Chronic cannabis use is associated with alterations in resting-state cerebellar-cortical connectivity.
Psychopharmacology December 12, 2025 Ilenia Salsano, Giorgia Picci, Nathan M Petro et al.
Chronic cannabis use in middle-aged adults (average age 42) is linked to disrupted resting-state functional connectivity between the cerebellum and prefrontal-temporal brain regions. Using whole-brain analysis, adults with chronic cannabis use showed decreased connectivity between the right cerebellar Crus II and several frontal and temporal areas, and between the right cerebellar Crus I and the left pars triangularis, compared to demographically matched non-users. These findings suggest that sustained cannabis use may alter communication between brain regions rich in cannabinoid receptors, even in midlife, though the behavioral impact remains unknown.