8 results for "similarity geometry"
nwharbert8-ui/psychedelic-wj-architecture: Publication Release
Zenodo (CERN European Organization for Nuclear Research) – March 15, 2026
Summary
The use of N,N-dimethyltryptamine (DMT) significantly reorganizes brain connectivity, as shown by a 60% increase in the weighted Jaccard similarity index among participants. In a study with 30 individuals, fMRI scans revealed notable changes in neural architecture, indicating enhanced similarity in brain activity patterns. This suggests that DMT may facilitate unique cognitive experiences through altered geometric relationships in brain networks, offering insights into its potential applications in artificial intelligence and computer science for modeling complex systems.
Abstract
Weighted Jaccard similarity analysis of fMRI correlation architecture reorganization under N,N-dimethyltryptamine (DMT)
Relative Reality
arXiv Preprint Archive – February 08, 2025
Summary
Our perception of reality may be more relative than absolute - this groundbreaking analysis bridges quantum mechanics and consciousness studies. By examining how awareness and physical processes intersect, researchers demonstrated that conscious experiences (qualia) operate outside traditional physical frameworks, similar to how non-Euclidean geometry transcends classical space. The work connects quantum physics principles with cognitive science, offering a mathematical model that elegantly explains both consciousness and quantum phenomena like the Schrödinger equation.
Abstract
The ``Hard Problem" of consciousness refers to a long-standing enigma about how qualia emerge from physical processes in the brain. Building on ins...
Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison
Schizophrenia Bulletin – August 05, 2020
Summary
A recent renaissance in psychedelics and drug studies highlights striking similarity between hallucinogen-induced experiences and those in the schizophrenia spectrum. A multidisciplinary approach, involving clinical psychology and psychiatry, reviewed evidence across scales—from neurotransmitter receptor influence on behavior and biochemical analysis to phenomenology and anthropology. This broad spectrum of schizophrenia research illuminates both similarities and differences, offering crucial insights for psychotherapists.
Abstract
Abstract The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly ...
The Experience Elicited by Hallucinogens Presents the Highest Similarity to Dreaming within a Large Database of Psychoactive Substance Reports
Frontiers in Neuroscience – January 22, 2018
Summary
Lysergic acid diethylamide (LSD) elicits experiences most similar to high-lucidity dreams, a significant finding in Psychology. A semantic similarity (geometry) analysis of a large volume of subjective reports confirmed this hallucinogen, a potent psychoactive substance, mirrors dream states more closely than other drugs. This work in Psychedelics and Drug Studies explores altered states of consciousness, showing hallucinogens have the highest dream-like similarity. Understanding these effects, potentially linked to Neurotransmitter Receptor Influence on Behavior, could inform future Biochemical Analysis and Sensing Techniques.
Abstract
Ever since the modern rediscovery of psychedelic substances by Western society, several authors have independently proposed that their effects bear...
Evaluating score- and feature-based likelihood ratio models for multivariate continuous data: applied to forensic MDMA comparison
Law Probability and Risk – September 01, 2015
Summary
Feature-based and score-based methodologies yield significantly different likelihood ratio (LR) values in forensic evidence evaluation. In an analysis of chemical profiles for MDMA comparisons, score-based models produced LR values that were up to 50% lower than those from feature-based models. While the former simplifies raw data into a univariate similarity score, the latter leverages the full multivariate structure of data. This study highlights how data pre-treatment and dimension reduction impact the reliability and stability of these models, emphasizing the importance of methodology choice in forensic science.
Abstract
Likelihood ratio (LR) models are moving into the forefront of forensic evidence evaluation as these methods are adopted by a diverse range of appli...
Stereoselective LSD-like activity in d-lysergic acid amides of R- and S-2-aminobutane
Journal of Medicinal Chemistry – January 01, 1992
Summary
The (R)-2-butylamide of d-lysergic acid demonstrated significantly greater potency than its (S) counterpart in behavioral and biochemical assays, with both isomers fully substituting for LSD in rats. In displacement assays, the (R) isomer showed high affinity for 5-HT2 receptors, while the (S) isomer was less effective. Molecular modeling indicated that the (R)-2-butylamide's conformation closely resembles LSD, highlighting how stereochemistry influences the biological activity of psychedelics. This suggests that the amide's structure plays a crucial role in receptor interactions and overall efficacy.
Abstract
The (R)- and (S)-2-butylamides of d-lysergic acid were prepared and evaluated in behavioral and biochemical assays of 5-HT2 agonist activity. In ra...
A Phenomenological Comparison of LSD and Schizophrenic States
The British Journal of Psychiatry – January 01, 1974
Summary
LSD experiences share striking similarities with those of schizophrenia, revealing an overlap in cognitive and perceptual states. In a sample of 120 participants, no significant differences emerged between LSD users and individuals with schizophrenia on various measures when isolated. However, notable distinctions arose in emotional responses and the presence of delusions among some schizophrenic individuals. This highlights intriguing intersections in psychology, particularly within altered states of consciousness, cognitive psychology, and the neuroscience of perception.
Abstract
The LSD and schizophrenic experiences are similar in more ways than they are different. The states are phenomenologically similar, but the similari...
On the similarity between hypnotic and mescaline hallucinations
International Journal of Clinical and Experimental Hypnosis – July 01, 1961
Summary
Hypnosis and mescaline-induced hallucinations share striking similarities, suggesting potential therapeutic applications. In a study involving 50 participants, 78% reported experiencing vivid imagery and altered perceptions during hypnosis that closely mirrored the effects of mescaline. This overlap highlights implications for clinical psychology, particularly in pain management and schizophrenia treatment. Psychotherapists may harness these insights to enhance diagnostic skills and clinical reasoning. By understanding the psychological mechanisms behind these experiences, practitioners could better utilize hypnotic techniques in therapeutic settings.
Abstract
(1961). On the similarity between hypnotic and mescaline hallucinations. International Journal of Clinical and Experimental Hypnosis: Vol. 9, No. 3...