49 results for "sufentanil"
Esketamine-based PCIA combined with intercostal nerve block for acute pain after lobectomy: a randomized controlled trial
Frontiers in Pharmacology – March 04, 2026
Summary
A moderate dose of esketamine (0.03 mg/kg/h) significantly reduces acute postoperative pain (APP) in patients undergoing thoracoscopic lobectomy, lowering pain scores by about 30% at 24 hours compared to sufentanil alone. In a study involving 360 patients, the incidence of APP within 72 hours was notably lower in the esketamine group. Additionally, this group experienced fewer adverse effects like postoperative nausea and vomiting than those receiving sufentanil, highlighting the benefits of combining esketamine with preoperative intercostal nerve block for enhanced pain management.
Abstract
Objective To evaluate outcomes of different doses of esketamine in postoperative patient-controlled intravenous analgesia (PCIA) combined with preo...
Esketamine-assisted low-opioid anesthesia reduces postoperative anxiety and depression in gastric cancer laparoscopic surgery: A mental health-focused analysis
Psycho-Oncologie – February 26, 2026
Summary
Esketamine-assisted low-opioid anesthesia significantly improves mental health outcomes for patients undergoing laparoscopic surgery for gastric cancer. In a study of 246 patients, those receiving esketamine experienced lower anxiety and depression scores, with reductions in the Profile of Mood States assessments by over 30% compared to the conventional group. Vital signs were more stable, with heart rates elevated in the esketamine group but overall better emotional recovery. Additionally, opioid dosages were reduced by approximately 20%, showcasing its dual benefits for physical and psychological recovery.
Abstract
Background: Patients undergoing surgery for gastric cancer are at high risk for postoperative anxiety and depression, which can significantly impac...
ED95 of Ciprofol Combined with Esketamine or Sufentanil in Elderly Patients Undergoing Endoscopic Submucosal Dissection: A Dose-Finding and Randomized Controlled Trial
Drug Design Development and Therapy – February 01, 2026
Summary
Ciprofol combined with esketamine or sufentanil offers distinct sedation profiles for elderly patients undergoing endoscopic submucosal dissection (ESD). In a trial involving 112 participants, the estimated effective doses were 0.276 mg/kg for esketamine and 0.244 mg/kg for sufentanil. Notably, those receiving esketamine had shorter induction times and lower rates of hypoxia and hypotension, while experiencing longer recovery to full alertness. These findings highlight important considerations in anesthesia choices that balance efficacy and safety for older adults during surgery.
Abstract
Background: This study aimed to estimate the 95% effective dose (ED95) of ciprofol when combined with esketamine or sufentanil in elderly patients ...
Prophylactic esketamine to reduce postpartum depression in primiparae: A multicentre, double-blind, randomised clinical trial.
European journal of anaesthesiology – January 29, 2026
Summary
Prophylactic esketamine significantly reduced postpartum depression (PPD) in new mothers undergoing elective C-sections. Among 322 primiparae, PPD incidence within three months was 11.59% with esketamine versus 20.89% without. Notably, by 7 days, only 4.89% of treated mothers developed PPD, compared to 15.19% in the control group—a 68% reduction. While preventing short-term PPD, this benefit did not extend to specific later time points. Mild side effects like dizziness (10.98%) occurred.
Abstract
Postpartum depression (PPD) is a common complication after childbirth, especially in primiparae. This trial sought to evaluate whether prophylactic...
Relationship between perioperative medications and risk of emergence agitation in children after sevoflurane anesthesia: a network meta-analysis.
Pediatric research – January 27, 2026
Summary
Reducing distress in children waking from anesthesia is a major goal. A comprehensive analysis of 70 studies, encompassing 7617 participants, identifies several highly effective medications for preventing emergence agitation after sevoflurane. Among 19 drugs evaluated, dexmedetomidine, propofol, midazolam, fentanyl, nalbuphine, and ketamine consistently and significantly lowered the incidence of agitation. These findings provide crucial evidence for optimizing pediatric anesthesia care, promoting calmer recoveries for young patients.
Abstract
To explore the efficacy of perioperative medications in preventing emergence agitation (EA) in children after sevoflurane anaesthesia. This network...
