A Review of Synthetic Access to Therapeutic Compounds Extracted from Psilocybe.
Pharmaceuticals (Basel, Switzerland) December 28, 2022 Raphaël Serreau, Ammar Amirouche, Amine Benyamina et al. 13 citations
Psychedelic compounds found in Psilocybe mushrooms are being studied for treating central nervous system disorders, but obtaining enough pure material from fungi for research is challenging. This review examines synthetic chemistry methods to produce these molecules, covering classic historical syntheses, modern metal-catalyzed coupling reactions, and biocatalytic approaches. The authors note that alternative synthetic routes will likely be needed as therapeutic interest in these compounds grows.