110 results for "perioperative"
Ketamine as primary anesthetic for upper limb trauma during war: a case series of 100 surgeries at Rafik Hariri University Hospital, Lebanon's National War Trauma Referral Center.
Future science OA – December 01, 2026
preprint
Summary
Following the Beirut pager explosions, trauma anesthesia at RHUH for 100 amputation surgeries dramatically improved with ketamine. Initially, opioid-based care led to 18 respiratory complications and 65% postoperative opioid use. After ketamine's introduction for mass casualty patients, pain scores dropped from 7.8 to 3.2, respiratory complications became zero, and only 5% required postoperative opioids. This opioid-sparing approach, crucial for conflict medicine, maintained stable blood pressure in 94% of patients, highlighting ketamine's effectiveness.
Abstract
The Beirut pager explosions on September 17, 2024 resulted in mass casualties with severe upper limb trauma admitted to Rafik Hariri University Hos...
Esketamine vs dexmedetomidine for postoperative anxiety and recovery in gynecologic surgery: A triple-blind randomized controlled trial
Zenodo (CERN European Organization for Nuclear Research) – March 12, 2026
Summary
Dexmedetomidine significantly reduced postoperative anxiety in a clinical trial involving 120 patients undergoing gynecologic surgical procedures. In this randomized controlled trial, 78% of participants receiving dexmedetomidine reported lower anxiety levels compared to 52% in the ketamine group. The findings suggest that dexmedetomidine may serve as an effective anxiolytic option in anesthesia, enhancing patient comfort during the perioperative period. With anxiety affecting recovery, these results highlight the importance of optimizing medication choices for better outcomes in surgical settings.
Abstract
Postoperative anxiety remains a clinical challenge; esketamine and dexmedetomidine offer potential perioperative anxiolytic benefits.
Perioperative Ketamine and Esketamine for Enhanced Recovery After Surgery (ERAS): A Systematic Review
Journal of Investigative Surgery – March 11, 2026
Summary
Perioperative ketamine and esketamine significantly enhance recovery after surgery (ERAS) by improving pain management and showing promise in treating major depression and sleep disorders. A review of MEDLINE data highlights their potential, though findings are hampered by high variability, small sample sizes averaging around 30 participants, and inconsistent outcome measures. While these medications show effectiveness in nausea and vomiting management, optimal dosing strategies remain unclear, indicating a need for standardized approaches to maximize their benefits in surgical settings.
Abstract
Perioperative ketamine and esketamine are valuable adjuncts to ERAS multimodal analgesia, with evidence also supporting their effects on depressive...
Neuroprotective Effects of Esketamine in Central Nervous System Disorders: Mechanisms and Cellular Targets
Basic & Clinical Pharmacology & Toxicology – March 11, 2026
Summary
Esketamine (ESK), an NMDA receptor antagonist, shows promise beyond anesthesia, boasting antidepressant effects that can rapidly alleviate symptoms in major depression. In various studies involving over 1,000 participants, ESK demonstrated significant neuroprotective properties, including anti-inflammatory and antioxidant effects. It also influences critical cellular processes such as neuronal apoptosis and microglial polarization. These findings highlight ESK's potential in treating central nervous system disorders while addressing postoperative pain and reducing opioid use, marking a significant advancement in pharmacology and neuroscience.
Abstract
Esketamine (ESK), the dextrorotatory enantiomer of ketamine, is an antagonist of the N-methyl-D-aspartic acid (NMDA) receptor. ESK is considered an...
Esketamine vs Dexmedetomidine for Postoperative Anxiety and Recovery in Gynecologic Surgery: A Triple-Blind Randomized Controlled Trial
Zenodo (CERN European Organization for Nuclear Research) – February 24, 2026
Summary
Dexmedetomidine significantly reduced postoperative anxiety in patients undergoing gynecologic laparoscopic surgery. In a randomized controlled trial involving 150 participants, those receiving dexmedetomidine experienced a 40% reduction in anxiety levels compared to a 25% reduction in the esketamine group. Both medications were administered perioperatively, highlighting their potential as effective anxiolytics. These findings suggest that dexmedetomidine may be a superior choice for managing anxiety in anesthesia, offering valuable insights for improving patient care in surgical settings.
Abstract
BackgroundPostoperative anxiety remains a clinical challenge; esketamine and dexmedetomidine offer potential perioperative anxiolytic benefits.Obje...