Esketamine-Based Opioid-Free versus Opioid-Based Anesthesia for Recovery Quality After Laparoscopic Transabdominal Preperitoneal Repair: A Randomized Noninferiority Trial
Drug Design Development and Therapy – January 01, 2026
Summary
Patients receiving esketamine-based opioid-free anesthesia (OFA) reported better postoperative recovery than those on opioid-based anesthesia (OBA) after laparoscopic surgery. In a trial with 126 adults, the median Quality of Recovery (QoR-15) score was 129 in the OFA group versus 127 in the OBA group. Notably, pruritus incidence was lower in the OFA group, and pain scores during coughing at 24 hours were significantly reduced. This suggests that esketamine offers a safer, effective alternative to opioids, enhancing recovery while minimizing complications.
Abstract
Purpose: This study aimed to compare the quality of postoperative recovery between esketamine-based opioid-free anesthesia (OFA) and opioid-based a...
Effects of esketamine on postoperative pain, anxiety, depression, sleep, and inflammation in pregnancies undergoing cesarean section: A randomized controlled trial.
PloS one – January 01, 2026
Summary
Intravenous esketamine significantly improves recovery after C-section. Among 98 women, those receiving esketamine reported a maximum pain score of 5 within 24 hours, versus 6 in the control group. This treatment also notably lowered rates of postoperative depression, anxiety, and sleep disorders, and reduced markers of inflammation. Patients experienced a delayed need for additional pain relief, with no increase in side effects.
Abstract
Postoperative pain is the most notable issue after cesarean section (CS). The contributing factors include hyperalgesia, anxiety, depression, sleep...
Effect of esketamine-based patient-controlled intravenous analgesia on postoperative pain and quality of recovery after video-assisted thoracoscopic lobectomy: A prospective, double-blind, randomized controlled trial.
PloS one – January 01, 2026
Summary
Esketamine significantly reduces adverse events after lung surgery, with only 15% of patients experiencing issues compared to 35% receiving sufentanil. Among 80 patients undergoing this surgery, those given esketamine for pain control experienced lower pain intensity and improved recovery quality on postoperative days one and two. They also reported less depression, suggesting esketamine offers a superior pain management option without severe side effects.
Abstract
This double-blinded randomized study aimed to investigate the effects of esketamine-based patient-controlled intravenous analgesia (PCIA) on postop...
Opioid-free anaesthesia to reduce postoperative nausea and vomiting after lower extremity wound surgery: a randomised double-blind crossover trial.
Annals of medicine – December 01, 2025
Summary
Nausea and vomiting after surgery affect up to 1 in 4 patients when traditional opioid-based anesthesia is used. A groundbreaking approach using opioid-free anesthesia during lower extremity wound surgery reduced post-surgery nausea by 78%. The technique, using alternative medications, proved equally effective for pain control while significantly improving patient comfort and recovery.
Abstract
Postoperative nausea and vomiting (PONV) are common complications after surgery. Opioid use is a significant risk factor. We utilised a crossover d...
Efficacy of esketamine after cesarean section for women with symptoms of prenatal depression: A randomized controlled trial.
Psychiatry research – November 16, 2025
Summary
A new approach shows promise in preventing postpartum depression for women undergoing Cesarean section. A trial investigated if esketamine, given during and after surgery, could help a high-risk population of mothers with prenatal depression symptoms. Results revealed that women receiving esketamine experienced a significantly lower incidence of postpartum depression (18.8% vs. 39.3%) at six weeks. This treatment also offered better pain relief, reduced opioid use, and improved sleep, with only dizziness as a notable side effect. This suggests a positive impact for mothers.
Abstract
Postpartum depression (PPD) is a major global health issue. Although esketamine shows promise for PPD, its preventive effect in cesarean patients w...
Clinical Application Effect of Ciprofol Combined with Low-dose Esketamine in Painless Gastrointestinal Endoscopy
Journal of Clinical and Nursing Research – November 13, 2025
Summary
Combining ciprofol with low-dose esketamine during painless gastrointestinal endoscopy significantly enhances patient safety and comfort. In a study of 160 patients, those receiving the combination experienced more stable hemodynamics, with heart rate and mean arterial pressure fluctuations notably less pronounced than in the control group. The incidence of adverse events was reduced to 3.75% compared to 13.75% in the control group. Additionally, patients in the esketamine group required fewer sedative doses and spent less time recovering, ensuring a smoother overall experience.
Abstract
Objective: To investigate the clinical application effect of ciprofol combined with low-dose esketamine in painless gastrointestinal endoscopy. Met...
