Rational design, synthesis, and characterization of a solid Δ9-tetrahydrocannabinol (THC) nanoformulation suitable for “microdosing” applications
Abhinandan Banerjee, William Hosie, Ana Carolina Terso Ventura et al.
A THC-loaded nanoemulsion was created using an ethanol-assisted method without specialized equipment, producing lipid droplets averaging 190 nm. The nanoemulsion remained colloidally stable for at least six weeks, with no significant loss of cannabinoid potency. It withstood heat, freeze/thaw cycles, carbonation, dilution, high sucrose, and a pH range of 5-8. The nanoemulsion was converted into a water-soluble powder via lyophilization and ball-milling, suitable for microdosing applications. The powder was freely redispersible in water without phase separation, though it had limited free-flowing behavior.