Ketamine for treatment resistant depression in individuals with eating disorders: a comparison study
Journal of Eating Disorders December 9, 2025 Elizabeth Wassenaar, Dan V. Blalock, Alan Duffy et al. 1 citation
Adults with eating disorders (EDs) who also have treatment-resistant depression or bipolar disorder improved in depression, anxiety, suicidal ideation, and ED symptoms regardless of whether they received subanesthetic intranasal ketamine. In a matched comparison of 85 patients who received ketamine and 85 who did not, both groups showed significant improvements from admission to discharge on all outcomes, with no significant differences between groups. Ketamine-treated patients had significantly longer lengths of stay. The findings suggest ketamine may be a viable option for this population, but its efficacy for treating EDs with comorbid depression was not superior to standard care in this study.