Glutamate NMDA Receptor Antagonists with Relevance to Schizophrenia: A Review of Zebrafish Behavioral Studies.
Current neuropharmacology March 4, 2022 Radharani Benvenutti, Matheus Gallas-Lopes, Matheus Marcon et al.
NMDAR antagonists like MK-801 and ketamine induce behavioral changes in zebrafish that model schizophrenia symptoms, including social interaction and memory deficits, but results for locomotor and exploratory behaviors are mixed. A review of 44 studies found that zebrafish are a suitable alternative to rodents for studying these drug-induced phenotypes, though more research is needed to understand species differences.