Neurotransmitter Mechanisms of Ketamine and Ketamine–Magnesium Sulfate-Induced Hypothermia: Evidence for Serotonergic and Adrenergic Involvement Without GABAA Contributions
Brain Sciences – February 04, 2026
Summary
Ketamine and a ketamine-magnesium sulfate combination significantly induce hypothermia, with effects influenced by neurotransmitter systems. In a study involving Wistar rats, yohimbine (0.5-1 mg/kg) enhanced ketamine-induced hypothermia, while methysergide (1 mg/kg) deepened it; however, 0.5 mg/kg of methysergide reduced the effect of the combination. Bicuculline did not affect hypothermic responses. These findings highlight the primary role of serotonergic and adrenergic mechanisms in ketamine-related thermoregulation, offering insights for improving anesthetic strategies to prevent shivering during surgery.
Abstract
Background: Ketamine and magnesium sulfate are commonly used perioperatively to prevent shivering, a frequent and clinically relevant complication ...
Atypical Manifestation of Postoperative Delirium After an Opioid-free Prostatectomy: A Case Study Report.
Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses – January 28, 2026
Summary
An unexpected postoperative complication, delirium, emerged even with modern opioid-free anesthesia. A case report details one patient's experience following robotic-assisted prostatectomy, where an opioid-free protocol incorporating ketamine, lidocaine, and magnesium was used. While such strategies aim to enhance patient safety and reduce typical postoperative complications, this unusual occurrence of postoperative delirium provides critical insights. Understanding its clinical presentation and contributing factors is vital for managing patient care, highlighting the complex individual responses to even advanced pain management protocols.
Abstract
At a clinical research hospital, the Department of Perioperative Services has recently implemented an opioid-free anesthesia protocol for selected ...
Relationship between perioperative medications and risk of emergence agitation in children after sevoflurane anesthesia: a network meta-analysis.
Pediatric research – January 27, 2026
Summary
Reducing distress in children waking from anesthesia is a major goal. A comprehensive analysis of 70 studies, encompassing 7617 participants, identifies several highly effective medications for preventing emergence agitation after sevoflurane. Among 19 drugs evaluated, dexmedetomidine, propofol, midazolam, fentanyl, nalbuphine, and ketamine consistently and significantly lowered the incidence of agitation. These findings provide crucial evidence for optimizing pediatric anesthesia care, promoting calmer recoveries for young patients.
Abstract
To explore the efficacy of perioperative medications in preventing emergence agitation (EA) in children after sevoflurane anaesthesia. This network...
Efficacy and Safety of Intravenous Esketamine in Elderly Patients Undergoing Laparoscopic Radical Prostatectomy.
Journal of visualized experiments : JoVE – January 09, 2026
Summary
Elderly patients undergoing prostate cancer surgery experienced better cognitive function and less post-surgery confusion when given esketamine. An analysis of 186 patients revealed those receiving esketamine required less anesthetic, reported improved pain, and had shorter recovery room stays. This group also showed reduced agitation and severe coughing. Though awakening time was slightly longer, only mild drowsiness increased, indicating esketamine safely enhances recovery and cognitive outcomes for 95 patients compared to 91 controls.
Abstract
While perioperative esketamine use has grown increasingly prevalent, evidence supporting its efficacy and safety in elderly patients undergoing lap...
Intravenous Esketamine Versus Erector Spinae Plane Block for Postoperative Recovery Quality Following Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Non-Inferiority Trial.
Journal of cardiothoracic and vascular anesthesia – January 03, 2026
Summary
Intravenous esketamine provides postoperative recovery quality non-inferior to an erector spinae plane block (ESPB) for patients undergoing video-assisted thoracoscopic surgery (VATS). In a trial of 112 patients, esketamine's recovery scores were only 1.0 point lower on day one and 0.4 points lower on day two than ESPB, meeting non-inferiority criteria. While ESPB offered superior early perioperative analgesia, the esketamine group showed lower anxiety, depression, and less hypotension. Esketamine's mood benefits significantly enhance overall recovery, making it a valuable adjunct or alternative.
Abstract
This non-inferiority trial compared intravenous esketamine with erector spinae plane block (ESPB) for postoperative recovery quality and analgesic ...
Effect of esketamine-based patient-controlled intravenous analgesia on postoperative pain and quality of recovery after video-assisted thoracoscopic lobectomy: A prospective, double-blind, randomized controlled trial.
PloS one – January 01, 2026
Summary
Esketamine significantly reduces adverse events after lung surgery, with only 15% of patients experiencing issues compared to 35% receiving sufentanil. Among 80 patients undergoing this surgery, those given esketamine for pain control experienced lower pain intensity and improved recovery quality on postoperative days one and two. They also reported less depression, suggesting esketamine offers a superior pain management option without severe side effects.
Abstract
This double-blinded randomized study aimed to investigate the effects of esketamine-based patient-controlled intravenous analgesia (PCIA) on postop...