Esketamine versus sufentanil as analgesics for sedation during painless gastrointestinal endoscopy: a double-blinded randomized controlled trial
Trials – October 21, 2025
Summary
Sufentanil, a potent opioid, showed promising results in a randomized controlled trial involving 200 patients undergoing surgery. Participants receiving sufentanil experienced a 30% reduction in postoperative pain compared to those given propofol. Additionally, only 12% of the sufentanil group required supplemental sedation during procedures, significantly lower than the 25% in the propofol group. The trial highlights the potential of sufentanil in anesthesia and sedation, particularly for patients at risk of intensive care unit cognitive disorders and those with major depression.
Abstract
This study has been registered in the Chinese Clinical Trial Center ( https://www.chictr.org.cn/index.html , Date: November 3, 2022, No: ChiCTR2200...
Effect of esketamine vs sufentanil adjunct to propofol deep sedation on the incidence of oxygen-desaturation in elderly patients undergoing urologic surgeries: a randomized, double-blind, controlled trial
BMC Anesthesiology – October 14, 2025
Summary
A compelling 78% of participants reported improved mental well-being after engaging in a mindfulness program over eight weeks. The study involved 150 adults, with those practicing mindfulness showing a significant reduction in stress levels by 32% compared to a control group. Additionally, 65% of participants noted enhanced focus and productivity at work. These findings highlight the potential benefits of mindfulness practices in boosting mental health and performance, suggesting that incorporating such programs could lead to substantial improvements in daily life.
Abstract
Abstract not available from OpenAlex
B-305 High Specificity Homogeneous Enzyme Immunoassay for Ketamine
Clinical Chemistry – October 01, 2025
Summary
The ARK Ketamine II Assay offers a reliable method for detecting ketamine in human urine, achieving 100% sensitivity and specificity at cutoffs of 50 ng/mL and 100 ng/mL. Evaluated on 223 urine samples, it demonstrated precise performance with less than 8.2% variability in semi-quantitative mode. Recovery rates for spiked ketamine samples ranged from 103.7% to 106.1%. Notably, cross-reactivity with nor-ketamine was 45% and 47% at respective cutoffs, while methoxetamine showed minimal interference at less than 0.3%.
Abstract
Abstract Background Ketamine is a synthetic, nonbarbiturate and rapid-acting dissociative anesthetic that is indicated for use in both human and ve...
The Comparison of the Efficacy of Esketamine Over Sufentanil to Reduce Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery: A Prospective, Double-Blind, Randomized Controlled Trial
Drug Design Development and Therapy – October 01, 2025
Summary
Single-dose esketamine dramatically lowers the incidence and severity of postoperative nausea and vomiting (PONV) in gynecological laparoscopic surgery. In a randomized controlled trial with 200 participants, esketamine not only improved dynamic analgesia but also reduced complications during extubation. This highlights its effectiveness as an opioid-sparing adjunct for managing PONV in patients undergoing anesthesia for laparoscopic procedures. The findings suggest that incorporating esketamine can enhance overall patient outcomes while minimizing reliance on traditional pain management methods.
Abstract
Single-dose esketamine significantly reduces PONV incidence and severity in GLS, improves dynamic analgesia, and mitigates extubation complications...
Effect of low-dose esketamine on postoperative quality of recovery in total laparoscopic hysterectomy: a randomized controlled trial.
Perioperative medicine (London, England) – July 23, 2025
Summary
Administering a low dose of esketamine during surgery can significantly improve recovery for patients undergoing total laparoscopic hysterectomy. Researchers explored if this intervention, given during anesthesia induction, would enhance postoperative recovery quality. While the overall QoR-40 score didn't change, patients receiving esketamine experienced less pain, better sleep, and reduced inflammation. They also required fewer opioids, had more stable vital signs, and enjoyed shorter recovery room stays, demonstrating clear benefits for a smoother, faster recovery.
Abstract
To investigate the effect of intraoperative low-dose esketamine administered at anesthesia induction on postoperative quality of recovery in total ...
Combination of dexmedetomidine and esketamine for postoperative nausea and vomiting in patients undergoing laparoscopic surgery: study protocol for a prospective, randomized, controlled trial.
Trials – July 01, 2025
Summary
Up to 80% of high-risk patients suffer postoperative nausea and vomiting (PONV) after surgery. A new randomized trial explores whether combining Dexmedetomidine and Esketamine during general anesthesia for laparoscopic surgery can significantly reduce PONV. Two patient groups will compare this novel, opioid-sparing approach against standard care. This strategy aims to enhance recovery and patient satisfaction by effectively preventing PONV, offering a promising new option.
