Microdosing psilocybin and its effect on creativity: Lessons learned from three double-blind placebo controlled longitudinal trials
Neuropharmacology November 2, 2025 Luisa Prochazkova, Josephine Marschall, Michiel van Elk et al. 2 citations
Microdosing psilocybin from truffles modestly improved the quality of divergent thinking—specifically the ratio of original responses to total responses—in a pooled analysis of three double-blind, placebo-controlled trials with 171 participants. The effect on unadjusted originality was significant only when dosage relative to body weight was considered, and it remained after controlling for dose guess and demographic biases. No effects were found on other measures of divergent thinking or on convergent thinking. The findings underscore the need to account for placebo effects and prior psychedelic experience when evaluating microdosing claims.