Neural correlates of rapid antidepressant response to ketamine in bipolar disorder
Bipolar Disorders September 18, 2013 Allison C. Nugent, Nancy Diazgranados, Paul J. Carlson et al. 86 citations
In people with bipolar disorder who are depressed, a single ketamine infusion alters brain glucose metabolism in regions linked to mood disorders. Those who improved most showed the largest metabolic increase in the right ventral striatum. Ketamine also lowered metabolism in the left hippocampus compared with placebo. Higher baseline activity in the subgenual anterior cingulate cortex predicted a stronger antidepressant response to ketamine. These metabolic changes may help explain how ketamine works.