Behavioral effects of orally administered glycine in socially housed monkeys chronically treated with phencyclidine.
Psychopharmacology May 1, 2007 Gary S Linn, Robert T O'Keeffe, Kenneth Lifshitz et al.
Glycine treatment reversed the effects of the dissociative anesthetic PCP on stereotyped pacing in socially housed monkeys but had no effect on scanning behavior. Chronic PCP infusion in ten monkeys produced behavioral symptoms modeling both positive and negative symptoms of schizophrenia. Eight of ten animals experienced extreme motoric and physiological episodes during stressful events. The results suggest glycine may be beneficial for negative symptoms of schizophrenia, and that chronic PCP in primates could serve as a model for developing drugs targeting schizophrenia symptoms.