New Psychoactive Substance 5-MeO-MiPT In vivo Acute Toxicity and Hystotoxicological Study.
Balkan Med J January 1, 2021 Yusuf Ali Altuncı, Melike Aydoğdu, Eda Açıkgöz et al. 10 citations
In mice, a low dose (0.27 mg/kg) of the hallucinogenic tryptamine analog 5-MeO-MiPT did not cause serious histopathological effects on the liver, kidney, or brain. A high dose (2.7 mg/kg) induced apoptotic cell death through caspase activity, with significant increases in Caspase-3 and Caspase-8 positive cells in the liver, kidney, and brain compared to controls. Blood concentrations of 5-MeO-MiPT ranged from 2.7 to 13.4 ng/mL, with higher levels in the liver (15.2-108.3 ng/g) and lower levels in the brain (1.5-40.6 ng/g). The findings suggest that high doses trigger programmed cell death via caspase pathways.