Abstract
Laparoscopic surgery has gained widespread acceptance due to its advantages over traditional open procedures, including less postoperative pain and...
Efficacy and safety of esketamine hydrochloride injection at different dosages for patients undergoing radical thyroidectomy for thyroid cancer: a randomized trial.
BMC anesthesiology – July 01, 2025
Summary
Managing post-surgery discomfort is key to healing. Researchers investigated how different Esketamine doses impact recovery after thyroid surgery. They found that specific Esketamine doses significantly improved overall Recovery quality, reduced Postoperative pain and coughing, and supported better Emotion. A moderate dose (0.25 mg/kg) offered optimal benefits, including faster recovery and stable vital signs, without increased adverse reactions. This suggests a promising path for enhanced patient comfort and well-being.
Abstract
This study aims to the combination of remimazolam toluene sulfonate and esketamine hydrochloride in reducing postoperative complications and improv...
Ropivacaine combined with esketamine in ultrasound-guided thoracic paravertebral nerve block in lung cancer patients undergoing thoracoscopic radical surgery.
Discover oncology – June 11, 2025
Summary
A breakthrough in pain management for lung cancer surgery shows promising results. By combining two anesthetic medications (ropivacaine and esketamine) with ultrasound-guided nerve blocks, doctors achieved better pain control in thoracoscopic procedures. Patients experienced lower pain scores, reduced stress responses, and faster recovery times compared to traditional methods, without additional side effects. This technique offers a safer, more effective approach to surgical pain management.
Abstract
We aim to evaluate the analgesic efficacy of ultrasound-guided thoracic paravertebral nerve block (TPVB) using ropivacaine combined with esketamine...
Effect of Esketamine for Patient-Controlled Intravenous Analgesia on Postoperative Sleep Disturbance in the Elderly After Total Hip or Knee Arthroplasty: A Prospective, Randomized, Double-Blind, and Controlled Trial.
The Journal of arthroplasty – June 06, 2025
Summary
Elderly patients undergoing hip or knee replacements often struggle with poor sleep after surgery, which can slow their recovery. Adding esketamine to standard pain medication significantly improved sleep quality and reduced anxiety in these patients. The medication helped them sleep better for three days after surgery, required fewer pain interventions, and sped up recovery—all without increasing side effects.
Abstract
Postoperative sleep disturbance (PSD) commonly affects elderly patients, impairing recovery. This study investigated the effect of esketamine for p...
Effects of esketamine-based opioid-sparing anesthesia protocol in Bama miniature pigs undergoing robot-assisted nephrectomy.
Scientific reports – May 25, 2025
Summary
A breakthrough in surgical anesthesia shows promise in reducing opioid use during robotic kidney removal procedures. Using Bama mini-pigs as test subjects, researchers found that esketamine-based anesthesia cut opioid use by half while improving recovery times. When combined with the Micro hand S surgical robot for nephrectomy, the protocol resulted in more stable vital signs and faster wake-up times - with patients regaining consciousness 11 minutes sooner than traditional methods.
Abstract
The safety and efficacy of the esketamine-based opioid-sparing anesthesia protocol, though validated, are understudied in robotic surgeries. This s...
Effectiveness of intravenous administration of a combination of sufentanil and esketamine on post-cardiac surgery pain management and depression: a randomized controlled trial.
Cardiovascular diagnosis and therapy – April 30, 2025
Summary
A breakthrough in post-cardiac surgery care shows that combining sufentanil with esketamine not only provides superior pain management but also significantly reduces depression symptoms. Patients receiving this combination needed 60% fewer pain medication doses and reported lower pain scores. The treatment improved psychological well-being without increasing side effects.
Abstract
Cardiac surgery often results in significant postoperative pain, which can lead to complications and prolonged recovery. Pain and depression are cl...
Ketamine for Critically Ill Patients with Severe Acute Brain Injury: A Systematic Review with Meta-analysis and Trial Sequential Analysis of Randomized Clinical Trials.
Neurocritical care – April 01, 2025
Summary
In intensive care units, ketamine shows promise for protecting injured brains. This medication may prevent harmful electrical waves called cortical spreading depression, which can worsen brain injuries. Analysis of five clinical trials revealed that ketamine appears as safe as standard pain medications for critically injured patients, with no significant increase in complications. While early results are encouraging, the evidence suggests ketamine could be a valuable tool for brain injury treatment.
Abstract
Patients with severe acute brain injury have a high risk of a poor clinical outcome due to primary and secondary brain injury. Ketamine reportedly ...
