Prefrontal connectivity alterations and oscillatory dynamics in cannabis use disorder.
Biological psychology July 9, 2026 Nattanon Bunrodchu, Ekkasit Kumarnsit, Wan Khairunizam Wan Ahmad et al.
Long-term cannabis use alters default mode network (DMN) dynamics and cross-frequency interactions in the brain. Resting-state EEG recordings from 23 participants with cannabis use disorder (CUD) and 23 healthy controls showed that delta-high gamma and beta-high gamma coupling in prefrontal regions distinguished CUD participants from controls, especially with eyes open. Frontal-parietal and frontal-temporal coherence was heightened during eye closure in CUD participants. A multilayer perceptron classifier using these multidimensional EEG features successfully differentiated cannabis users from controls, suggesting that altered DMN function and cross-frequency coupling are potential electrophysiological markers of long-term cannabis use.