Effects of a dissociative drug on fronto-limbic resting-state functional connectivity in individuals with posttraumatic stress disorder: a randomized controlled pilot study.
Psychopharmacology (Berl) October 23, 2023 Sarah K. Danböck, Or Duek, Ziv Ben-Zion et al. 6 citations
A single dose of a dissociative drug altered resting-state functional connectivity between frontal and limbic brain regions in individuals with posttraumatic stress disorder, suggesting a potential mechanism for its therapeutic effects. The randomized controlled pilot study compared drug versus placebo in a small sample, finding changes in connectivity patterns that may relate to symptom reduction. The authors indicate that these preliminary results warrant further investigation in larger trials.