Navigating Buprenorphine Therapy: A Closer Look at Microdosing vs. Macrodosing for Pain Management and Opioid Addiction - A Narrative Review.
Addiction & health October 1, 2024 Zachary I Merhavy, Marcos Flores, Eliu Rivera et al.
Buprenorphine therapy is a primary treatment for opioid addiction and chronic pain, but a one-size-fits-all approach is no longer adequate. This review compares two dosing strategies: microdosing, which uses minimal doses to reduce dependence and side effects, and macrodosing, which uses higher doses that are effective but raise concerns about misuse and overdose. Tailoring therapy to individual patient needs is essential for addressing contemporary healthcare challenges in pain management and opioid addiction.