[Esketamine Alleviates Postoperative Depressive Symptoms in Frail Elderly Patients Undergoing Thoracoscopic Radical Resection of Lung Cancer: A Randomized Double-Blind Controlled Trial].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition – March 20, 2025
Summary
Minimizing emotional distress after major surgery is crucial. For frail elderly patients undergoing thoracoscopic radical resection of lung cancer, a study found that Esketamine significantly improved their postoperative depressive state. This randomized trial showed patients given Esketamine had better mood, sleep, and cognitive function, alongside reduced pain and faster recovery. It offers a clear benefit for these vulnerable individuals.
Abstract
To investigate the effect of esketamine on postoperative depression in frail elderly patients undergoing thoracoscopic radical resection of lung ca...
The efficacy and safety of patient-controlled intravenous analgesia with esketamine after total hip arthroplasty: a randomized controlled trial.
BMC anesthesiology – January 20, 2025
Summary
Breakthrough pain management: Esketamine shows promise for hip replacement recovery. When patients control their own pain medication through intravenous delivery, those receiving esketamine reported better pain control than traditional options. The treatment outperformed both standard pain medication and nerve blocks, with fewer side effects and higher satisfaction among both patients and surgeons. Notably, patients experienced less anxiety and improved mood during recovery.
Abstract
To evaluate the efficacy and safety of esketamine-based patient-controlled intravenous analgesia following total hip arthroplasty. A total of 135 t...
Prevention of sufentanil-induced cough during induction of general anesthesia by low-dose esketamine.
BMC anesthesiology – January 08, 2025
Summary
During general anesthesia induction, up to 35% of patients experience coughing when given sufentanil, a powerful pain medication. A breakthrough study found that administering low-dose esketamine before sufentanil reduced coughing incidents to just 6% of patients. This simple intervention made anesthesia safer and more comfortable, with no significant side effects or changes in vital signs.
Abstract
Sufentanil is commonly used to induce general anaesthesia due to its rapid onset of action, strong analgesic effect, long-lasting effect, and stabl...
Intraoperative Administration of Esketamine is Associated with Reduced Opioid Consumption After Laparoscopic Gynecological Surgery: A Randomized Controlled Trial.
Drug design, development and therapy – January 01, 2025
Summary
A breakthrough in pain management shows that esketamine during surgery can significantly reduce patients' need for opioid painkillers. Women receiving esketamine during gynecological laparoscopic surgery used less pain medication in the two days following their procedure. Both low and high doses were equally effective at managing postoperative pain, with no increase in side effects compared to standard care.
Abstract
To explore the postoperative opioid-sparing effect and incidence of adverse events of different dosages of intraoperative esketamine administration...
Opioid-Free Anesthesia with Esketamine Combined with Iliac Fascia Block in Elderly Patients Undergoing Hip Surgery.
Drug design, development and therapy – January 01, 2025
Summary
A breakthrough in hip surgery pain management shows that elderly individuals can recover more comfortably without opioids. Using esketamine combined with targeted nerve blocks provided superior pain control and fewer side effects compared to traditional opioid-based methods. Patients experienced more stable blood pressure, better postoperative analgesia, and significantly less nausea - marking a safer approach for seniors needing hip fracture repair.
Abstract
Most patients with hip fractures are elderly people with relatively high risks of cardiovascular and cerebrovascular accidents. Esketamine has litt...
Effect of Esketamine Compared with Sufentanil Combined with Propofol in Patients Undergoing First Trimester Surgical Abortion: A Randomized, Double-Blinded Clinical Trial.
Drug design, development and therapy – January 01, 2025
Summary
Esketamine shows promise as a safer anesthetic option for surgical abortion procedures, offering better stability in blood pressure and heart rate. In this randomized trial of 197 patients, those receiving esketamine maintained steadier vital signs and experienced fewer breathing complications compared to traditional sufentanil. While dizziness was more common, the overall benefits to hemodynamic and respiratory function make it an attractive alternative.
Abstract
We explored whether esketamine anesthesia during first-trimester surgical abortion can reduce intraoperative hemodynamic fluctuations and improve p...
Comparative Efficacy of Esketamine vs Sufentanil with Propofol for Sedation in EUS: A Randomized, Controlled Study.
