O RENASCIMENTO DOS PSICODÉLICOS E O TRATAMENTO DE DEPRESSÃO RESISTENTE
Asclepius International Journal of Scientific Health Science March 2, 2026 Laissa Guerreiro Santana Lucas, Sthéphany Karollyne Duarte Oliveira, Ravel Guerreiro Santana Lucas et al.
Treatment-resistant depression demands new approaches beyond conventional antidepressants. The revival of psychedelics, particularly psilocybin, offers a promising alternative based on modulating neuroplasticity. Studies indicate that single doses of psilocybin promote rapid reduction in MADRS and HAM-D scale scores. This effect arises from BDNF release, increased dendritic spine density, and temporary disintegration of the Default Mode Network, creating a plasticity window for psychotherapy. Psychedelics represent a paradigm shift, offering rapid remission through neurobiological restructuring. Future research should focus on durability of effects and standardization of clinical protocols.