Mephedrone and Alcohol Interactions in Humans
Frontiers in Pharmacology January 28, 2020 Esther Papaseit, Clara Pérez-mañá, Elizabeth B. de Sousa Fernandes Perna et al. 27 citations
Combining mephedrone with alcohol amplifies cardiovascular effects and intensifies euphoria and well-being compared to either drug alone, while mephedrone reduces the sedative effects of alcohol. In a double-blind, placebo-controlled trial with 11 male volunteers, the combination increased blood pressure, heart rate, and subjective feelings of euphoria. Mephedrone alone and alcohol alone were also tested. The results suggest that the abuse liability of mephedrone is greater when taken with alcohol, similar to other psychostimulants like amphetamines and MDMA.