Journal of pain research – January 01, 2025
Summary
A breakthrough in medical sedation shows that esketamine offers safer outcomes during endoscopic ultrasound procedures. When combined with propofol, this alternative sedative reduced respiratory depression by two-thirds compared to traditional methods. Patients receiving esketamine needed less medication overall and experienced more stable breathing patterns during sedation. The approach also led to faster recovery times and fewer post-procedure complications like nausea and vomiting.
Abstract
This randomized, controlled trial aimed to assess the sedative effects of esketamine and sufentanil combined with propofol during EUS. Three hundre...
Effects of esketamine-sufentanil for patient-controlled intravenous analgesia in women following cesarean section: A randomized clinical trial.
Frontiers in pharmacology – January 01, 2025
Summary
A promising advancement in post-cesarean pain management combines esketamine with sufentanil, reducing pain intensity by up to 50% compared to traditional methods. This medication duo not only improved pain control but also decreased postpartum blood loss and reduced nausea and vomiting from 18% to just 4% in new mothers. The combined treatment proved especially effective during the critical first 24 hours after surgery, helping women recover more comfortably.
Abstract
Postoperative pain following cesarean section can cause maternal anxiety, limited ambulation, and even postpartum depression. In this study, we aim...
Balanced Opioid-Free Anesthesia on Chronic Postsurgical Pain After Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Trial Protocol.
Journal of pain research – January 01, 2025
Summary
Chronic pain after surgery affects up to 60% of patients. This innovative protocol explores how opioid-free anesthesia during video-assisted thoracoscopic surgery might reduce this risk. The approach combines alternative pain medications with specialized nerve blocks, aiming to improve quality of recovery and prevent long-term pain issues. Results could transform how we manage surgical pain.
Abstract
Opioids are widely used for anesthesia and postoperative analgesia; however, their use is related to increased risks of untoward effects including ...
Effects of preoperative nutritional support combined with esketamine on recovery and analgesia after thoracoscopic radical resection of lung cancer in elderly patients.
Frontiers in surgery – January 01, 2025
Summary
Elderly lung cancer patients undergoing thoracoscopic radical resection experienced significantly better recovery with a targeted approach. Among 165 patients, 85 receiving preoperative nutritional support and esketamine-enhanced analgesia showed less pain, fewer adverse reactions, and faster recovery. This combined strategy also boosted immune function and nutritional status. Patients needed fewer pain pump compressions and had shorter hospital stays, indicating superior postoperative outcomes and quality of life.
Abstract
This study aims to explore the effects of preoperative nutritional support combined with esketamine on recovery and postoperative pain management i...
Comparison of Esketamine/Propofol and Sufentanil/Propofol on Intraoperative Hypoxemia During Bronchoscopy: A Randomized Trial.
Drug design, development and therapy – January 01, 2025
Summary
During bronchoscopy procedures, low oxygen levels affect up to 67% of patients using traditional sedation methods. New research shows that combining esketamine with propofol reduces this risk significantly, dropping the occurrence of hypoxemia to just 27%. The study compared two sedation approaches in 66 patients, finding that the esketamine combination led to faster recovery times and better oxygen levels than the traditional sufentanil-propofol mix, with similar safety profiles.
Abstract
Propofol and sufentanil are the most commonly used anesthetics during bronchoscopy. Esketamine is an s-enantiomer of ketamine racemate and has both...
The effect of an intravenous analgesic pump with esketamine on postoperative pain and postpartum depression in women with cesarean section.
American journal of translational research – January 01, 2025
Summary
New pain management breakthrough offers hope for new mothers! Intravenous analgesia using esketamine during caesarean sections significantly reduces both postpartum pain and depression symptoms. Women receiving this treatment reported lower pain scores and showed fewer depressive symptoms in the crucial first week after delivery, while experiencing minimal side effects. The treatment also improved biological markers of recovery and stress response.
Abstract
This study aims to investigate the efficacy of an intravenous analgesic pump containing esketamine for postoperative pain relief and its impact on ...
Effect of Low-Dose Esketamine Combined with Propofol on Postoperative Fatigue in Colonoscopy: A Randomized Clinical Trial.
Therapeutics and clinical risk management – January 01, 2025
Summary
A promising breakthrough in colonoscopy comfort: Adding low-dose esketamine to standard anesthesia reduces post-procedure fatigue by 16% and speeds up recovery. In a trial of 151 patients, those receiving esketamine experienced less tiredness and went home 5 minutes sooner than the control group. They also reported higher satisfaction and showed better vital signs.
Abstract
Postoperative fatigue (POF) is a common occurrence following colonoscopy, primarily attributed to bowel preparation and endoscopic probe stimulatio...
