Effects of the synthetic cannabinoid 5F-AMB on anxiety and recognition memory in mice.
Psychopharmacology July 1, 2019 Shiho Ito, Satoshi Deyama, Masaki Domoto et al.
The synthetic cannabinoid 5F-AMB, when injected into the brain of mice, reduces anxiety and impairs the acquisition of recognition memory by activating CB1 receptors. Systemic injection severely reduces movement, an effect partially blocked by a CB1 antagonist. Infusion into the medial prefrontal cortex impairs memory acquisition but does not affect anxiety, suggesting other brain regions mediate the anxiolytic effect.