy college students (65% female), rhythmic breathwork significantly increased heart rate and blood pressure, with more intense responses during faster sighing (one sigh every 15 seconds vs. 30 seconds). This protocol, which also impacts heart rate variability and pulse, consistently activates the body's 'fight or flight' response. Respiration changes detected person-specific differences, especially between sexes, suggesting sighing could uncover early cardiovascular or nervous system issues.
Abstract
Sighing generates a reliable sympathetic cardiovascular response that, like exercise, could be leveraged in a graded "stress test" to reveal precli...
Psilocybin-assisted neurofeedback for the improvement of executive functions: a randomized semi-naturalistic-lab feasibility study
Philosophical Transactions of the Royal Society B Biological Sciences – October 21, 2024
Summary
Individuals receiving psilocybin-assisted neurofeedback reported significant self-reported improvements in daily executive functions, crucial for mental health and physical medicine and rehabilitation. This novel treatment, leveraging neuroplasticity and neurotransmitter receptor influence on behavior, involved 37 participants. The 18 individuals in the experimental group experienced substantial gains in working memory and inhibition (medium to high effect sizes). This development in Psychology and Psychedelics and Drug Studies offers a new avenue for addressing anxiety and depression by enhancing neurocognitive processes, validated through psychometrics.
Abstract
Executive function deficits, common in psychiatric disorders, hinder daily activities and may be linked to diminished neural plasticity, affecting ...
Psychedelic-assisted psychotherapy: Where is the psychotherapy research?
OpenAlex – November 06, 2023
Summary
Despite the widespread assumption that psychotherapeutic support is vital for psychedelic-assisted medicine, there's a striking absence of empirical data on its specific role. As clinical trials for these compounds, influencing neurotransmitter receptors, transition to evaluating efficacy for mental health, understanding the psychotherapist's role in this intervention becomes paramount. Future designs must leverage insights from psychology to standardize counseling, optimizing outcomes and informing best practices for this unique drug study bridging medicine and mental health.
Abstract
Rationale: Psychedelic-assisted psychotherapy (PAP) has emerged as a potential treatment for mental health conditions, such as substance use disord...
Psilocybin-assisted neurofeedback for the improvement of executive functions: a randomised semi-naturalistic-lab feasibility study
OpenAlex – October 11, 2023
Summary
Daily executive functions significantly improved for individuals undergoing psilocybin-assisted neurofeedback. This approach, combining a potent psychedelic from chemical synthesis with targeted brain training, leverages neuroplasticity to enhance mental flexibility. In a group of 18 participants, self-reported gains in working memory and inhibition showed medium to high effect sizes. While 19 controls also reported some benefits, the experimental group achieved their key training goals. This suggests a promising avenue in Psychology and Physical medicine and rehabilitation, exploring neurotransmitter receptor influence on behavior through novel Psychedelics and Drug Studies.
Abstract
Executive function deficits, common in psychiatric disorders, hinder daily activities and may be linked to diminished neural plasticity, affecting ...
Bayesian analysis of real‐world data as evidence for drug approval: Remembering Sir Michael Rawlins
British Journal of Clinical Pharmacology – July 17, 2023
Summary
A compelling 95% probability of success was observed for medical cannabis in treating childhood epilepsy, with all 20 patients improving. This demonstrates how Bayesian probability, leveraging real-world data, offers crucial insights for medicine and drug studies. For psychedelics like psilocybin, favorable responses for depression reached 82%. This computational approach, incorporating prior probability, efficiently informs individual treatment efficacy—a critical step for understanding pharmacogenetics and drug metabolism, often requiring fewer patients than traditional 170-patient trials.
Abstract
The two pillars of modern medical research are where in most randomized controlled trials (RCTs), the active treatment is compared with placebo. A ...
Cannabis-assisted psychotherapy for complex dissociative posttraumatic stress disorder: A case report
Frontiers in Psychiatry – February 09, 2023
Summary
A young woman with complex dissociative posttraumatic stress disorder achieved a 98.5% reduction in pathological dissociation after ten sessions of cannabis-assisted psychotherapy. This psychotherapist-guided treatment combined cognitive and exposure therapies to address severe depersonalization and derealization, common in dissociative and panic disorders. Improved cognition and psychosocial functioning were sustained for over two years. Offering a promising avenue for clinical psychology and psychiatry, it links cannabis to psychedelics and their Neurotransmitter Receptor Influence on Behavior.
Abstract
Background A dissociative subtype of posttraumatic stress disorder, known as “D-PTSD”, has been included in the Diagnostic and Statistical Manual o...
Group VR experiences can produce ego attenuation and connectedness comparable to psychedelics
Scientific Reports – May 30, 2022
Summary
Virtual reality can induce profound experiences akin to psychedelics, dissolving the ego and fostering social connectedness. A new VR framework, Isness-D, leverages computer science and embodied cognition, allowing 58 participants to merge their virtual selves. This unique affordance creates a shared phenomenology, where individuals perceive their bodies as energetic essences, blurring self-other boundaries. Scores on psychological scales measuring ego-dissolution and mystical experiences were indistinguishable from those reported in psychedelic drug studies. This demonstrates VR's power to cultivate deep intersubjective connections, transforming the self through virtual interaction.
Abstract
Abstract With a growing body of research highlighting the therapeutic potential of experiential phenomenology which diminishes egoic identity and i...
Homological scaffolds of brain functional networks
Journal of The Royal Society Interface – October 29, 2014
Summary
Psilocybin dramatically alters the brain's functional connectivity, revealing many transient patterns not seen with placebo. A novel approach, leveraging Mathematics and Theoretical computer science, uses Topological and Geometric Data Analysis to study brain networks, moving beyond traditional node centrality and modularity. This method analyzed brain activity in 15 healthy volunteers, offering new insights for Psychedelics and Drug Studies and Mental Health Research Topics. It could also inform Artificial intelligence for pattern recognition in Computer science.
Abstract
Networks, as efficient representations of complex systems, have appealed to scientists for a long time and now permeate many areas of science, incl...