Fast-acting approaches for treatment-resistant depression: real-world comparative effectiveness of Intranasal Esketamine versus accelerated rTMS.
Int J Psychiatry Clin Pract March 11, 2026 Michele Prato, Matteo Carminati, Filippo Frizzi et al. 1 citation
In a real-world clinical setting, intranasal esketamine and accelerated repetitive transcranial magnetic stimulation (rTMS) showed comparable effectiveness for treatment-resistant depression. Both treatments led to significant reductions in depressive symptoms, with no statistically significant difference between the two approaches. The findings suggest that either option can be a viable fast-acting intervention for patients who have not responded to prior treatments.