Observational Determination of Dose-Response Curves in Hallucinogen-Treated Monkeys
International Pharmacopsychiatry August 11, 2017 J.M. Brewster, R.K. Siegel, C.A. Johnson et al.
Dimethyltryptamine (DMT) administered to adolescent rhesus monkeys in a dark environment produced dose-dependent increases in exploration, locomotion, stereotypy, spasm, tracking, and duration of inappropriate behavior. Some behaviors typically linked to specific stimuli, such as tracking and fear grimaces, appeared even without those stimuli in the dark, occurring more frequently than in a prior light-condition study. These results suggest hallucinogen-induced changes in perceptual-motor systems, possibly hallucinations.