Natália Bezerra Mota

Department of Psychiatry and Forensic Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

2 papers in the library · 28 citations · publishing 2022-2023

Papers

Low-dose LSD and the stream of thought: Increased Discontinuity of Mind, Deep Thoughts and abstract flow.

Psychopharmacology June 1, 2022 Isabel Wießner, Marcelo Falchi, Fernanda Palhano-Fontes et al. 22 citations

LSD alters the stream of thought in multiple ways, increasing chaos, meaning, and abstractness at different times after ingestion. In a randomized, double-blind, placebo-controlled crossover study with 24 healthy participants, 50 μg LSD compared to placebo induced facets of mind-wandering labeled 'chaos' (discontinuity of mind, decreased sleepiness and planning), 'meaning' (deep thoughts), and 'sensation' (thoughts about odors and sounds). LSD also increased free association for abstract words, reflecting an 'abstract flow.' Chaos was strongest from 2 to 6 hours after dosing, meaning from 2 to 4 hours, sensation at 2 hours, and abstract flow at 4 hours. The findings suggest a late therapeutic window around 4 hours for psycholytic therapy.

DOI: 10.1007/s00213-021-06006-3 Full text LSD Abstract thinking Forward flow Free association +4

LSD and language: Decreased structural connectivity, increased semantic similarity, changed vocabulary in healthy individuals.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology March 1, 2023 Isabel Wießner, Marcelo Falchi, Dimitri Daldegan-Bueno et al. 6 citations

Low to moderate doses of LSD alter language structure, semantics, and vocabulary over time. In a double-blind, placebo-controlled crossover study, 24 healthy volunteers (age 35±11, 33% women) received 50 μg LSD or placebo. LSD reduced verbosity, lexicon, and connectivity in speech networks from 1.5 to 4 hours, decreased semantic distances between words from 2 to 24 hours, and shifted vocabulary related to grammar, persons, time, space, and biological processes from 1.5 to 24 hours. Simpler, disconnected structure and increased semantic similarity may reflect cognitive impairments, while vocabulary changes may indicate subjective perceptual shifts. Automated language analysis could offer unconstrained insights into psychedelic cognition.

DOI: 10.1016/j.euroneuro.2022.12.013 Full text LSD Cognition Natural language processing Semantics +5