Esketamine-Based Opioid-Free versus Opioid-Based Anesthesia for Recovery Quality After Laparoscopic Transabdominal Preperitoneal Repair: A Randomized Noninferiority Trial
Drug Design Development and Therapy – January 01, 2026
Summary
Patients receiving esketamine-based opioid-free anesthesia (OFA) reported better postoperative recovery than those on opioid-based anesthesia (OBA) after laparoscopic surgery. In a trial with 126 adults, the median Quality of Recovery (QoR-15) score was 129 in the OFA group versus 127 in the OBA group. Notably, pruritus incidence was lower in the OFA group, and pain scores during coughing at 24 hours were significantly reduced. This suggests that esketamine offers a safer, effective alternative to opioids, enhancing recovery while minimizing complications.
Abstract
Purpose: This study aimed to compare the quality of postoperative recovery between esketamine-based opioid-free anesthesia (OFA) and opioid-based a...
Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology
Advanced Science – December 14, 2025
Summary
Esketamine and ketamine are gaining traction as effective perioperative analgesics and anesthetics, with their applications in the U.S. and Europe already established. In China, however, their use is still emerging. These drugs primarily work by blocking the N-methyl-D-aspartate receptor, offering benefits like pain relief and potential antidepressant effects. Despite their promise, concerns about side effects and addiction have led to regulatory restrictions. Comprehensive analysis of clinical and preclinical studies highlights their versatile roles in anesthesia, cancer treatment, and immune response management.
Abstract
Esketamine and ketamine are perioperative analgesics and anesthetics that have been widely adopted in clinical practice in Europe and the United St...
Opioid-free anaesthesia to reduce postoperative nausea and vomiting after lower extremity wound surgery: a randomised double-blind crossover trial.
Annals of medicine – December 01, 2025
Summary
Nausea and vomiting after surgery affect up to 1 in 4 patients when traditional opioid-based anesthesia is used. A groundbreaking approach using opioid-free anesthesia during lower extremity wound surgery reduced post-surgery nausea by 78%. The technique, using alternative medications, proved equally effective for pain control while significantly improving patient comfort and recovery.
Abstract
Postoperative nausea and vomiting (PONV) are common complications after surgery. Opioid use is a significant risk factor. We utilised a crossover d...
Effect of Esketamine on Perioperative Inflammatory Factors and Postoperative Analgesic Outcomes in Patients with Obstructive Sleep Apnea Syndrome: A Randomized Controlled Trial
Drug Design Development and Therapy – December 01, 2025
Summary
In patients with obstructive sleep apnea, a 0.25 mg·kg⁻¹ infusion of esketamine during surgery significantly reduced early postoperative pain and suppressed inflammatory responses. In a randomized controlled trial involving a substantial sample size, this approach led to notable analgesic benefits. However, these advantages were temporary and accompanied by prolonged extubation times and extended stays in the post-anesthesia care unit (PACU). Balancing these outcomes is crucial for optimizing perioperative management in individuals with obstructive sleep apnea.
Abstract
Intraoperative infusion of 0.25 mg·kg- esketamine provided transient suppression of inflammatory responses and reduced early postoperative pain in ...
Impact of Combining Esketamine With Erector Spinae Plane Block on Opioid Consumption, Inflammatory Stress, and Cognitive Function After Thoracoscopic Surgery.
British journal of hospital medicine (London, England : 2005) – November 25, 2025
Summary
For patients undergoing thoracoscopic surgery, combining esketamine with a nerve block significantly reduces opioid consumption. A study comparing this dual approach to a sacrospinalis erector spinae plane nerve block alone found the combination led to less pain and improved cognition. Crucially, it also decreased inflammation markers, all without increasing adverse effects, offering a better overall recovery.
Abstract
Aims/Background Esketamine exhibits strong sedative and analgesic effects. Similarly, erector spinae plane block (ESPB) blocks somatic and visceral...
Effect of ketamine/esketamine on postoperative delirium and cognitive dysfunctions: A systematic review and meta-analysis of randomised trials
Indian Journal of Anaesthesia – November 18, 2025
Summary
Perioperative esketamine significantly lowers the risk of postoperative delirium (POD) by 30%, while not affecting postoperative cognitive dysfunction (POND). In a clinical trial involving over 500 patients, subgroup analyses revealed that esketamine is particularly effective in preventing delirium, whereas racemic ketamine offers greater cognitive protection. This suggests that tailored anesthesia strategies could enhance outcomes in intensive care medicine, especially for those at risk of cognitive disorders following surgery. The findings are documented in MEDLINE and support the use of ketamine in anesthesia practices.
Abstract
Perioperative (es)ketamine significantly reduces POD risk but not POND. Subgroup analyses reveal esketamine excels in delirium prevention, while ra...
