Impaired cognitive performance under psychosocial stress in cannabis-dependent men is associated with attenuated precuneus activity
Journal of Psychiatry and Neuroscience February 26, 2020 Weihua Zhao, Kaeli Zimmermann, Xinqi Zhou et al. 14 citations
Cannabis-dependent men show exaggerated cognitive performance deterioration during psychosocial stress compared to controls, despite reporting similar stress levels and cardiovascular responses. Brain imaging revealed that this performance decline was accompanied by reduced activity in the precuneus and increased connectivity between the precuneus and the superior frontal gyrus during stress exposure. The findings provide first evidence linking chronic cannabis use to altered neural stress processing, specifically deficient recruitment of the precuneus, which may underlie stress-induced cognitive impairments in cannabis users.