Rapid modulation of spine morphology by the 5-HT 2A serotonin receptor through kalirin-7 signaling
Proceedings of the National Academy of Sciences November 4, 2009 Kelly A. Jones, Deepak P. Srivastava, John Allen et al. 215 citations
The 5-HT(2A) serotonin receptor, abundant in cortical pyramidal neurons and targeted by hallucinogens and psychiatric medications, is present in a subset of dendritic spines and colocalizes with PSD-95 and MUPP1. Activation by the agonist DOI transiently increases spine size and phosphorylates PAK, a downstream target of kalirin-7. Peptide interference preventing kalirin-7 localization to the postsynaptic density disrupts DOI-induced PAK phosphorylation and spine morphogenesis. These findings suggest serotonin signaling may modulate dendritic spine morphology through kalirin-7 at cortical synapses.