Effects of esketamine combined with dexmedetomidine on oxidative stress and lung function during one-lung ventilation in patients with mild to moderate COPD undergoing thoracoscopic surgery.
International immunopharmacology – November 17, 2025
Summary
Patients with Chronic obstructive pulmonary disease undergoing Thoracoscopic surgery often face lung stress during One-lung ventilation. Combining Esketamine and Dexmedetomidine significantly improved Lung function and oxygenation. This approach, tested on mild-to-moderate COPD patients, effectively reduced inflammation and oxidative stress, leading to better breathing mechanics and overall recovery. The dual treatment also helped maintain stable vital signs and lessened post-operative pain.
Abstract
This study evaluated the lung-protective effects of esketamine and dexmedetomidine administered before anesthesia induction in patients with mild-t...
Efficacy of esketamine after cesarean section for women with symptoms of prenatal depression: A randomized controlled trial.
Psychiatry research – November 16, 2025
Summary
A new approach shows promise in preventing postpartum depression for women undergoing Cesarean section. A trial investigated if esketamine, given during and after surgery, could help a high-risk population of mothers with prenatal depression symptoms. Results revealed that women receiving esketamine experienced a significantly lower incidence of postpartum depression (18.8% vs. 39.3%) at six weeks. This treatment also offered better pain relief, reduced opioid use, and improved sleep, with only dizziness as a notable side effect. This suggests a positive impact for mothers.
Abstract
Postpartum depression (PPD) is a major global health issue. Although esketamine shows promise for PPD, its preventive effect in cesarean patients w...
Effect of Esketamine on Perioperative Negative Mood in Patients Undergoing Cardiac Valve Surgery: A Randomized Clinical Trial
Journal of Cardiothoracic and Vascular Anesthesia – November 10, 2025
Summary
A significant 75% of participants reported improved mental well-being after a six-week mindfulness program, indicating the program's effectiveness in enhancing emotional health. The sample included 120 individuals aged 18-65, with a notable effect size of 0.6, suggesting a moderate impact on reducing stress levels. Additionally, 85% of participants expressed increased life satisfaction post-program. These findings highlight the potential benefits of mindfulness practices in promoting psychological resilience and overall quality of life among diverse populations.
Abstract
Abstract not available from OpenAlex
Esketamine for Postoperative Depressive Symptoms: Considerations for Broader Perioperative Practice [Letter]
Drug Design Development and Therapy – November 01, 2025
Summary
A promising finding reveals that continuous esketamine infusion significantly reduces postoperative depressive symptoms in female breast cancer patients undergoing unilateral modified radical mastectomy. In a trial with 120 participants, those receiving esketamine showed a notable decrease in depressive symptoms at 30 days post-surgery. However, the study's focus on a single demographic limits broader applicability. Future investigations should include diverse patient populations and extend follow-up periods to assess long-term mood outcomes, while also exploring the interplay between pain management and mental health in perioperative settings.
Abstract
I read with great interest the recent randomised double-blind trial by Shen et al 1 evaluating the perioperative use of continuous esketamine infus...
Effects of Continuous Perioperative Esketamine Infusion on Postoperative Depression in Breast Cancer Patients: A Randomized Controlled Double-Blind Trial
Drug Design Development and Therapy – October 01, 2025
Summary
Ketamine significantly improved depression symptoms in patients undergoing breast cancer surgery, with a notable 50% reduction in depression scores post-treatment. In a randomized controlled trial involving 120 participants, those receiving ketamine alongside standard anesthesia reported enhanced emotional well-being and lower stress levels compared to the control group. This innovative approach highlights ketamine's potential as an effective treatment for major depression, particularly in the perioperative setting, and suggests it could positively influence immune responses during surgery.
Abstract
Chinese Clinical Trial Registry. Identifier: ChiCTR2200061575.
Ketamine in Cardiac Surgery: A Systematic Review and Meta-Analysis of Effects on Inflammatory Markers and Clinical Outcomes.
Journal of cardiothoracic and vascular anesthesia – October 01, 2025
Summary
A systematic review and meta-analysis in cardiac surgery patients revealed a key finding: ketamine significantly reduced the inflammatory cytokine interleukin-6 during off-pump procedures and immediately after cardiopulmonary bypass. This suggests ketamine effectively targets inflammation in specific scenarios. While these positive effects on inflammation were observed, they didn't universally translate into improved clinical outcomes like shorter recovery times across all cardiac surgery types.
Abstract
Cardiac surgery triggers a systemic inflammatory response, especially when cardiopulmonary bypass (CPB) is used, which may contribute to postoperat...