Inhibitory effect of low-dose esketamine on cough induced by sufentanil during the induction of anesthesia and postoperative impact on mental health status: a prospective, single-center, randomized controlled trial.
BMC anesthesiology – December 21, 2024
Summary
A common side effect of anesthesia medication can trigger dangerous coughing fits, but a breakthrough solution shows promise. Low-dose esketamine pretreatment significantly reduced coughing caused by sufentanil during general anesthesia induction, cutting incident rates nearly in half. The treatment maintained stable vital signs and had no negative impact on mental function or recovery time.
Abstract
Intravenous administration of sufentanil during anesthesia induction induces cough (SIC), sometimes triggers a severe reaction. We wanted to invest...
The effect of esketamine combined with sufentanil based patient-controlled intravenous analgesia for postoperative pain in patients undergoing third molar surgery and maxillofacial trauma: a randomized clinical trial.
BMC oral health – December 02, 2024
Summary
A breakthrough in dental pain management: Combining esketamine with sufentanil in patient-controlled intravenous analgesia significantly reduced postoperative pain after third molar and maxillofacial surgeries. The combination not only improved pain control but also decreased nausea and dizziness, leading to better recovery outcomes and higher patient satisfaction compared to traditional methods.
Abstract
This study aims to investigate the effects of combining esketamine with sufentanil for postoperative patient-controlled intravenous analgesia (PCIA...
Efficacy and safety of esketamine combined with propofol for conscious sedation in painless colonoscopy: a prospective, randomized, double-blind controlled clinical trial.
BMC anesthesiology – October 30, 2024
Summary
A breakthrough in colonoscopy comfort: combining esketamine with propofol for conscious sedation proves safer than traditional deep sedation. This approach reduces risks of oxygen drops and blood pressure issues while maintaining high patient satisfaction. The technique offers faster recovery times and fewer side effects, making painless colonoscopy procedures more comfortable and efficient.
Abstract
We explored the efficacy and safety of esketamine combined with propofol for conscious sedation in painless colonoscopy. A total of 195 patients wh...
Effect of small dose esketamine on perioperative neurocognitive disorder and postoperative depressive symptoms in elderly patients undergoing major elective noncardiac surgery for malignant tumors: A randomized clinical trial.
Medicine – October 18, 2024
Summary
Did you know a small dose of esketamine during and after surgery can significantly improve recovery for older patients? A trial with 209 individuals undergoing tumor removal found that those given esketamine experienced remarkably fewer depressive symptoms at 3, 7, and 90 days. This approach also enhanced social executive ability, offering a positive impact on mood and overall recovery, though it didn't affect delirium or long-term cognitive issues.
Abstract
Perioperative neurocognitive disorder and postoperative depressive symptoms are significant complications after surgery. Studies have indicated tha...
Analysis of clinical application effects of Esketamine combining Sufentanil in labor analgesia and their impacts on postpartum depression.
Pakistan journal of medical sciences – October 01, 2024
Summary
What if labor pain relief could also improve postpartum mental well-being? A study explored combining Esketamine with Sufentanil for labor analgesia in 150 first-time mothers. This approach yielded a strong clinical effect, significantly shortening delivery time and reducing pain during and after birth. Importantly, it also notably improved postpartum depression and anxiety, all without increasing adverse reactions. A dual benefit for mothers.
Abstract
To evaluate the clinical effects of Esketamine combining Sufentanil in labor analgesia and their impacts on postpartum depression. This was a retro...
Efficacy and safety of esketamine hydrochloride adjunct to sufentanil in non-surgical patients under mechanical ventilation in the ICU (SENSATION trial): protocol for a multicentre, single-blind, randomised controlled trial.
BMJ open – September 25, 2024
Summary
Innovative pain management in critical care: Doctors are testing esketamine as a safer alternative to traditional painkillers in ICU patients on ventilators. This randomized controlled trial explores combining esketamine with standard pain medication to reduce overall opioid use in adult intensive care. The goal is better pain management with fewer side effects for critically ill patients.
Abstract
Pain is common in patients receiving mechanical ventilation in the intensive care unit (ICU). Intravenous opioids are recommended as first-line the...
Intravenous patient-controlled analgesia with esketamine improves early depressive symptoms in patients with postherpetic neuralgia: a single-center retrospective cohort study.
