Long-Lasting Antidepressant Action of Ketamine, but Not Glycogen Synthase Kinase-3 Inhibitor SB216763, in the Chronic Mild Stress Model of Mice
PLoS ONE February 4, 2013 Xiancang Ma, Yonghui Dang, Min Jia et al. 115 citations
A single dose of the NMDA receptor antagonist ketamine, but not the GSK-3 inhibitor SB216763, produced long-lasting antidepressant effects in a mouse model of chronic mild stress (CMS). In CMS mice, ketamine reversed the drop in sucrose intake and reduced immobility in the tail suspension and forced swimming tests, effects that persisted for 8 days after a single dose. The GSK-3 inhibitor did not produce these effects. Ketamine also reduced immobility in non-stressed control mice. These results suggest that ketamine's rapid and sustained antidepressant action may not depend on GSK-3 inhibition.