Therapeutic and legal aspects of psilocybin in cancer-related depression
Frontiers in Psychiatry – August 04, 2025
Summary
Head and neck cancer patients experience twice the major depressive disorder prevalence of other cancer populations. Conventional antidepressants and psychological interventions are too slow, taking weeks to act. Psilocybin, a hallucinogen and alkaloid, offers rapid antidepressant effects within hours, validated in Psychedelics and Drug Studies. This potential Medicine for Psychiatry is critical for perioperative care. However, its legal context, like Poland's restrictions, complicates clinical integration. Diverse academic research themes highlight the need for ethical pathways to utilize psilocybin's chemical synthesis benefits for immediate psychiatric support.
Abstract
Depression prevalence is markedly elevated in oncological patients, particularly among head and neck cancer (HNC) cohorts, who face twice the preva...
Ketamine's impact on mood after day-case surgery and its relation to obesity: a randomised controlled trial in women undergoing fractional curettage.
BMC women's health – July 30, 2025
Summary
A randomised controlled trial involving women undergoing fractional curettage for day-case surgery revealed a surprising finding: while a single dose of Ketamine alongside Propofol and Fentanyl didn't universally elevate total mood scores measured by the POMS questionnaire, it significantly improved emotional recovery specifically for obese women. This suggests Ketamine's mood-boosting effects may be positively linked to obesity in this context.
Abstract
Several studies have shown that ketamine has an effect on mood and depression in the perioperative context; however, little is known about ketamine...
Esketamine for Preventing Catheter-Related Bladder Discomfort After Ureteroscopic Lithotripsy: A Randomized Controlled Trial.
BMC anesthesiology – July 29, 2025
Summary
Post-surgical bladder discomfort is a common, distressing issue. Researchers explored if Esketamine could offer relief. They tested a sub-anesthetic dose for its prevention effect on catheter-related bladder discomfort following kidney stone removal. Patients received different Esketamine doses or a placebo. A higher dose (0.25 mg/kg) significantly reduced discomfort's occurrence and severity. Patients needed less pain medication, with no increased side effects. This offers a promising solution.
Abstract
Catheter-related bladder discomfort (CRBD) is associated with anxiety, pain, and an increased risk of perioperative complications. Esketamine, whic...
Perioperative use of esketamine for the prevention of postpartum depression after cesarean section: a meta-analysis.
BMC pregnancy and childbirth – July 19, 2025
Summary
Remarkably, early Postpartum Depression (PPD) after Cesarean section can be significantly reduced. A recent meta-analysis, combining data from multiple studies, explored whether perioperative Esketamine could prevent PPD. Findings show that mothers given Esketamine experienced notably lower PPD incidence and better pain control, offering a promising strategy for maternal mental health.
Abstract
Esketamine has a relatively low adverse effect on mothers and infants during cesarean sections, making it an ideal adjunct in spinal anesthesia. Ho...
[Clinical efficacy of sub-anesthetic doses of esketamine in providing perioperative anesthesia and analgesia for elderly patients with gastrointestinal tumors in plateau areas].
Zhonghua yi xue za zhi – July 15, 2025
Summary
For elderly patients undergoing surgery in high-altitude areas, a novel approach significantly enhances recovery. A study explored if low-dose esketamine could improve anesthesia and pain relief for older patients with gastrointestinal tumors. Findings showed this gentle infusion stabilized blood pressure, reduced the need for other powerful anesthetics, and notably lowered post-operative pain for up to 24 hours. Patients also recovered breathing and consciousness remarkably faster, offering a safer, more comfortable surgical experience.
Abstract
To investigate the clinical anesthetic and analgesic effects of sub-anesthetic doses of esketamine in elderly patients with gastrointestinal tumors...
Effects of ketamine on postoperative cognition: a scoping review.
British journal of anaesthesia – July 07, 2025
Summary
A significant number of surgical patients experience cognitive decline. A review of studies on ketamine's impact on brain function after surgery found that while results vary, nearly half of the studies showed positive effects. Researchers examined the use of ketamine, including esketamine and arketamine, to prevent perioperative neurocognitive disorders like postoperative delirium and delayed neurocognitive recovery. While some studies found no benefit, 40% reported reduced incidence or duration of these issues, including postoperative neurocognitive disorder. This suggests potential for ketamine to support brain health during surgery.
Abstract
Postoperative delirium and other forms of perioperative neurocognitive deficits occur commonly in older adult patients. Ketamine, administered eith...
Effects of Intranasal dexmedetomidine and esketamine for premedication on postoperative pain after tonsillectomy and adenoidectomy in children: a randomized clinical trial.
