Journal of psychopharmacology (Oxford, England)
July 1, 2020
Emma J Mitchell, Ros R Brett, J Douglas Armstrong et al.
Automated homecage monitoring can detect changes in locomotion and social behavior caused by phencyclidine (PCP) in group-housed rats, offering a more naturalistic and less stressful alternative to conventional behavioral tests. Rats given PCP (2.5 mg/kg) traveled significantly greater distances from 15 to 60 minutes after injection and spent more time isolated from cage mates from 60 to 105 minutes after treatment. Unlike traditional assays that require moving animals to unfamiliar apparatus, in-cage monitoring captures the full time course of drug effects on multiple behaviors in the same animals, which may improve welfare and reproducibility in psychiatric drug research.
Psychopharmacology
February 1, 2011
David M Thomson, Allan McVie, Brian J Morris et al.
Cognitive problems in schizophrenia are not well treated by current drugs. The drug PCP is often used in animals to model these problems. In rats, a single dose of PCP increased impulsive, anticipatory responses 30 minutes after injection, but this effect disappeared within 24 hours. Repeated PCP treatment caused lasting delays in cognitive processing speed, which were partly improved by the antipsychotic clozapine. Clozapine also modified a measure of risk-taking versus caution (lnBeta) that was persistently altered by repeated PCP. The findings suggest that repeated PCP treatment combined with signal detection analysis provides a useful method for testing new cognitive enhancers.
Schizophrenia research
March 1, 2005
Lindsay M Reynolds, Susan M Cochran, Brian J Morris et al.
Repeated intermittent doses of phencyclidine (PCP) in rats caused deficits of N-acetylaspartate (NAA) and its precursor N-acetylaspartylglutamate (NAAG) specifically in the temporal cortex, while NAAG was elevated in the hippocampus. These changes mirror postmortem findings in schizophrenia, supporting the use of PCP-treated rats as a model for the neuronal dysfunction seen in that disease.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
February 1, 2003
Susan M Cochran, Matthew Kennedy, Clare E McKerchar et al.
Chronic intermittent exposure to phencyclidine (PCP) in rats produces metabolic hypofunction in the prefrontal cortex, reticular nucleus of the thalamus, and auditory system—key brain regions that show similar changes in schizophrenia. PCP also decreases parvalbumin mRNA expression in the prefrontal cortex and reticular nucleus of the thalamus. Co-administration of the antipsychotics haloperidol or clozapine did not reverse PCP-induced metabolic reductions in the prefrontal cortex but did reverse deficits in auditory structures. Clozapine, but not haloperidol, reversed PCP-induced decreases in parvalbumin expression in prefrontal cortex GABAergic interneurons, while both drugs reversed deficits in the reticular nucleus of the thalamus. These findings strengthen the validity of chronic PCP as an animal model of schizophrenia and suggest that reversing prefrontal cortex parvalbumin deficits may be a marker of atypical antipsychotic activity.