Acute Effects of Methylphenidate, Modafinil, and MDMA on Negative Emotion Processing
The International Journal of Neuropsychopharmacology November 22, 2017 André Schmidt, Felix Müller, Patrick C. Dolder et al. 25 citations
Modafinil, but not methylphenidate or MDMA, increased brain activity in a limbic-cortical-striatal-pallidal-thalamic circuit and the amygdala when healthy subjects viewed fearful faces. Activation in frontal brain regions correlated with increased feelings of fearfulness and depressiveness after modafinil. Despite modafinil's cognitive enhancement effects, potential adverse effects on emotion processing should be considered.