Effects of marijuana history on the subjective, psychomotor, and reinforcing effects of nitrous oxide in humans.
Drug and alcohol dependence December 1, 1994 S Yajnik, P Thapar, J L Lichtor et al.
An experiment compared marijuana users and non-users to see if their history with cannabis affected how they responded to nitrous oxide. Participants first sampled both 40% nitrous oxide in oxygen and a placebo (100% oxygen), then chose which to inhale in later sessions. Both groups chose nitrous oxide less than half the time, and the choice patterns did not differ significantly between marijuana users and non-users. However, marijuana users reported stronger subjective effects from nitrous oxide, suggesting a history of marijuana use may intensify some of the drug's subjective experiences.