Effect of ketamine enantiomers and maternal deprivation on depressive-like behavior and plasma concentration of BDNF in rats
Research, Society and Development July 15, 2024 G. Beanes, Beatriz A. Carneiro, G. Marques et al.
In a study of male rats, maternal deprivation did not induce depressive-like behavior, and a single dose of ketamine, esketamine, or arketamine did not alter depressive-like behavior, anhedonic-like behavior, or locomotor activity. Plasma brain-derived neurotrophic factor levels also remained unchanged across all groups. The findings suggest that neither the maternal deprivation model nor the ketamine enantiomers produced measurable antidepressant-like effects in this experimental setup.