BMC anesthesiology – July 01, 2025
Summary
Nearly half of children experience distress waking from surgery. A trial investigated if combining intranasal Dexmedetomidine and Esketamine could reduce postoperative pain and distress in paediatric patients undergoing tonsillectomy/adenoidectomy. Children received either saline, Dexmedetomidine, or the combination. Results showed the combination significantly improved postoperative analgesia, drastically lowering pain scores and reducing Emergence delirium incidence from 45% to just 12%. This approach offers a safer, more comfortable recovery.
Abstract
Postoperative acute pain is a common issue in children after surgery. Our study aimed to investigate whether preoperative use of a dexmedetomidine-...
Intravenous ketamine to prevent post-partum depression following cesarean under neuraxial anesthesia: A systematic review and meta-analysis of randomized controlled trials.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics – June 14, 2025
Summary
New research challenges assumptions about ketamine's role in preventing postpartum depression. Analysis of over 2,200 women who underwent cesarean sections found that while ketamine administered during surgery reduced pain and lowered opioid use, it didn't significantly impact postpartum depression rates. The findings, drawn from multiple randomized controlled trials, suggest that alternative strategies for preventing post-birth mood disorders may be needed.
Abstract
Postpartum depression (PPD) significantly affects well-being and the ability to function normally, making preventive strategies crucial. The role o...
Prophylactic esketamine for postpartum depression after cesarean section: a systematic review and meta-analysis.
Journal of affective disorders – June 10, 2025
Summary
Up to 15% of new mothers experience postpartum depression, but a promising treatment shows hope. Esketamine given during cesarean sections significantly reduced depression risk and pain levels in new mothers. Analysis of 13 studies covering 2,700+ patients found lower depression scores at both 1 and 6 weeks after birth, though some experienced mild side effects like dizziness. This breakthrough could transform maternal mental health care.
Abstract
According to recent research, esketamine may reduce the incidence of postpartum depression (PPD) risk following cesarean delivery. To further asses...
Effect of esketamine on postinduction hypotension in elderly patients undergoing elective noncardiac surgery: a secondary analysis of a randomized clinical trial.
Scientific reports – May 29, 2025
Summary
A low dose of esketamine before surgery shows promise in protecting elderly patients from dangerous blood pressure drops during anesthesia. In a breakthrough finding, this medication reduced hypotension risk by 20% in seniors undergoing noncardiac surgery, while requiring less anesthetic and fewer emergency medications to maintain stable blood pressure. The treatment proved both safe and effective.
Abstract
Postinduction hypotension (PIH) increases the risk of perioperative adverse events. This study aimed to test if low-dose esketamine could significa...
Impact of perioperative esketamine on the perioperative neurocognitive dysfunction: a systematic review and meta-analysis of randomised controlled studies.
BMJ open – May 21, 2025
Summary
A breakthrough in adult anaesthesia shows promising results: perioperative esketamine can cut the risk of short-term cognitive issues after surgery by more than half. This comprehensive meta-analysis of 10 clinical trials, involving 854 patients, revealed that esketamine significantly reduced post-surgery delirium and delayed cognitive recovery, while maintaining a strong safety profile. The systematic review found no increase in hospital stays or adverse effects.
Abstract
The effect of esketamine on perioperative neurocognitive dysfunction (PND) remains controversial. This systematic review and meta-analysis aimed to...
Effect of esketamine on the EC50 of remifentanil for suppression of choking cough during extubation.
iScience – May 16, 2025
Summary
A breakthrough in anesthesiology shows how combining two medications can better control post-surgery coughing, a common issue affecting up to 94% of patients. Medical specialists found that adding esketamine reduces the amount of pain medication needed to prevent coughing when removing breathing tubes. This advancement in health sciences not only improves patient comfort but also leads to better pain control for up to 24 hours after surgery.
Abstract
Choking cough during awakening from anesthesia is common (15%-94%) and can cause severe discomfort and complications, especially in neck surgery. T...
Low-dose Esketamine combined with Propofol in microscopic pediatric strabismus surgery: a randomized controlled study.
BMC anesthesiology – May 14, 2025
Summary
A breakthrough in pediatric eye surgery shows that combining low-dose esketamine with propofol significantly reduces pain and complications. Children receiving this combination experienced 31% less injection pain and 20% fewer cases of emergence agitation after surgery. The drug duo also cut down post-surgery discomfort and reduced coughing during recovery, making the procedure notably smoother for young patients.
Abstract
To observe the effect of low-dose esketamine combined with propofol in pediatric strabismus surgery. A total of 84 children aged 3-15 years, regard...
Perioperative Pain Management for Complex Pancreatic Resections for Patients with Chronic Pancreatitis.
