Marie-Ève Tremblay

Neuroscience Graduate Program, University of Victoria, Victoria, BC, Canada. evetremblay@uvic.ca.

2 papers in the library · 25 citations · publishing 2023-2025

Papers

The Missing Piece? A Case for Microglia's Prominent Role in the Therapeutic Action of Anesthetics, Ketamine, and Psychedelics.

Neurochemical research April 1, 2023 Jared VanderZwaag, Torin Halvorson, Kira Dolhan et al. 25 citations

Microglia, the brain's resident immune cells, are emerging as a key target for new psychiatric drugs. This review examines how psychedelics (psilocybin, LSD), ketamine, and propofol interact with microglia to produce therapeutic effects. The authors detail pathways including sigma-1 receptors, serotonin and GABA signaling, and tryptophan metabolism through which these agents modulate microglial activity and inflammation, likely contributing to their benefits in mood disorders and addiction. The paper also discusses future directions, including implications for aging, glial cell heterogeneity, and advanced research methods.

DOI: 10.1007/s11064-022-03772-0 Full text Depression Ketamine Neuroplasticity Anesthetics +6

Potential molecular pathways and therapeutic implications of rapid-acting antidepressants on myelin biology: a scoping review.

Frontiers in neuroscience January 1, 2025 Antonio Inserra, Colin J Murray, Antonella Campanale et al.

Rapid-acting antidepressants, such as ketamine and serotonergic psychedelics, may affect myelin homeostasis. A systematic review of 41 studies (12 in humans, 21 in animals, 7 in vitro, and 1 computational) found that these drugs modulate myelination in a dose- and exposure-dependent manner: therapeutic doses generally promote myelin integrity and oligodendrocyte maturation, while high or repeated doses, or neonatal exposure, can disrupt myelin structure, impair oligodendrocyte viability, and produce cognitive, affective, and neurotoxic side effects. Myelin regulation may be a component of antidepressant action, but further research is needed to clarify mechanisms and implications for therapy.

DOI: 10.3389/fnins.2025.1690318 Full text Ketamine Neuroplasticity Neuronal activity-dependent myelination Oligodendrocytes +1