Increased inhibitory input to CA1 pyramidal cells alters hippocampal gamma frequency oscillations in the MK-801 model of acute psychosis.
Neurobiology of disease March 1, 2007 Colin Kehrer, Tamar Dugladze, Nino Maziashvili et al.
Exposure to the compound MK-801, which induces psychosis-like symptoms similar to those in acute schizophrenia, alters brain activity in an animal model. Gamma frequency oscillations in the hippocampus, evoked by kainate, were more powerful in animals that had received MK-801 than in controls. The resting membrane potential of pyramidal cells was more depolarized after MK-801, while other membrane properties remained unchanged. The authors suggest that changes in sodium-potassium pump activity and increased phasic inhibition may underlie these effects.