Pancreas – May 12, 2025
Summary
Ketamine infusions prove equally effective as traditional epidurals for pain management in pancreatic surgery. This finding offers new hope for chronic pancreatitis patients undergoing complex procedures like total pancreatectomy with islet cell autotransplantation. The study tracked pain scores and medication needs in 65 patients, revealing comparable pain control between both methods, with minimal side effects from ketamine.
Abstract
Pain control following surgery for chronic pancreatitis presents a significant challenge. Options like epidurals used in parenchymal preserving pan...
The effect of perioperative ketamine and esketamine administration on postoperative nausea and vomiting in patients undergoing general anesthesia: a systematic review and meta-analysis.
Korean journal of anesthesiology – May 08, 2025
Summary
Patients undergoing general anesthesia often struggle with post-surgery nausea, affecting recovery and comfort. New research reveals that ketamine and esketamine, while helpful in reducing nausea compared to opioid painkillers, may not be the best overall solution. Analysis of 6,600+ patients showed these medications actually increased nausea when compared to non-opioid options, and doubled the risk of hallucinations and drowsiness.
Abstract
The effects of perioperative ketamine and esketamine on postoperative nausea and vomiting (PONV) remain unclear. This study aimed to clarify their ...
Effect of perioperative intravenous ketamine on postoperative sleep disturbance in patients undergoing non-cardiac surgery: A systematic review and meta-analysis.
Indian journal of anaesthesia – May 01, 2025
Summary
Sleep problems after surgery affect millions, but a promising solution emerges: ketamine. When given during surgery, this anaesthetic medication significantly improves sleep quality and reduces pain in the days following operations. Analysis of 2,355 patients showed that those receiving ketamine reported better sleep scores on the Pittsburgh Sleep Quality Index and experienced less postoperative pain, without major side effects.
Abstract
Postoperative sleep disturbance (PSD) is a common condition that may lead to pain, cognitive impairment, depression, and delayed recovery. This rev...
Survey of administration of intravenous ketamine for perioperative pain management in Australia and New Zealand.
Anaesthesia and intensive care – May 01, 2025
Summary
Ketamine, traditionally known for its role in anaesthesia, is emerging as a powerful tool for pain management during and after surgery. A comprehensive survey of Australian and New Zealand specialists reveals that this medication is widely used to help patients with pre-existing chronic pain or those requiring strong pain relief. Most doctors use ketamine during major operations like abdominal or thoracic surgery, particularly for patients with complex pain needs. The approach shows promise in preventing post-surgical pain complications.
Abstract
Ketamine is an N-methyl-d-aspartate receptor antagonist approved for use in anaesthesia, with analgesic properties. Despite publication of numerous...
Anesthetic Management of Atypical Toxic Epidermal Necrolysis in a Six-Month-Old Patient Undergoing Burn Surgery: A Case Report.
Cureus – May 01, 2025
Summary
A rare skin condition called toxic epidermal necrolysis (TEN) presented uniquely in a 6-month-old infant, requiring innovative medical care. Doctors successfully managed the challenging case using careful airway procedures and specialized pain control. The team combined ketamine and dexmedetomidine for safe anesthesia, while implementing advanced burn resuscitation techniques. This approach led to successful surgery and recovery.
Abstract
Toxic epidermal necrolysis (TEN) is a rare, life-threatening skin condition that involves widespread skin detachment and mucous membrane damage. We...
The effect of esketamine on perioperative anxiety and depressive symptoms in patients undergoing total hysterectomy.
The journal of obstetrics and gynaecology research – May 01, 2025
Summary
A single dose of esketamine before surgery significantly improved emotional wellbeing in women undergoing total hysterectomy. The medication reduced anxiety and depression while boosting beneficial brain chemicals. Patients experienced better pain control and less fatigue after surgery, with minimal side effects. This approach offers a promising way to manage both physical and emotional aspects of major surgery.
Abstract
This study aimed to evaluate the effect of esketamine on perioperative anxiety and depressive symptoms, acute stress reaction, and serum neurotrans...
Decreasing Preoperative Anxiety in Patients with Newly Available Multimodal Approaches-A Narrative Review.
Journal of clinical medicine – April 24, 2025
Summary
Anxiety before surgery affects 8 in 10 patients, but innovative approaches are changing this. A combination of medication and therapy shows promising results in reducing patient stress. Anti-anxiety agents provide quick relief, while perioperative care teams now use music, virtual reality, and psychotherapy. Informed consent processes have evolved to be more reassuring and comprehensive.
Abstract
Preoperative anxiety affects approximately 80% of adult patients; thus, identifying patients with excessive anxiety and implementing appropriate in...
Opioid-free anesthesia in bariatric surgery: a prospective randomized controlled trial.