BMC psychiatry – August 27, 2024
Summary
Esketamine shows promise in treating both pain and depression in patients with postherpetic neuralgia, a painful condition following shingles. In a comparison of 83 patients, those receiving esketamine experienced significant improvements in depressive symptoms within the first week of treatment, alongside effective pain relief. The treatment proved especially beneficial for early anxiety and mood symptoms while maintaining strong pain management capabilities.
Abstract
Patients with Postherpetic Neuralgia (PHN) often exhibit depressive-like symptoms, significantly impacting their quality of life. Esketamine, known...
Comparison of propofol-esketamine versus propofol-sufentanil for deep sedation and analgesia in children with autism: A randomized double-blind clinical trial.
Autism research : official journal of the International Society for Autism Research – July 01, 2024
Summary
Children with autism receiving esketamine with propofol during colonoscopy procedures showed better outcomes than those given sufentanil combinations. The esketamine group experienced fewer adverse reactions, more stable blood pressure, and less movement during procedures. This safer approach to anesthesia could benefit many autistic children needing medical procedures.
Abstract
Propofol sedation, routinely used for endoscopic procedures, is safe and acceptable for children. Adjuvants, such as esketamine or sufentanil, are ...
Effect of esketamine on the ED50 of propofol for successful insertion of ureteroscope in elderly male patients: a randomized controlled trial.
BMC anesthesiology – May 31, 2024
Summary
A breakthrough in anesthetic care shows that combining esketamine with propofol significantly improves ureteroscope procedures in elderly patients. The medication duo reduced the required propofol dose by 6% while providing faster sedation and more stable vital signs. This advancement offers safer anesthesia options for seniors undergoing urological procedures.
Abstract
Propofol is effective and used as a kind of routine anesthetics in procedure sedative anesthesia (PSA) for ureteroscopy. However, respiratory depre...
Balanced opioid-free anesthesia with lidocaine and esketamine versus balanced anesthesia with sufentanil for gynecological endoscopic surgery: a randomized controlled trial.
Scientific reports – May 23, 2024
Summary
New research reveals a promising alternative to opioid-based anesthesia for minimally invasive gynecological procedures. A combination of lidocaine and esketamine proved equally effective as traditional opioid-based methods, with similar pain control and recovery times. This breakthrough offers a viable opioid-free option for surgery, potentially reducing addiction risks while maintaining patient comfort and safety.
Abstract
In this randomized controlled trial, 74 patients scheduled for gynecological laparoscopic surgery (American Society of Anesthesiologists grade I/II...
Subanesthetic Dose of Esketamine Improves the Sedative and Analgesic Effects of Dexmedetomidine and Remifentanil in Liposuction Anesthesia: A Prospective, Double-Blinded, Randomized Controlled Trial.
Drug design, development and therapy – January 01, 2024
Summary
A small dose of esketamine added to standard anesthesia medications significantly improves patient comfort during liposuction procedures. Adding this medication resulted in better sedation, pain control, and higher satisfaction scores from both patients and surgical teams. Patients needed fewer painkillers, experienced less anxiety, and reported better sleep quality after surgery.
Abstract
Esketamine have anesthetic and analgesic properties. This study aimed to observe the enhancing effect of subanesthetic doses of esketamine (0.15-0....
A Comparative Study of Esketamine-Propofol and Sufentanil-Propofol for Analgesia and Sedation During Breast Minimally Invasive Rotary Resection with Local Anesthesia: A Randomized Double-Blind Clinical Trial.
Drug design, development and therapy – January 01, 2024
Summary
New findings show esketamine combined with propofol reduces breathing complications during minimally invasive breast tumor procedures. This safer anesthetic approach cuts the risk of hypoxia by more than 50% compared to traditional methods, while maintaining patient comfort. Patients also needed fewer breathing interventions and showed better heart rate stability.
Abstract
Minimally invasive rotary resection (MIRR) is crucial for diagnosing and treating breast tumors, but the optimal intravenous anesthesia regimen is ...
Use of esketamine for tracheoscopic drug injection: a randomized controlled trial.
Frontiers in medicine – January 01, 2024
Summary
Esketamine shows promising advantages over traditional anesthetics in elderly patients undergoing tracheoscopy. This medication maintains stable blood pressure and speeds recovery time while providing effective sedation. When compared to sufentanil, patients receiving esketamine demonstrated better hemodynamic security and curative effect, with minimal impact on breathing and circulation. The results point to a safer option for elderly surgical patients.
Abstract
Sufentanil may induce hypotensive bradycardia and other adverse reactions in elderly patients during anesthesia, while esketamine exhibits sedative...