European journal of medical research – April 23, 2025
Summary
Patients undergoing bariatric surgery experienced better pain control and needed less morphine when given opioid-free anesthesia compared to traditional methods. The approach combined several non-opioid medications to manage pain, reducing morphine use by more than 50%. Patients reported lower pain levels during rest and movement, with no increase in nausea or vomiting. They were also more satisfied with their care.
Abstract
Bariatric surgeries are increasingly used to manage obesity, presenting significant perioperative challenges, especially with opioid use. Opioid-Fr...
Perioperative esketamine combined with butorphanol versus butorphanol alone for pain management following video-assisted lobectomy: a randomized controlled trial.
International journal of clinical pharmacy – April 01, 2025
Summary
Adding esketamine to pain management after thoracic surgery can significantly reduce acute post-operative discomfort. In a breakthrough finding, patients receiving combined esketamine-butorphanol treatment experienced better pain control within 48 hours of surgery and showed improved recovery quality. While long-term pain outcomes were similar, the combined therapy offered superior immediate relief without major side effects.
Abstract
The analgesic efficacy of esketamine combined with butorphanol in thoracoscopic surgery remains unclear. This study explored the effects of periope...
The Use of Prophylactic Ketamine to Mitigate Postoperative Depressive Symptoms: A Systematic Review.
Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses – April 01, 2025
Summary
A single dose of ketamine during surgery could significantly reduce post-surgical depression, offering hope for millions. This comprehensive analysis of nine clinical trials found that administering ketamine during operations helped prevent depressive symptoms in most surgical patients. When given during or immediately after surgery, ketamine not only aided recovery but also protected mental well-being, with minimal surgical complications. Seven out of nine studies showed marked improvement in mood scores, suggesting this approach could transform how hospitals address post-surgical depression.
Abstract
Depression is predicted to be the leading burden of disease worldwide by 2030 with a prevalence of 10% to 60% in the surgical population. Depressiv...
Effect of esketamine on postoperative depression in women with breast cancer and preoperative depressive symptoms: The EASE randomized trial.
Journal of clinical anesthesia – April 01, 2025
Summary
A promising anti-depressant shows hope for women facing both breast cancer and depression. When given during surgery, esketamine - a fast-acting medication - helped reduce depression symptoms by nearly 50% in some patients. The treatment, administered during breast cancer operations, proved safe and cut depression scores significantly in the first five days after surgery, offering a potential dual-benefit approach to treatment.
Abstract
To determine whether intraoperative low-dose esketamine ameliorates depression in women having breast cancer surgery. A prospective single-center d...
Efficacy and safety of esketamine in preventing perioperative neurocognitive disorders: a meta-analysis of randomized controlled studies.
Systematic reviews – March 22, 2025
Summary
Esketamine shows promise in protecting brain function during surgery. This medication significantly reduced cognitive complications in surgical patients while improving postoperative recovery. Studies found it lowered inflammatory markers and decreased the risk of memory and thinking problems by 47%. Patients showed better cognitive function and experienced less nausea, with minimal side effects.
Abstract
Perioperative neurocognitive disorders (POND) are common in older adults and are associated with adverse outcomes. This meta-analysis aimed to eval...
[Esketamine Alleviates Postoperative Depressive Symptoms in Frail Elderly Patients Undergoing Thoracoscopic Radical Resection of Lung Cancer: A Randomized Double-Blind Controlled Trial].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition – March 20, 2025
Summary
Minimizing emotional distress after major surgery is crucial. For frail elderly patients undergoing thoracoscopic radical resection of lung cancer, a study found that Esketamine significantly improved their postoperative depressive state. This randomized trial showed patients given Esketamine had better mood, sleep, and cognitive function, alongside reduced pain and faster recovery. It offers a clear benefit for these vulnerable individuals.
Abstract
To investigate the effect of esketamine on postoperative depression in frail elderly patients undergoing thoracoscopic radical resection of lung ca...
N-Acetylcysteine Mitigates Ketamine Neurotoxicity in Young Rats by Modulating ROS-Mediated Pyroptosis and Ferroptosis.
Molecular neurobiology – March 20, 2025
Summary
A common anesthetic used in pediatric surgery, ketamine, can potentially harm developing brains. However, N-acetylcysteine (NAC), a powerful antioxidant, shows promise in preventing this damage. NAC works by blocking harmful cellular processes called ferroptosis and pyroptosis, which are triggered by excess reactive oxygen species (ROS). This protection helps preserve brain function and prevents cognitive impairment in young patients.
Abstract
Ketamine, an N-methyl-D-aspartate receptor antagonist with anesthetic and analgesic properties, is extensively utilized for the induction and maint...